Characteristics of patients with hospital-acquired influenza A (H1N1)pdm09 virus admitted to the intensive care unit

Abstract

Influenza A (H1N1)pdm09 infection acquired in the hospital is an independent factor for death in critically ill patients admitted to the ICU.

Hospital-acquired influenza infections detected by a surveillance system over six seasons, from 2010/2011 to 2015/2016

“…While the mortality of nosocomial cases in the study by Enstone et. al was 26.7% [15], in the study by Álvarez-Lerma et al it was 39.2% [17]; in both studies mortality was notably higher than that due to community-acquired influenza [15,17]. Compared with community-acquired influenza cases, we found a significantly longer stay in patients with nosocomial influenza.…”

“…Even though vaccination rates were very low in patients with both hospital-acquired and communityacquired influenza virus infection, a higher proportion of nosocomial influenza patients had been vaccinated. This has been observed in other studies [15][16][17] and may be related to the greater number of comorbidities (COPD, diabetes, chronic renal disease, immunodeficiency and chronic cardiovascular disease) for which vaccination is recommended [18].…”

“…Our results are consistent with other studies that show sporadic nosocomial cases of influenza are a public health problem in acute-care hospital settings. Enstone [17]. Patients with hospital-acquired influenza infection had a profile that differed from that of patients with community-acquired infections; they were older, more likely to have chronic diseases (diabetes, chronic renal disease, immunodeficiency and chronic cardiovascular disease) and had higher mortality (18.8%).…”

Dynamic changes of lymphocyte counts in adult patients with severe pandemic H1N1 influenza A

“…Recent studies showed that9% of community-acquired pneumonia in Europe is associated with the infection of influenza viruses [2]. Moreover, influenza A (H1N1) pdm09 virus can cause hospital infection, resulting in death in critically ill patients admitted to the intensive care unit [3]. Influenza A/H1N1/pdm 2009 and influenza B viruses may co-infect patients during the epidemic season [4].…”

Implementation of influenza point-of-care testing and patient cohorting during a high-incidence season: a retrospective analysis of impact on infection prevention and control and clinical outcomes

“…The case fatality rate associated with influenza in hospitalised patients remains 3.4-8.3% [1] and may be twice as high when influenza is hospital-acquired (HAI) compared to communityacquired (CAI) [2]. Nosocomial influenza outbreaks lead to increased bed occupancy and closed wards during winter months, with significant financial implications.…”