Characteristics of patients with orofacial granulomatosis

McCartan, Bernard E.; Healy, Claire M.; McCreary, CE; Flint, SR; Rogers, S.; Toner, Mary

doi:10.1111/j.1601-0825.2011.01826.x

Cited by 65 publications

(76 citation statements)

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“…The identification of the triggering factors, though sometimes difficult, is of great importance in avoiding recurrences [3] . This association of OFG with food intake has been reported, and several substances have been mentioned [10,12] . Interestingly, in a recent study of 119 OFG cases, 30% of patients with OFG reported a possible association with food, mainly chocolate, carbonated drinks, and beer [10] .…”

Section: Discussionmentioning

confidence: 55%

“…OFG can encompass a broad of manifestations, including angular cheilitis, swelling of the cheek, full-thickness gingivitis, fissured tongue, mucosal ulcerations, linear oral ulceration, vertical fissures of the lips, and cobblestone or "basket of eggs" appearance of the buccal mucous membrane [7,9,10] . In this study, we provided a report of a case of OFG presenting as a recurrent swelling of the upper lip, mainly triggered by alcoholic beverages and soft drinks.…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of OFG is thought to be 0.8% [10] and it seems to have an equal prevalence in man and woman, in their 3rd…”

Section: Introductionmentioning

confidence: 99%

“…In addition, edema, dilated lymphatic and blood vessels, and perivascular lymphocytic infiltration are observed [2,10] . Of notice, the absence of granulomas does not exclude OFG diagnosis, and a non-specific inflammatory infiltrate may be the single finding [2,10] .…”

Section: Introductionmentioning

confidence: 99%

“…The etiopathogenesis of OFG is unknown, and genetics, allergy to food or dental materials, and infection have been mentioned as possible causes, and the immunological response seems to play an important role [3,9,10] . It is probable that food substances would evoke a delayed type hypersensitivity reaction, but it is to be clarified whether these antigenic irritants are causative or exacerbative agents [9,11,12] .…”

Section: Introductionmentioning

confidence: 99%

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Orofacial granulomatosis: insights from an immunohistochemical evaluation

Caldeira

Souto

Aguiar

et al. 2014

CRCP

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Objective: The aim of this paper was to report a case of orofacial granulomatosis, with immunohistochemical evaluation of some inflammatory cells that would be involved on its etiopathogenesis. Methods:The specimen was collected through biopsy for diagnostic proposal and was further submitted to immunohistochemistry for CD3, CD20, S-100, D2-40, and AE1/AE3. Immunohistochemical analysis was performed in inflammatory cells in granulomatous nodules and through the oral mucosa. Results:In the granulomas, CD3+ cells were the main component of inflammatory cells. S-100+ cells were seen diffusely distributed. CD20+ cells were observed in a lower amount than CD3+ and S-100+. D2-40 staining evidenced some large lymphatic vessels, which were surrounded by inflammatory cells. Besides the granulomas, an intense and diffuse inflammatory infiltrate was seen in connective tissue, immediately below the epithelium with a large number of CD3+ cells in intimate contact. A disorganization of the basal layer of epithelium was also present. AE1/AE3 was positive only in the keratinocytes. S-100+ cells were numerous in the connective tissue, and infiltrating the epithelium. CD20+ cells were observed in a lower number than CD3+ and S-100+, mainly located in a deeper region of the connective tissue.Conclusions: Dendritic cells and T lymphocytes were the major components of inflammatory infiltrate in oral mucosa and granulomatous nodules. The observed epithelial disorganization was quite similar to that of lichen planus. The findings corroborate to a cell-mediated immunological background of orofacial granulomatosis.

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