Characteristics of PDT performed very shortly after sensitizer injection

Abstract

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Comparing and combining light dose fractionation and iron chelation to enhance experimental photodynamic therapy with aminolevulinic acid

“…This simple concept has been described by several investigators and merely involves interrupting the light delivery part way through treatment. It has been successful when used with photosensitizers as diverse as HpD [22,23], AlS 4 Pc [24], and mTHPC [25,26] in a variety of normal and neoplastic tissues, but is most effective when used with ALA-induced PPIX [6,[27][28][29]. Using ALA in normal rat colon, a single 150-second dark interval after 20% of a light dose of 25 J had been delivered increased the area of necrosis by a factor of 3 [29].…”