Characteristics of pediatric invasive pneumococcal diseases and the pneumococcal isolates in Suzhou, China before introduction of PCV13

Zhang, Xiyan; Tian, Jianmei; Shan, Wei; Xue, Jian; Tao, Yunzhen; Geng, Qian; Ding, Yi-min; Zhang, Tao

doi:10.1016/j.vaccine.2017.06.046

Cited by 12 publications

(10 citation statements)

References 30 publications

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“… 4 , 18 , 19 Two recent studies showed that around 15%–16% of IPD children had an underlying disease. 12 , 20 In our identified IPD cases, underlying diseases were observed in 35 (28.45%) patients. Furthermore, concurrent infection with other pathogens was also reported in IPD children.…”

Section: Discussionmentioning

confidence: 72%

“…Most patients (98, 79.67%) were <5 years old and diagnosed during the cold season, which was similar to several recent reports from China. 12 , 17 For example, a recent study showed that most pediatric IPD patients (77 of 80) were aged <5 years. 12 Normally, IPD causes more severe clinical symptoms than noninvasive community-acquired pneumonia and can be fatal.…”

Section: Discussionmentioning

confidence: 99%

“… 12 , 17 For example, a recent study showed that most pediatric IPD patients (77 of 80) were aged <5 years. 12 Normally, IPD causes more severe clinical symptoms than noninvasive community-acquired pneumonia and can be fatal. Among these confirmed pediatric IPD cases, the overall mortality rate was 2.44% (three of 123), which was lower than other reports with mortality of 5.3%–27.5%.…”

Section: Discussionmentioning

confidence: 99%

“… 11 In addition, a total of 80 IPD children were identified from January 2010 to December 2015 in Suzhou. 12 In the current study, we aimed to analyze clinical features of pediatric IPD cases identified in Shanghai and Lanzhou, China and antimicrobial resistance of pneumococcal strains isolated from those IPD children.…”

Section: Introductionmentioning

confidence: 99%

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Clinical characteristics and antimicrobial resistance of pneumococcal isolates of pediatric invasive pneumococcal disease in China

Cai¹,

Wang²,

Xü³

et al. 2018

IDR

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PurposeStreptococcus pneumoniae causes serious infections globally, including invasive pneumococcal disease (IPD). We analyze clinical features of pediatric IPD cases identified in China and antibiotic susceptibility of isolated pneumococcal strains.MethodsConfirmed pediatric IPD patients were prospectively recruited to the study. Symptoms at the time of hospitalization, laboratory tests, antimicrobial susceptibility of pneumococcal isolates, treatments, hospital stay, and residual findings at discharge were analyzed systematically.ResultsFrom January 2008 to December 2017, a total of 123 hospitalized children diagnosed with IPD were enrolled: 68 from pediatric departments of Xinhua Hospital, and 55 from Lanzhou University Second Hospital. Of these pediatric IPD patients, 81 (65.86%) were male, and 98 (79.67%) <5 years old. Most cases (96, 78.05%) were diagnosed during the cold season between September and February. Sepsis was observed in 82 (66.67%) patients, 48 (39.02%) children were diagnosed with meningitis, 41 (33.33%) with pneumonia, 30 (24.39%) with pleurisy, and 4 (3.25%) with osteomyelitis. Underlying diseases were noted in 35 (28.45%) patients and concurrent infections in 45 (36.58%). The overall mortality rate was 2.44%. IPD children who developed sepsis and necrotizing pneumonia showed higher proportions of intensive care-unit admission, intravenous γ-globulin, glucocorticoid use, hemofiltration and ventilator, and longer duration of fever, hospital stay, and antibiotic use than nonsepsis and pneumonia subjects. Antimicrobial resistance of S. pneumoniae showed a highly unsusceptible rate for erythromycin (96.75%), trimethoprim-sulfamethoxazole (79.67%), and tetracycline (77.23%). All isolates were sensitive to vancomycin, linezolid, and levofloxacin.ConclusionClinical symptoms were severe in the majority of pediatric IPD patients. More intensive treatments were demanded for IPD children with sepsis and necrotizing pneumonia. High resistance rates for erythromycin, trimethoprim–sulfamethoxazole, and tetracycline were found.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical characteristics and antimicrobial resistance of pneumococcal isolates of pediatric invasive pneumococcal disease in China

Cai¹,

Wang²,

Xü³

et al. 2018

IDR

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“…Various standardized phenotypic antimicrobial susceptibility testing methods such as agar diffusion [11], broth microdilution [12], gradient strip tests [13], and disk diffusion [14] have traditionally been used by researchers to determine whether the bacteria are resistant or susceptible. Resistance to specific antibiotics can also be determined by PCR, which investigates the presence or absence of genes responsible for the resistance [15].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Susceptibility Test for the Determination of Resistant and Susceptible S. aureus and Enterococcus spp. Using a Multi-Channel Surface Plasmon Resonance Device

Ozkaya

Durak²,

Akyar³

et al. 2019

Diagnostics

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The objective of this study was to investigate the development of a surface plasmon resonance (SPR) sensor platform equipped with multiple channels for the simultaneous determination of methicillin-resistant S. aureus (MRSA), methicillin-susceptible S. aureus (MSSA) and vancomycin-resistant Enterococcus (VRE), and vancomycin-susceptible Enterococcus (VSE). Drug resistance of S. aureus strains against cefoxitin and Enterococcus strains against vancomycin were investigated both using the minimum inhibitory concentration method (MIC) assay and the SPR system equipped with single and multiple channels. The MIC values of MRSA and MSSA ranged from 32 µg/mL to >128 µg/mL and from 1 µg/mL to 4 µg/mL, respectively. The MIC values of VRE and VSE were between 64 to >128 µg/mL and 2–4 µg/mL, respectively. With the multiple-channel system, the angle shifts of MRSA, MSSA, VRE and VSE were found to be −0.030° and −0.260°, −0.010° and −0.090° respectively. The antibiotic-resistant and susceptible strains were distinguished within 3 h for S. aureus strains and within 6 h for Enterococcus strains.

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Antimicrobial susceptibility profiles of invasive bacterial infections among children from low- and middle-income countries in the Western Pacific Region (WPRO) – a systematic review and meta-analysis

Moore,

Ashley,

Dickson

et al. 2024

The Lancet Regional Health - Western Pacific

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Characteristics of pediatric invasive pneumococcal diseases and the pneumococcal isolates in Suzhou, China before introduction of PCV13

Cited by 12 publications

References 30 publications

Clinical characteristics and antimicrobial resistance of pneumococcal isolates of pediatric invasive pneumococcal disease in China

Clinical characteristics and antimicrobial resistance of pneumococcal isolates of pediatric invasive pneumococcal disease in China

Antimicrobial Susceptibility Test for the Determination of Resistant and Susceptible S. aureus and Enterococcus spp. Using a Multi-Channel Surface Plasmon Resonance Device

Antimicrobial susceptibility profiles of invasive bacterial infections among children from low- and middle-income countries in the Western Pacific Region (WPRO) – a systematic review and meta-analysis

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