Characteristics of Pediatric Recurrent Bacterial Meningitis in Beijing Children’s Hospital, 2006–2019

Chen, Tian-Ming; Chen, Heying; Hu, Bing; Hu, Huili; Guo, Xin; Guo, Lingyun; Li, Shaoying; Liu, Gang

doi:10.1093/jpids/piaa176

Cited by 7 publications

(14 citation statements)

References 21 publications

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“…Among the most important causes of meningitis recurrence in this study: peritoneal cerebral shunt in 42.9% of them, skull fracture in 40% of them, and meningocele in 25% of them. Compared to a study conducted in China, the recurrence rate for those with a skull fracture was 20%, and for those with meningocele, it was 11% (12). The high rates in this study may explain the di culty in managing some of the previous predisposing lesions.…”

Section: Discussioncontrasting

confidence: 64%

investigation on the prevalence of complication of bacterial meningitis and its related factors in children after the neonatal period- a retrospective study.

Almohamed

Khazem

2023

Preprint

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Background: Bacterial meningitis in children is a life-threatening condition, carrying a potentially large proportion of morbidity and mortality. Early reorganization of accurate diagnosis, and correct management are important in regard to avoiding complications and death. Others, such as the type of pathogen, also play an important role. Methods: This retrospective cross-sectional study was conducted after obtaining ethical approval from the IRB, Faculty of Medicine, Syrian Private University. The study included a review of all cases of bacterial meningitis among children attending Damascus Hospital, during the period between the beginning of 2017 and the end of 2022. Results: The number of cases of bacterial meningitis reached 122 patients, 56% of the sample were males, and infants were the most common age group. Crowded housing was found in 73% of patients. The percentage of positive bacterial cultures for CSF was 24.6% of the sample, while the percentage of positive cultures for Haemophilus influenzae, Streptococcus pneumoniae, and Neisseria meningitidis was few. The incidence of complications was 32% of the sample, where the duration of the fever for more than 10 days was the most common complication, followed by organ failure accompanying trauma, inappropriate ADH secretion syndrome, and intracranial hypertension, respectively. Complications occurred more among females than males, and were also higher among infants than the rest of the age groups, and also higher among those with overcrowded housing.The occurrence of complication was statistically associated with hospital acquisition, hospitalization period, and bacterial type. The death rate was 4% of the sample, 60% of whom were females. In 80% of the deceased, diagnosis and treatment were delayed for a week, and 80% of them were adult children. It was found statistically that the longer the hospitalization period is associated with a higher risk of death. Conclusion:This study indicates the occurrence of both complications and death in pediatric patients with bacterial meningitis in Damascus Hospital. The disease itself carries a high risk of both morbidity and mortality, but the results of this study identify some factors whose correct control may avoid their occurrence as well as avoid long-term sequela.

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Section: Discussioncontrasting

confidence: 64%

investigation on the prevalence of complication of bacterial meningitis and its related factors in children after the neonatal period- a retrospective study.

Almohamed

Khazem

2023

Preprint

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“…In 2019, a multicenter study of children with recurrent pneumococcal meningitis showed an incidence of 1.5% [ 4 ]. A recent study showed that RBM incidence in children in Beijing, China, was 2.3%, which is relatively uncommon [ 5 ]. This study analyzed the clinical manifestations, auxiliary examination, and therapeutic outcomes of 10 Chinese children with RBM admitted to Hebei Children's Hospital from 2012 to 2020.…”

Section: Introductionmentioning

confidence: 99%

A Retrospective Study of Recurrent Bacterial Meningitis in Children: Etiology, Clinical Course, and Treatment

Liu

Pang

et al. 2022

Computational and Mathematical Methods in Medicine

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Objectives. Recurrent bacterial meningitis (RBM) is a rare but life-threatening disease. This study aims to analyze the clinical features, potential causes, and therapeutic outcomes of RBM in children. Methods. This article retrospectively reviews the clinical characteristics, etiologies, and treatments in children with RBM hospitalized in Hebei children’s hospital from 2012 to 2020. Results. A total of 10 children with RBM, five males and five females, were included in this study. The age of RBM in children spans from the neonatal stage to the childhood stage. The underlying illnesses were identified and classified as cerebrospinal fluid rhinorrhea (1 case), humoral immunodeficiency with Mondini dysplasia (1 case), common cavity deformity with cerebrospinal fluid ear leakage (1 case), Mondini malformations (2 cases), incomplete cochlear separation type I with a vestibular enlargement (2 cases), local inflammation of the sphenoid bone caused by cellulitis (1 case), congenital skull base defects (1 case), and congenital dermal sinus with intraspinal abscess (1 case). 6 patients chose targeted therapy for potential reasons. Conclusions. Congenital abnormalities or acquired injuries lead to intracranial communication with the outside world, which can quickly become a portal for bacterial invasion of the central nervous system, resulting in repeated infections.

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“…Currently, there is no consensus on when immunological investigations should be initiated in children with IPD. The decision on whether to do an immune evaluation in children with IPD is often based on a child’s age at presentation, the site of infection (with meningitis considered the highest risk 29 ), recurrent IPD 21,30,31 and the presence of ≥2 warning signs of IEI. 22,32 Some studies suggest that certain age groups have a greater likelihood of having an underlying IEI.…”

Section: Discussionmentioning

confidence: 99%

Inborn Errors of Immunity in Children With Invasive Pneumococcal Disease: A Multicenter Prospective Study

Phuong

Cheung

Agrawal

et al. 2023

Pediatric Infectious Disease Journal

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Background: In settings with universal conjugate pneumococcal vaccination, invasive pneumococcal disease (IPD) can be a marker of an underlying inborn error of immunity. The aim of this study was to determine the prevalence and characterize the types of immunodeficiencies in children presenting with IPD. Methods: Multicenter prospective audit following the introduction of routinely recommended immunological screening in children presenting with IPD. The minimum immunological evaluation comprised a full blood examination and film, serum immunoglobulins (IgG, IgA and IgM), complement levels and function. Included participants were children in whom Streptococcus pneumoniae was isolated from a normally sterile site (cerebrospinal fluid, pleura, peritoneum and synovium). If isolated from blood, features of sepsis needed to be present. Children with predisposing factors for IPD (nephrotic syndrome, anatomical defect or malignancy) were excluded. Results: Overall, there were 379 episodes of IPD of which 313 (83%) were eligible for inclusion and 143/313 (46%) had an immunologic evaluation. Of these, 17/143 (12%) were diagnosed with a clinically significant abnormality: hypogammaglobulinemia (n = 4), IgA deficiency (n = 3), common variable immunodeficiency (n = 2), asplenia (n = 2), specific antibody deficiency (n = 2), incontinentia pigmenti with immunologic dysfunction (n = 1), alternative complement deficiency (n = 1), complement factor H deficiency (n = 1) and congenital disorder of glycosylation (n = 1). The number needed to investigate to identify 1 child presenting with IPD with an immunologic abnormality was 7 for children aged under 2 years and 9 for those 2 years and over. Conclusions: This study supports the routine immune evaluation of children presenting with IPD of any age, with consideration of referral to a pediatric immunologist.

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Characteristics of Pediatric Recurrent Bacterial Meningitis in Beijing Children’s Hospital, 2006–2019

Cited by 7 publications

References 21 publications

investigation on the prevalence of complication of bacterial meningitis and its related factors in children after the neonatal period- a retrospective study.

investigation on the prevalence of complication of bacterial meningitis and its related factors in children after the neonatal period- a retrospective study.

A Retrospective Study of Recurrent Bacterial Meningitis in Children: Etiology, Clinical Course, and Treatment

Inborn Errors of Immunity in Children With Invasive Pneumococcal Disease: A Multicenter Prospective Study

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