Characteristics of Potential Living Kidney Donors and Recipients: Donor Disqualification Reasons—Experience of a Polish Center

Gozdowska, Jolanta; Jankowski, Krzysztof; Bieniasz, M.; Wszoła, Michał; Domagała, Piotr; Kieszek, R.; Lewandowska, Dorota; Urbanowicz, A.; Szmidt, J; Grenda, Ryszard; Kwiatkowski, A.; Chmura, A.; Durlik, M.

doi:10.1016/j.transproceed.2013.01.030

Cited by 9 publications

(8 citation statements)

References 9 publications

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“…Two UK single-centre cohort studies have reported the proportion of potential donors that actually go on to donate as 13% 3 and 18%. 4 Studies from the Republic of Ireland, 5 the Netherlands, 6 Poland, 7 South Africa, 8 and the USA, [9][10][11] have reported varied estimates of between 8-49% of potential donors becoming actual donors. Almost all of these studies were single-centre and the predictors of donation and of non-donation have not been well described.…”

Section: Introductionmentioning

confidence: 99%

A multicenter cohort study of potential living kidney donors provides predictors of living kidney donation and non-donation

Bailey

Tomson

MacNeill

et al. 2017

Kidney International

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This multicenter prospective potential living kidney donor cohort study investigated which sociodemographic and other factors predict progression to living kidney donation or donor withdrawal as little is known on this topic. Therefore, we examined data on individuals undergoing living donor assessment at seven hospitals in the United Kingdom. Multivariable logistic regression was used to explore the relationships between donor and recipient characteristics and likelihood of kidney donation. A total of 805 individuals presented for directed donation to 498 intended recipients, of which 112 received a transplant from a living donor. Potential donors were less likely to donate if their intended recipient was female rather than male with an odds ratio of 0.60, a friend rather than relative 0.18, or had renal failure due to a systemic disease rather than another cause 0.41. The most socioeconomically deprived quintile was less likely to donate than the least 0.49, but the trend with deprivation was consistent with chance. Higher body mass index was associated with a lower likelihood of donation (odds ratio per each kg/m increase, 0.92). Younger potential donors (odds ratio per each year increase 0.97), those of nonwhite ethnicity 2.98, and friend donors 2.43 were more likely to withdraw from work-up. This is the first study in the United Kingdom of potential living kidney donors to describe predictors of non-donation. Qualitative work with individuals who withdraw might identify possible ways of supporting those who wish to donate but experience difficulties doing so.

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Section: Introductionmentioning

confidence: 99%

A multicenter cohort study of potential living kidney donors provides predictors of living kidney donation and non-donation

Bailey

Tomson

MacNeill

et al. 2017

Kidney International

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“…Current guidelines for LKD evaluation providing recommendations for the transplant community show some differences in acceptable thresholds for living donors, which, among other factors, explain the variability of donor acceptance in transplant programs worldwide (7)(8)(9)(10)(11). These differences are evidenced by several studies reporting on the proportion and the reasons for exclusion of prospective living donors (12)(13)(14). However, data on why potential donors are disqualified for LKD in Germany are lacking.…”

Section: Introductionmentioning

confidence: 99%

Disqualification of Donor and Recipient Candidates From the Living Kidney Donation Program: Experience of a Single-Center in Germany

et al. 2022

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BackgroundKidney transplantation is the best treatment option for patients with end-stage kidney disease (ESKD) with a superiority of graft survival after living kidney donation (LKD) compared to deceased donation. However, a large part of potential donors and recipients are ineligible for LKD. Here, we analyze the leading causes for disqualification of potential living donor-recipient pairs from the LKD program and the health-related consequences for ESKD patients excluded from the LKD program in a German transplant center.MethodsIn this single-center retrospective cohort study we evaluated all candidates (potential donors and recipients) presenting for assessment of LKD from 2012 to 2020 at our transplant center. Thereby we focused on candidates excluded from the LKD program. Main reasons for disqualification were categorized as medical (donor-related), psychosocial, immunological, recipient-related, and unknown.ResultsOverall, 601 donor-recipient pairs were referred to our transplant center for LKD assessment during the observation time. Out of those, 326 (54.2%) discontinued the program with 52 (8.7%) dropouts and 274 (45.6%) donor-recipient pairs being ineligible for LKD. Donor-related medical contraindications were the main reason for disqualification [139 out of 274 (50.7%) potential donors] followed by recipient-related contraindications [60 out of 274 (21.9%) of potential donor-recipient pairs]. Only 77 out of 257 (29.9%) potential recipients excluded from the LKD program received a kidney transplant afterward with a median waiting time of 2 (IQR: 1.0–4.0) years. Overall, 18 (7.0%) ESKD patients initially declined for LKD died in this period.ConclusionA large percentage of donor-recipient pairs are disqualified from the German LKD program, mostly due to medical reasons related to the donor and with partly severe consequences for the potential recipients. For these, alternative solutions that promptly enable kidney transplantation are essential for improving patient quality of life and survival.

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“…Of these, diabetes or impaired glucose tolerance were the most frequent followed by obesity and hypertension. Similarly, other local and global studies showed that the most common reasons for the rejection of potential LKDs were medical with diabetes and hypertension constituting the majority of the medical reasons [10,11,17]. At our center, we decline all potential LKDs with diabetes or impaired glucose tolerance based on fasting blood glucose and HbA1c.…”

Section: Discussionmentioning

confidence: 72%

Why Living Kidney Donor Candidates Are Turned Down? A Single-Center Cohort Study

Altheaby

Almukhlifi

Aldoukhi

et al. 2020

Cureus

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Characteristics of Potential Living Kidney Donors and Recipients: Donor Disqualification Reasons—Experience of a Polish Center

Cited by 9 publications

References 9 publications

A multicenter cohort study of potential living kidney donors provides predictors of living kidney donation and non-donation

A multicenter cohort study of potential living kidney donors provides predictors of living kidney donation and non-donation

Disqualification of Donor and Recipient Candidates From the Living Kidney Donation Program: Experience of a Single-Center in Germany

Why Living Kidney Donor Candidates Are Turned Down? A Single-Center Cohort Study

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