Characteristics of primary glomerular diseases patients with hematuria in Turkey: the data from TSN-GOLD Working Group

Şumnu, Abdullah; Türkmen, Kültiğin; Cebeci, Egemen; Türkmen, Aydın; Eren, Necmi; Seyahi, Nurhan; Oruç, Ayşegül; Dede, Fatih; Derici, Ülver; Baştürk, Taner; Şahin, Garip; Sipahioğlu, Murat Hayri; Şahin, Gülizar Manga; Tatar, Erhan; Dursun, Belda; Sipahi, Savaş; Yılmaz, Mürvet; Süleymanlar, Gültekin; Ulu, Sena; Güngör, Özkan; Kutlay, Sim; Bahçebaşı, Zerrin Bicik; Şahi̇n, İdris; Kurultak, İlhan; Sevinç, Can; Yilmaz, Zulfikar; Kazancıoğlu, Rümeyza; Çavdar, Caner; Candan, Ferhan; Aydın, Zeki; Oygar, Deren; Gül, Bülent; Altun, Bülent; Paydaş, Saime; Uzun, Sami; Istemihan, Zulal; Ergül, Metin; Dinçer, Mevlüt Tamer; Güllülü, Mustafa; Piskinpasa, Serhan; Akcay, Omer Faruk; Ünsal, Abdülkadir; Koyuncu, Sümeyra; Gök, Mahmut; Öztürk, Savaş

doi:10.1007/s11255-020-02690-w

Cited by 3 publications

(4 citation statements)

References 18 publications

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“…Forty-seven nephrology units throughout Turkey have been providing data for the registry, including kidney-biopsy proven glomerular diseases. Previously, several studies have been conducted with the data obtained from this registry [ 8 , 10 , 11 ]. The total number of patients in the registry at the time of the evaluation was 4399.…”

Section: Methodsmentioning

confidence: 99%

Clinical and pathologic features of primary membranous nephropathy in Turkey: a multicenter study by the Turkish Society of Nephrology Glomerular Diseases Working Group

et al. 2022

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Background We aimed to evaluate the features of primary membranous nephropathy (MNP) in Turkish people. Methods This is a retrospective analysis of patients with biopsy-proven primary MNP. We obtained the data collected between 2009 and 2019 in the primary glomerulonephritis registry of the Turkish Society of Nephrology Glomerular Diseases Study Group (TSN-GOLD). Patients with a secondary cause for MNP were excluded. Clinical, demographic, laboratory, and histopathological findings were analyzed. Results A total of 995 patients with primary MNP were included in the analyses. Males constituted the majority (58.8%). The mean age was 48.4 ± 13.9 years. The most common presentation was the presence of nephrotic syndrome (81.7%) and sub nephrotic proteinuria (10.3%). Microscopic hematuria was detected in one-third of patients. The median estimated glomerular filtration rate (eGFR) was 100.6 mL/min/1.73 m 2 (IQR, 75.4–116.3), and median proteinuria was 6000 mg/d (IQR, 3656–9457). Serum C3 and C4 complement levels were decreased in 3.7 and 1.7% of patients, respectively. Twenty-four (2.4%) patients had glomerular crescents in their kidney biopsy samples. Basal membrane thickening was detected in 93.8% of cases under light microscopy. Mesangial proliferation and interstitial inflammation were evident in 32.8 and 55.9% of the patients, respectively. The most commonly detected depositions were IgG (93%), C3 complement (68.8%), and kappa and lambda immunoglobulin light chains (70%). Although renal functions were normal at presentation, vascular, interstitial, and glomerular findings were more prominent on biopsy in hypertensive patients. No significant effect of BMI on biopsy findings was observed. Conclusions Despite some atypical findings, the main features of primary MNP in Turkey were similar to the published literature. This is the largest MNP study to date conducted in Turkish people.

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Section: Methodsmentioning

confidence: 99%

Clinical and pathologic features of primary membranous nephropathy in Turkey: a multicenter study by the Turkish Society of Nephrology Glomerular Diseases Working Group

et al. 2022

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“…Demographic parameters and chronic diseases before renal biopsy (hypertension, tuberculosis, diabetes mellitus, and cardiac disease), indication for renal biopsy, the date of biopsy, the clinic at which the biopsy was performed, clinical diagnosis, pathological diagnosis, the medications that the patients were taking before renal biopsy and detailed description of pathological findings were recorded for all patients to the database [18,19].…”

Section: Patient Characteristics and Definitionsmentioning

confidence: 99%

“…The patients' data collected include age, gender, body mass index (BMI), blood pressure, and laboratory parameters including hemogram, lipid profile, renal function tests, albumin, total protein, 24-h proteinuria, glucose, uric acid, calcium, alanine aminotransferase (ALT), erythrocyte sedimentation rate (ESR) and light microscopic findings including tubular atrophy, interstitial fibrosis, number of total glomeruli, number of crescentic glomeruli, and number of sclerotic glomeruli, immunofluorescence findings such as immunoglobulin (Ig)G, IgA, IgM, kappa, lambda, fibrinogen, C3 and C1q, serology for human immunodeficiency virus and hepatitis C virus and hepatitis B surface antigen, and an autoimmune panel including complement levels (C3 and C4 levels), anti-nuclear antibody (ANA), anti-doublestranded DNA antibody (anti-dsDNA Ab), ANCA [as antimyeloperoxidase (anti-MPO) and anti-proteinase 3 (anti-PR3)], and anti-GBM antibody. No limitation was applied to the methods of laboratory investigations, and all parameters were measured with the locally available techniques [18,19].…”

Section: Patient Characteristics and Definitionsmentioning

confidence: 99%

“…RPGN was defined as an acute/subacute decrease in renal functions within hours or days associated with proteinuria, microscopic hematuria, and positive autoantibodies. "Active urinary sediment" was defined by the presence of dysmorphic red blood cells (40% of the erythrocytes) or erythrocyte casts (one or more red blood cell casts/HPF) or hematuria (presence of at least five red blood cells/HPF) in urine microscopy [18,19].…”

Section: Patient Characteristics and Definitionsmentioning

confidence: 99%

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Trends of primary glomerular disease in Turkey: TSN-GOLD registry report

et al. 2022

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Background Although several renal biopsy registry reports have been published worldwide, there are no data on primary glomerular disease trends in Turkey. Methods Three thousand eight-hundred fifty-eight native kidney biopsy records were assessed in the Turkish Society of Nephrology Primary Glomerulopathy Working Group (TSN-GOLD) Registry. Secondary disease and transplant biopsies were not recorded in the registry. These records were divided into four periods, before 2009, 2009 to 2013, 2013-2017, and 2017-current. Results A total of 3858 patients (43.6% female, 6.8% elderly) were examined. Nephrotic syndrome was the most common biopsy indication in all periods (58.6%, 53%, 44.1%, 51.6%, respectively). In the whole cohort, IgA nephropathy (IgAN) (25.7%) was the most common PGN with male predominance (62.7%), and IgAN frequency steadily increased through the periods (× 2 = 198, p < 0.001). MGN was the most common nephropathy in the elderly (> 65 years), and there was no trend in this age group. An increasing trend was seen in the frequency of overweight patients (× 2 = 37, p < 0.0001). Although the biopsy rate performed with interventional radiology gradually increased, the mean glomeruli count in the samples did not change over the periods. Conclusions In Turkey, IgAN is the most common primary glomerulonephritis, and the frequency of this is increasing.

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Demographic and Clinical Features and Factors Associated with Survival in Patients with Primary Glomerulonephritis: Single Tertiary Center Experience

Paksoy¹,

Trabulus²,

Seyahi³

et al. 2023

NKTD

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Characteristics of primary glomerular diseases patients with hematuria in Turkey: the data from TSN-GOLD Working Group

Cited by 3 publications

References 18 publications

Clinical and pathologic features of primary membranous nephropathy in Turkey: a multicenter study by the Turkish Society of Nephrology Glomerular Diseases Working Group

Clinical and pathologic features of primary membranous nephropathy in Turkey: a multicenter study by the Turkish Society of Nephrology Glomerular Diseases Working Group

Trends of primary glomerular disease in Turkey: TSN-GOLD registry report

Demographic and Clinical Features and Factors Associated with Survival in Patients with Primary Glomerulonephritis: Single Tertiary Center Experience

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