Characteristics of puumala and Dobrava infections in Croatia*

Markotić, Alemka; St, Nichol; Kuzman, Ilija; Aj, Sanchez; Tg, Ksiazek; Gagro, Alenka; Rabatić, Sabina; Zgorelec, Renata; Avšič–Županc, Tatjana; Beus, I; Dekaris, Dragan

doi:10.1002/jmv.2179

Cited by 70 publications

(78 citation statements)

References 23 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, DOBV seropositive patients in our study had more severe renal impairment compared with the PUUV and non-id hantavirus positive patients as witnessed by the diuresis, serum urea and creatinine values during the acute stage of the illness. Our results are in line with previous reports from B&H, Croatia and Slovenia that associated DOBV with severe form of HFRS (13,14,15,16,17).…”

Section: Discussionsupporting

confidence: 94%

“…DOBV patients in our study had significantly lower diuresis values compared to PUUV which can be explained with the larger study sample of the patients included in this study. Reports from Croatia also associated DOBV infection with a more severe disease than PUUV infection, but also confirmed previous findings that even PUUV infection could lead to a severe disease (13,14,17). Markotic et al (17) observed that a significantly higher proportion of DOBV-infected patients had acute renal failure, visual disturbance, severe thrombocytopenia, and elevated levels of nonsegmented leukocytes, creatine, and total bilirubin.…”

Section: Discussionsupporting

confidence: 72%

“…Reports from Croatia and Slovenia where PUUV and DOBV also coexist suggested that DOBV-infected patients exhibited significant differences in illness severity (13,14,15,16). DOBV infected patients suffered more frequently from acute renal failure requiring dialysis treatment, shock, visual disturbances, and severe thrombocytopenia, hemorrhagic complications and disseminated intravascular coagulation than in patients with PUUV infection (17).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pathogenicity and virulence of the present hantaviruses in Bosnia and Herzegovina: the impact on renal function

Hukić

Valjevac

Tulumović

et al. 2010

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

SummaryDobrava (DOBV) and Puumala (PUUV) viruses are endemic throughout the Balkans and cause high fever with renal syndrome (HFRS). The aim was to assess impact of two different HTV on renal function in HFRS patients during acute stage of illness. We also aimed to assess DOBV and PUUV distribution between symptomatic, HFRS patients and asymptomatic hantavirus antibody positive subjects. The study included 264 symptomatic, HFRS patients and 63 asymptomatic hantavirus antibody positive healthy subjects. In our study, 131 (49,6%) HFRS patients were regarded as PUUV and 69 (26,1%) as DOBV-infected patients, while in 64 (24,2%) of HFRS patients that showed all clinical and biochemical signs of HFRS, the causal hantavirus could not be determined with commercially available tests. DOBV-infected patients were associated with more requirements for haemodialysis treatment, lower diuresis and higher serum creatinine and urea values compared to PUUV-infected patients. PUUV was significantly predominant in asymptomatic hantavirus antibody positive subjects (69,8%) compared to HFRS patients. DOBV was present in 17,5% of asymptomatic subjects and interestingly, the preferential hantavirus serotype could not be determined in 12,7% of the asymptomatic antibody-positive subjects.

show abstract

Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 72%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pathogenicity and virulence of the present hantaviruses in Bosnia and Herzegovina: the impact on renal function

Hukić

Valjevac

Tulumović

et al. 2010

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

show abstract

“…During the 2002 Croatian outbreak, 401 cases of HFRS were recorded. Except for the coastal region and islands, the whole country was found to be an area endemic for HFRS [11][12][13]. In 2012, 154 patients were described, of whom 69.5% acquired the infection on the Medvednica mountain near the Croatian capital of Zagreb [14].…”

Section: Introductionmentioning

confidence: 99%

Clinical and virological characteristics of hantavirus infections in a 2014 Croatian outbreak

Vilibić-Čavlek

Furic²,

Barbić

et al. 2017

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: Croatia is endemic for hemorrhagic fever with renal syndrome (HFRS), with both Puumala (PUUV) and Dobrava virus (DOBV) documented. Several large outbreaks were recorded in 1995, 2002, and 2012. We analyzed demographic, clinical, laboratory, and virological characteristics of HFRS cases detected in three geographically close natural foci (Ogulin, Slunj, and the Plitvice Lakes surroundings) during the 2014 outbreak. Methodology: From January to December 2014, 122 patients with suspected HFRS were tested for hantavirus IgM/IgG antibodies using an indirect immunofluorescence assay (IFA). Cross-reactive samples were further tested using a western blot (WB). For hospitalized patients from Ogulin area, clinical and laboratory data were analyzed. Results: Acute infection was documented in 57 (46.7%) patients, of whom 75.4% were hospitalized. Ten (8.2%) patients were found to be IgG seropositive. Patients were 15-69 years of age and predominantly male (74.5%). The outbreak started in winter months, with most cases recorded from May to July (80.7%). The most frequently reported symptoms were fever (96.3%), chills/shivering (62.9%), and lumbar pain (48.1%). Mild clinical form was found in 66.7% patients, moderate in 18.5%, and severe in 14.8% patients (all but one infected with PUUV). One patient died. Using IFA, 48.8% patients showed monotypic antibody response, while in 51.2%, cross-reactive antibodies were found. PUUV was confirmed in 94.7% and DOBV in 5.3% HFRS cases by WB. Conclusions: Central mountainous Croatian regions are still highly endemic areas for HFRS. A higher percentage of severe PUUV infections could be at least partly associated with a patient's immune status.

show abstract

“…These include Dobrava (DOBV) and Puumala (PUUV) viruses, implicated in hemorrhagic fever with renal syndrome, and the nonpathogenic Tula (TULV) and Saaremaa viruses. [10][11][12][13][14] Rodents can also be infected with flaviviruses, orthopoxviruses, and lymphocytic choriomeningitis virus (LCMV); however, to our knowledge, there are no published reports of investigation for the presence of these viruses in Croatia. [15][16][17] Rodents in Croatia are also reservoirs of protozoan Apicomplexa parasites, including Toxoplasma and Babesia that cause toxoplasmosis and babesiosis, respectively, mainly in immunocompromised individuals.…”

Section: Introductionmentioning

confidence: 99%

Molecular Survey of Zoonotic Agents in Rodents and Other Small Mammals in Croatia

Tadin¹,

Tokarz²,

Markotić³

et al. 2016

The American Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract. Croatia is a focus for many rodent-borne zoonosis. Here, we report a survey of 242 rodents and small mammals, including 43 Myodes glareolus, 131 Apodemus flavicollis, 53 Apodemus agrarius, three Apodemus sylvaticus, six Sorex araneus, four Microtus arvalis, one Microtus agrestis, and one Muscardinus avellanarius, collected at eight sites in Croatia over an 8-year period. Multiplex MassTag polymerase chain reaction (PCR) was used for detection of Borrelia, Rickettsia, Bartonella, Babesia, Ehrlichia, Anaplasma, Francisella tularensis, and Coxiella burnetii. Individual PCR assays were used for detection of Leptospira, lymphocytic choriomeningitis virus, orthopoxviruses, flaviviruses, hantaviruses, and Toxoplasma gondii. Of the rodents, 52 (21.5%) were infected with Leptospira, 9 (3.7%) with Borrelia miyamotoi, 5 (2%) with Borrelia afzelii, 29 (12.0%) with Bartonella, 8 (3.3%) with Babesia microti, 2 (0.8%) with Ehrlichia, 4 (1.7%) with Anaplasma, 2 (0.8%) with F. tularensis, 43 (17.8%) with hantaviruses, and 1 (0.4%) with an orthopoxvirus. Other agents were not detected. Multiple infections were found in 32 rodents (13.2%): dual infections in 26 rodents (10.7%), triple infections in four rodents (2.9%), and quadruple infections in two rodents (0.8%). Our findings indicate that rodents in Croatia harbor a wide range of bacteria and viruses that are pathogenic to humans.

show abstract

Characteristics of puumala and Dobrava infections in Croatia*

Cited by 70 publications

References 23 publications

Pathogenicity and virulence of the present hantaviruses in Bosnia and Herzegovina: the impact on renal function

Pathogenicity and virulence of the present hantaviruses in Bosnia and Herzegovina: the impact on renal function

Clinical and virological characteristics of hantavirus infections in a 2014 Croatian outbreak

Molecular Survey of Zoonotic Agents in Rodents and Other Small Mammals in Croatia

Contact Info

Product

Resources

About