Characteristics of radiation-induced sensorineural hearing loss in head and neck cancer: A systematic review

Mujica‐Mota, Mario A.; Waissbluth, Sofia; Daniel, Sam J.

doi:10.1002/hed.23201

Cited by 61 publications

(73 citation statements)

References 34 publications

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“…Investigators described that platinnun drugs affected 14% of cancer treatment´s survivors once these drugs are considered not only ototoxic, but neurotoxic [15]. The incidence of hearing loss for head and neck cancer, in our study was 28.8% therefore investigators reported an incidence of 27% to 95% [13].…”

Section: Discussionsupporting

confidence: 45%

“…There is a variability of hearing loss incidence, once it has influence of radiation technique (2D or 3D) and dose, anticancer drugs and dose, individual susceptibility and age [3,13]. In our research, all patients received, and 3D radiotherapy as prescribed by oncologist.…”

Section: Discussionmentioning

confidence: 93%

“…Indeed, investigators reported hearing loss at high frequencies [5,8,23]. Only radiotherapy as head and neck cancer treatment reported hearing loss at frequencies above 4kHz [13].…”

Section: Discussionmentioning

confidence: 99%

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Cancer treatment: changes in hearing thresholds

Machado¹,

Amaral²,

Aguiar³

et al. 2018

Oncol Res Rev

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Purpose: Evaluate changes in hearing thresholds in patients undergoing cancer treatment.Method: Prospective, longitudinal study carried out at Cancer Center of a Sergipe´s public hospital, Brazil. Audiological evaluation (Conventional Pure Tone Audiometry) have been performed in 20 patients following eight weeks of cancer treatment (reference exam) and 20 weeks (sequential exam) of treatment. All survivors had normal hearing thresholds before cancer treatment. The procedure has been approved by the Ethics in Research Committee, under protocol # 33665014.7.0000.5546.Results: Head and neck cancer displayed oncology highest incidence (35%). Referential exam, eight weeks before treatment, displayed 15% with sensorineural hearing loss and 17.5% at second tests. It was observed a slight worsening for all test frequencies of referential and sequential exam. Tinnitus was the biggest complaint (81.3%), but there was no statistic correlation between hearing loss (p=0.89). Conclusion:Hearing monitoring form this small sample suggest chemotherapy and radiotherapy treatments can have a detrimental effect on hearing thresholds significate for 2 to 8kHz eight weeks after cancer treatment and 4 to 8kHz 20 weeks before.

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Section: Discussionsupporting

confidence: 45%

Section: Discussionmentioning

confidence: 93%

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Cancer treatment: changes in hearing thresholds

Machado¹,

Amaral²,

Aguiar³

et al. 2018

Oncol Res Rev

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“…The permanent effect of radiotherapy on hearing is sensorineural hearing loss (SNHL) caused by radiation damage to the inner ear. 5 However, intensitymodulated radiotherapy may spare the cochlea the effects of high-dose radiotherapy, thereby reducing the incidence of radiotherapy-induced SNHL. 6 Apart from radiotherapy, cisplatin is also known to cause permanent SNHL starting immediately after the first cisplatin infusion.…”

mentioning

confidence: 99%

Prediction of Hearing Loss Due to Cisplatin Chemoradiotherapy

Theunissen

Zuur

Jóźwiak

et al. 2015

JAMA Otolaryngol Head Neck Surg

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“…[5,6] and it was observed that patients who had hearing loss primarily had bilateral symmetric sensorineural hearing loss [7]. Moreover, one recent systematic review has also indicated that patients receiving radiotherapy for head and neck tumors could be at risk of developing sensorineural hearing loss, although high-quality research is still lacking [8]. Genes such as DFNA5 could also play a role in the etiology of hearing loss while involving cancer [9].…”

Section: Main Findingsmentioning

confidence: 99%

Chronic diseases and life events accounted for 2–18 % population attributable risks for adult hearing loss: UK Adult Psychiatric Morbidity Survey, 2007

Ivy¹

2015

Eur Arch Otorhinolaryngol

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Links between chronic diseases and hearing loss in adults have emerged. However, previous investigations were not complete, and the role of life events was unclear. Therefore, it was aimed to examine the relationships of common chronic diseases and life events and adult hearing loss in a country-wide and population-based study. Data were retrieved from UK Adult Psychiatric Morbidity Survey, 2007, being cross-sectional, including demographics, self-reported prior health conditions and hearing loss (ever and in the last 12 months), and several major life events. Analyses included Chi square test, t test, logistic regression model, and population attributable risk estimation. People who had prior health conditions including cancer, migraine, dementia, depression, cataracts, chronic bronchitis, allergy, bowel problem, bladder problem, arthritis, muscle problem or skin problem tended to report hearing loss than their counterparts. People who have experienced major life events including post-traumatic stress disorder, serious illness of close relatives, death of family, serious problems with friends, major financial crisis, valuables stolen, being bullied, violence at home, sexual abuse or running away from home were also more likely to experience ever hearing loss problem or that in the last 12 months. 2.0-13.1 % adult hearing loss could be delayed or prevented by managing chronic diseases while 4.1-18.1 % might be delayed or prevented by minimizing the negative effects of life events. Chronic diseases and life events were associated with hearing loss in adults. Better managing lifestyle to minimize detrimental impacts in future health and nursing programs would be suggested.

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Characteristics of radiation-induced sensorineural hearing loss in head and neck cancer: A systematic review

Abstract: High quality literature in the topic is lacking. Radiation-induced SNHL is progressive, permanent, and dose-dependent. Total dose and follow-up time are important factors affecting incidence rates.

Cited by 61 publications

References 34 publications

Cancer treatment: changes in hearing thresholds

Cancer treatment: changes in hearing thresholds

Prediction of Hearing Loss Due to Cisplatin Chemoradiotherapy

Chronic diseases and life events accounted for 2–18 % population attributable risks for adult hearing loss: UK Adult Psychiatric Morbidity Survey, 2007

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