Characteristics of respiratory virus infections in autologous hematopoietic stem cell transplantation patients, a prospective study, Bern, Switzerland, 2015–2017

Respiratory Syncytial Virus Infections in Recipients of Bone Marrow Transplants: A Systematic Review and Meta-Analysis

“…Qualitative and quantitative analyses were therefore performed on a final pool of 30 papers, whose content is summarized in Table 2 [46,51,61,68,70,, all of them published from 1999 to 2022, and including series from 1989 to 2021. More precisely, seven studies were published before 2005 [51,70,84,86,91,94,101], thirteen between 2005 and 2014 [46,68,80,82,[88][89][90]92,93,95,97,100,104], and seven between 2015 and 2019 [61,81,83,87,98,102,103], while only three studies had been published since 2020 [85,96,99]. The pooled sample encompassed a total of 20,067 BMT cases (130,622.81 person-years), 821 cases of RSV infections (crude incidence rate 4.09%, and 6.285 per 1000 person-years), and 78 RSV-related deaths (crude mortality, 3.887 deaths per 1000 BMT cases and 0.597 deaths per 1000 person-years; crude CFR 9.50%) [46,51,61,68,70,.…”

“…The largest share of reports (11 out of 30, 36.67%) was obtained from the United States [61,81,83,84,86,89,92,98,100,101,104], and included more than half of total BMT cases (12,777; 63.67%). Three further studies reported on BMT cases from the UK [51,94,97] (7.32% of total BMT cases), and there were two studies each from Canada [46,87] (6.50% of total BMT cases), Germany [68,70], South Korea [82,90], and Switzerland [88,96] (1.81%, 0.87%, and 2.78% of total BMT cases, respectively). The remaining reports were from mainland China [99,103], India [79], Italy [95], Mexico [85], Singapore [102], Spain [93], and Sweden [80], with a multi-country study [91] on 37 BMT centers and 1972 cases (9.83% of total cases) across Europe.…”

“…Most available reports were based on a single center with a retrospective design, with only three multicenter reports (for a total of 5055 BMT cases, 25.19% of the total sample) [83,91,98] and five prospective studies (660 BMT cases, 3.29%) [85,89,95,96,99]. Among the collected studies, 24 provided the proportion of allogenic BMT (65.21% of the total sample), while this information was not included in 6 studies for a total of 7047 BMT cases [84,89,92,[97][98][99] (Table 3).…”

“…Among the collected studies, 24 provided the proportion of allogenic BMT (65.21% of the total sample), while this information was not included in 6 studies for a total of 7047 BMT cases [84,89,92,[97][98][99] (Table 3). Similarly, the proportion of pediatric cases was provided by 22 studies [46,51,61,68,[81][82][83][85][86][87]90,[92][93][94][95][96]98,99,[101][102][103][104], for a total of 5936 subjects (29.58% of the total sample). Note: S = single center; M = multi-center; P = prospective; R = retrospective; NA = not available/not provided; BMT = bone marrow transplantation; CFR = case fatality ratio; LRTI = lower respiratory tract infections; Flu = influenza virus infection; RSV = respiratory syncytial virus infection; HAdV = adenovirus infection; hMPV = human metapneumovirus infection.…”

Influenza Vaccination Programs for Healthcare Personnel: Organizational Issues and Beyond

“…A recent study compiling influenza-associated excess respiratory mortality estimates from 31 countries representing five World Health Organization (WHO) regions from 1999–2015, estimated that every year an average of 389,000 (range: 294,000–518,000) respiratory deaths globally are associated with influenza [ 1 ]. Although infection control capacity has largely improved in healthcare facilities the past decade, healthcare-associated influenza and outbreaks are common, even among high-risk patients [ 2 , 3 , 4 ]. Recent studies indicate that healthcare-associated influenza is a major component of the burden of influenza in healthcare facilities, accounting for up to 17.3% of influenza cases with considerable range from season to season [ 5 , 6 ].…”