Characteristics of retinal vessels in surgically closed macular hole: an optical coherence tomography angiography study

Yun, Cheolmin; Ahn, Jaemoon; Kim, Mingue; Kim, Jee Taek; Hwang, Soon Young; Kim, Seong-Woo; Oh, Jaeryung

doi:10.1007/s00417-017-3742-6

Cited by 22 publications

(12 citation statements)

References 51 publications

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“…Similar to FAZ, also the retinal VD of SCP and DCP was associated with postoperative retinal thickness, and in particular, with mean GCL-IPL thickness [72]. An issue that has been raised with repeated FAZ and VD measurements before and after MH closure deals with macular displacement secondary to ILM peeling.…”

Section: Macular Perfusionmentioning

confidence: 99%

Inner Retinal Layer and Outer Retinal Layer Findings after Macular Hole Surgery Assessed by means of Optical Coherence Tomography

Cicinelli

Marchese

Bandello

et al. 2019

Journal of Ophthalmology

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Aim. To summarize the spectrum of optical coherence tomography (OCT) and OCT angiography (OCTA) features after full-thickness macular hole (MH) repair surgery. Methods. A PubMed engine search was carried out using the terms “Macular Hole,” “Optical Coherence Tomography,” and “Optical Coherence Tomography Angiography.” All reports published in English up to October 2018, irrespective of their publication status, were included. Tomographic signs analyzed were divided according to the involved portion of the retina in “inner retinal layers” and “external retinal layers.” Despite predominantly involving the inner retinal layers, cystoid macular edema (CME) has been treated as a separate entity. Finally, report on vessel density (VD) changes and the foveal avascular zone (FAZ) area modifications have been included. Results. Different clinical findings can be observed on OCT of patients who underwent MH repair surgery. There is general consent that retinal thinning involving primarily the retinal nerve fiber layer and the ganglion cell layer takes place after surgery. In the postoperative period, the outermost retinal layers get progressively restored. Persistent defects in the ellipsoid zone or in the external limiting membrane correlate with worse postoperative visual outcome. OCTA has globally demonstrated that eyes after MH closure show a reduction in macular and paramacular VD and smaller FAZ areas, compared with control or fellow eyes. Conclusion. Clinicians should be aware of the most common tomographic findings to properly manage each condition. In addition, significant advantages for the postoperative application of OCT and OCTA include noninvasiveness, rapid and simple execution, repeatability, and precise measurements.

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Section: Macular Perfusionmentioning

confidence: 99%

Inner Retinal Layer and Outer Retinal Layer Findings after Macular Hole Surgery Assessed by means of Optical Coherence Tomography

Cicinelli

Marchese

Bandello

et al. 2019

Journal of Ophthalmology

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“…These changes suggest that retinal morphologic remodeling occurs during the recovery process after MH surgery. Retinal vessels are another important component of the retinal structure and are known to be involved in the development and healing of retinal diseases 43…”

Section: Introductionmentioning

confidence: 99%

<p>Optical coherence tomography angiography features in patients with idiopathic full-thickness macular hole, before and after surgical treatment</p>

Wilczyński¹,

Heinke²,

Niedzielska-Krycia³

et al. 2019

CIA

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PurposeTo present optical coherence tomography (OCT) angiography features in patients with idiopathic full-thickness macular hole before and after vitrectomy.Study designProspective case series study.Materials and methodsPatients presenting with an idiopathic full-thickness macular hole (IMH) who underwent posterior vitrectomy with internal limiting membrane peeling and gas tamponade were included in the study. En face OCT and OCT angiography (OCTA) was performed pre- and postoperatively using 3×3 mm scans (Optovue, XR Avanti). Foveal avascular zone (FAZ) area, macular hole size (MHS), central retinal thickness (CRT), macular parafoveal choriocapillary flow area (MCFA), and fovea vessel density (FVDS) were measured and assessed using OCTA. Best-corrected visual acuity (BCVA) was examined before and 3 months after surgery.ResultsTwenty-eight eyes of 28 patients were included in the study. The mean age of patient group was 68.28 years. The hole was closed in all eyes after the initial surgery. OCTA showed enlargement of FAZ and increased CRT in foveal area. Mean preoperative FAZ area was 0.39±0.07 mm2. En face images of the middle retina showed a range of preoperative cystic patterns surrounding the hole. BCVA was improved from 0.1±0.11 preoperatively to 0.42±0.17 postoperatively. Mean FAZ area was reduced to 0.24±0.07 mm2 postoperatively with resolution of macular hole and adjacent cystic areas. Mean CRT was reduced from 396±62.6 µm pre-operatively to 272±30.7 µm postoperatively. After vitrectomy, the parafoveal choriocapillary flow area and FVDS of IMH eyes increased compared with the preoperative measurements.ConclusionQuantitative evaluation of vascular and morphological changes following IMH surgery using OCTA shows the potential for recovery due to vascular and neuronal plasticity. OCTA showing vascular changes and their quantitative characteristics might be a useful tool for the assessment of macular holes before and after surgical treatment.

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“…Recent advances in OCT angiography technologies make it possible to delineate vascular and nonvascular components in the retina and choriocapillaris layers. 12,13 OCT angiography also provides depth-resolved information and detailed images of choroidal neovascularization (CNV) in neovascular AMD (nAMD). 14 In addition, choriocapillaris flow has been determined using OCT angiography.…”

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confidence: 99%

Variation of Retinal and Choroidal Vasculatures in Patients With Age-Related Macular Degeneration

Lee

Ahn

Yun

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To investigate variations in chorioretinal vasculatures in fellow eyes of patients with unilateral neovascular age-related macular degeneration (nAMD). METHODS. We included fellow eyes of consecutive patients with unilateral nAMD from swept source optical coherence tomography (SS-OCT) angiography database. Vascular and nonvascular indices were determined based on SS-OCT and SS-OCT angiography images. Variation of the vascular or nonvascular index was compared between fellow eyes with and without early AMD. RESULTS. In 146 fellow eyes, 88 (60.3%) had early AMD and 58 (39.7%) had a normal fundus. Vascular density (VD) values of the superficial and deep retinal capillary plexus and choriocapillaris were smaller in eyes with early AMD than in those without (P < 0.001, P ¼ 0.001, P ¼ 0.006, respectively). Flow void area in choriocapillaris was greater in eyes with early AMD than those without (P ¼ 0.015). In 88 fellow eyes with early AMD, vascular indices of the retina were correlated with those of choroid while nonvascular indices were not. Fellow eyes of patients with classic exudative AMD had greater foveal avascular zone area and smaller VD values of the deep retinal capillary plexus than those with polypoidal choroidal vasculopathy (P < 0.001, P ¼ 0.004). CONCLUSIONS. In addition to vascular insufficiency in the choroid or choriocapillaris, retinal vascular alteration was apparent in eyes with early AMD. It may suggest that retinal vessels were involved in the pathogenesis of AMD even while changes in nonvascular components of the retina were not yet apparent.

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Characteristics of retinal vessels in surgically closed macular hole: an optical coherence tomography angiography study

Abstract: Surgically closed MH eyes had remodeled retinal vascular patterns, which were related to morphologic changes in the inner retinal layer. The healing process after MH surgery may be involved in asymmetric change in anatomy and hemodynamics of the inner retina.

Cited by 22 publications

References 51 publications

Inner Retinal Layer and Outer Retinal Layer Findings after Macular Hole Surgery Assessed by means of Optical Coherence Tomography

Inner Retinal Layer and Outer Retinal Layer Findings after Macular Hole Surgery Assessed by means of Optical Coherence Tomography

<p>Optical coherence tomography angiography features in patients with idiopathic full-thickness macular hole, before and after surgical treatment</p>

Variation of Retinal and Choroidal Vasculatures in Patients With Age-Related Macular Degeneration

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