Characteristics of Sarcopenia in Patients with Heart Failure

Obata, Hiroaki; Izumi, Toru; Mitsuma, Wataru; Tomii, Asako; Sakai, Katsuyuki; Uehara, Akifumi; Watanabe, Tohru; Kashimura, Takeshi; Hanawa, Haruo; Minamino, Tohru

doi:10.1016/j.cardfail.2014.07.171

Cited by 1 publication

(5 citation statements)

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“…Obata et al reported a prevalence of 45.5% for muscle wasting in heart failure patients aged under 65 years. 3 Although the prevalence of muscle wasting in the Obata et al study is similar to our study, considering the lower mean of age in our study (37.3 ± 10.1), it seems that muscle wasting would be more prevalent in Iranian population.…”

Section: Discussionsupporting

confidence: 81%

“…18 In another study in Japan, 57% of heart failure patients between 43 and 90 years showed evidence of sarcopenia. 3 In a cohort of 200 patients with heart failure and a mean age of 70 years, the prevalence of sarcopenia was about 19.5%. 4 In this study, we aimed to evaluate the presence of muscle wasting in younger patients with heart failure.…”

Section: Discussionmentioning

confidence: 99%

“…1,[6][7][8] In most studies regarding muscle wasting in heart failure, elderly patients have been selected. [2][3][4][5]9 The results of these studies indicate a higher prevalence of muscle wasting in older patients with heart failure compared with healthy subjects who are at the same age. [2][3][4][5]9 There are only scant data regarding the presence of muscle wasting in younger patients with heart failure, 3 and it is not known whether heart failure could possibly be a risk factor for muscle wasting regardless of ageing process or not.…”

Section: Introductionmentioning

confidence: 85%

“…However, there is no consensus with regard to the precise age range for this syndrome. [1][2][3]6,9,[12][13][14][15][16] After the first definition of sarcopenia by Irwin Rosenberg, many investigators have studied different aspects of this phenomenon in different subgroups of population including healthy persons and patients suffering from chronic illnesses like chronic heart failure or renal failure. 4,6,7,[12][13][14]17 Akiyama et al presented a prevalence of 20% for muscle wasting in patients over 70 years who were admitted with acute heart failure.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 The adaptive changes in musculoskeletal system following the occurrence of heart failure play key roles in the development of many symptoms related to heart failure syndrome including exercise intolerance and fatigue. [1][2][3][4][5] Although muscle wasting was first introduced as a phenomenon secondary to ageing, it is more prevalent in patients with a chronic illness such as heart failure, chronic renal failure, and chronic lung disease. 1,[6][7][8] In most studies regarding muscle wasting in heart failure, elderly patients have been selected.…”

Section: Introductionmentioning

confidence: 99%

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Muscle wasting in young patients with dilated cardiomyopathy

Hajahmadi

Shemshadi

Khalilipur

et al. 2017

J cachexia sarcopenia muscle

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BackgroundMuscle wasting can be accelerated by chronic diseases such as heart failure and is one of the major causes of disability, morbidity, and mortality in this population. We aimed to investigate the incidence of muscle wasting and its associated factors in dilated cardiomyopathy patients younger than 55 years of age.MethodsBetween April 2014 and December 2015, all symptomatic patients with a diagnosis of non‐ischaemic dilated cardiomyopathy who were referred to heart failure clinic were included in our study.Dual energy X‐ray absorptiometry was used to evaluate body composition and identify muscle wasting. Muscle mass was calculated as the ratio of an individual's total lean mass of legs and arms (also called appendicular skeletal muscle) to their squared height (kg/m2). The muscle mass values of less than 5.45 kg/m2 for women and 7.26 kg/m2 for men were considered low.ResultsA total of 55 patients (32 male) were included. The mean (standard deviation) of age was 37.3 (10.1) years, and the mean of left ventricular ejection fraction was 21.4%. Most of the patients were in the New York Heart Association classes of II and II–III. Twenty‐six patients (47.3%) met criteria for muscle wasting. Patients with muscle wasting had lower left ventricular ejection fraction, lower 6‐min walk distance, and higher New York Heart Association function class and hospitalization rate.ConclusionsWe concluded that muscle wasting might be present in younger patients with heart failure, particularly in those who are in worse clinical condition.

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Section: Discussionsupporting

confidence: 81%