Characteristics of serogroup ANeisseria meningitidis strains isolated in the Central African Republic in February 1992

Guibourdenche, M.; Caugant, Dominique A.; Hervé, Vincent; Debonne, Jean-Marc; Lanckriet, C; Merlin, Mark A.; Mathiot, C; Roungou, J. B.; Martet, G.; Riou, J.Y.

doi:10.1007/bf01982194

Cited by 17 publications

(9 citation statements)

References 11 publications

(7 reference statements)

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“…Epidemics caused by subgroup III have continued to spread in Africa since the Mecca outbreak of 1987 (Nejmi et al, 1992;Guibourdenche et al, 1994;Auriol et al, 1995). The opaB94, opaD100, iga3 and ᮊ 1997 Blackwell Science Ltd, Molecular Microbiology, 25, 1047-1064 Fig.…”

Section: Genetic Fixation Within Subgroup IIImentioning

confidence: 99%

Clonal descent and microevolution of Neisseria meningitidis during 30 years of epidemic spread

Morelli

Malorny

Müller

et al. 1997

Molecular Microbiology

102

141

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SummarySerogroup A meningococci of subgroups III, IV-1 and IV-2 are probably descended from a common ancestor that existed in the nineteenth century. The 10.5 kb sequences spanning five distinct chromosomal loci, encoding cell-surface antigens, a secreted protease or housekeeping genes and intergenic regions, were almost identical in strains of those subgroups isolated in 1966, 1966 and 1917 respectively. During the subsequent two to three decades, all of these loci varied as a result of mutation, translocation or import of DNA from unrelated neisseriae. Thus, microevolution occurs frequently in naturally transformable bacteria. Many variants were isolated only once or within a single geographical location and disappeared thereafter. Other variants achieved genetic fixation within months or a few years. The speed with which sequence variation is either eliminated or fixed may reflect sequential bottlenecks associated with epidemic spread and contrasts with the results of phylogenetic analyses from bacteria that do not cause epidemics.

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Section: Genetic Fixation Within Subgroup IIImentioning

confidence: 99%

Clonal descent and microevolution of Neisseria meningitidis during 30 years of epidemic spread

Morelli

Malorny

Müller

et al. 1997

Molecular Microbiology

102

141

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“…A study of meningococcal carriage was performed in July 1989 in a military camp situated in the region of Casablanca, and a carriage rate of 4-3 % was observed [25]. All the 65 strains isolated were identical and represented a clone of subgroup III identified in 2 of the 25 patients from Morocco in 1989 included in this study (Guibourdenche and Riou, unpublished data [26] and the resurgence of clone 111-1 in the Central African Republic in the early 1992 [21], suggesting that with the exception of the epidemic in Niger, this 2-year period was marked by low incidence of disease.…”

Section: Electrophoresis Of Enzymesmentioning

confidence: 95%

“…Clone identification and other characteristics of the strains Table 2 summarizes the origin and the characteristics of the 125 patient strains examined. The analysis of the 24 strains from the Central African Republic has been published elsewhere [21]. All but 6 of the strains (95 %) were serogroup A.…”

Section: Electrophoresis Of Enzymesmentioning

confidence: 99%

Epidemics of serogroup ANeisseria meningitidisof subgroup III in Africa, 1989–94

Guibourdenche

Høiby²,

Riou

et al. 1996

Epidemiol. Infect.

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SUMMARYA total of 125 strains of Neisseria meningitidis recovered in the course of outbreaks from patients with systemic disease in 11 African countries between 1989 and 1994 were analysed by serogrouping, serotyping and multilocus enzyme electrophoresis. Of the 125 patient strains 115 (92 %) belonged to the clone-complex of serogroup A meningococci, designated subgroup III. Among the remaining strains, 4 were also serogroup A, but belonged to the clonal groups I and IV-1 (2 strains each), whilst 6 strains (4 serogroup C and 2 serogroup W135) represented clones of the ET-37 complex. Our results indicated that the second pandemic caused by clones of subgroup III is still spreading in Africa. Towards the West it has reached Niger, Mali, Guinea and The Gambia, and towards the South, the Rwanda, Burundi, Tanzania and Zambia.

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“…Serogroupprogressed from the eastern countries of the meningitis belt ing was performed by using slide agglutination testing with (Sudan, Chad, and Ethiopia) [11,15,16] to Kenya [17], rabbit antiserum (Murex Diagnostics, Dartford, United KingUganda, and Tanzania [18] in 1989, the Central African Repubdom) to capsular polysaccharide. MICs of penicillin were deterlic in 1992 [19], Zambia in 1993 [6], and Angola in 1995 mined by the broth microdilution method as specified by the (D. A. Caugant, unpublished data). This clone continues to National Committee for Clinical Laboratory Standards [20].…”

Section: Meningitis and Meningococcemia Caused By Neisseria Men-mentioning

confidence: 99%

Epidemic Spread of Subgroup III ofNeisseria meningitidisSerogroup A to South Africa in 1996

McGee¹,

Koornhof²,

Caugant³

1998

CLIN INFECT DIS

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A total of 111 strains of Neisseria meningitidis isolated during a meningitis outbreak in Johannesburg, South Africa, in 1996 were analyzed by serogrouping, arbitrarily primed polymerase chain reaction analysis, ribotyping, and multilocus enzyme electrophoresis. Nineteen different clusters were identified, and typing patterns for the three techniques were comparable. Of the 111 strains analyzed, 55 (49.5%) belonged to the serogroup A clone complex designated internationally as subgroup I-1. The second largest cluster included 15 isolates (13.5%) that were identified as belonging to the pandemic clone III-1. A number of unrelated strains were also encountered. Our study provides the first documented evidence of the presence of clone III-1 in South Africa and indicates the continued spread of this clone well outside the African meningitis belt.

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Characteristics of serogroup ANeisseria meningitidis strains isolated in the Central African Republic in February 1992

Cited by 17 publications

References 11 publications

Clonal descent and microevolution of Neisseria meningitidis during 30 years of epidemic spread

Clonal descent and microevolution of Neisseria meningitidis during 30 years of epidemic spread

Epidemics of serogroup ANeisseria meningitidisof subgroup III in Africa, 1989–94

Epidemic Spread of Subgroup III ofNeisseria meningitidisSerogroup A to South Africa in 1996

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