Characteristics of subthalamic oscillatory activity in parkinsonian akinetic-rigid type and mixed type

Feng, Hongliang; Zhuang, Ping; Hallett, Mark; Zhang, Yuqing; Li, Jianyu; Li, Yongjie

doi:10.3109/00207454.2015.1074225

Cited by 10 publications

(16 citation statements)

References 40 publications

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“…40,41 In our previous study, βFB has also been directly correlated with rigidity. 16 In other studies, a direct relationship between basal ganglia oscillations and tremor has been found. 22,42 The TFB oscillations are tremor coherent in more than 50% of STN neurons.…”

Section: Discussionmentioning

confidence: 78%

“…As described in previous studies, 16,23 microelectrode recordings were performed during targeting using the Microguide system Pro (AlphaOmega Engineering, Nazareth, Israel) with patients at rest as a general step in the targeting procedure. Briefly, a tungsten microelectrode with tip size 10-20 μm and resistances from 0.3 to 0.5 MΩ at 1000 Hz (Alpha Omega Engineering, Nazareth, Israel) was used.…”

Section: Microelectrode Recordingmentioning

confidence: 99%

“…12,14,15 When it comes to oscillatory activity, the β band oscillatory neurons are the most well studied, and based on the evidence, βFB activity has been associated with bradykinesia and rigidity. 16 TFB associated oscillation has been correlated with limb tremor. 17 As the disease progresses, tremor tends to be less severe while rigidity and bradykinesia may become the dominant problem.…”

Section: Introductionmentioning

confidence: 99%

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<p>Asymmetry of Subthalamic Neuronal Firing Rate and Oscillatory Characteristics in Parkinson’s Disease</p>

Zhao

Zhuang

et al. 2020

NDT

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Purpose: The aim of this study was to compare the neuronal firing rate and oscillatory activity of the subthalamic nucleus (STN) between the more affected (MA) and the less affected (LA) hemispheres in Parkinson's disease (PD). Patients and Methods: We recorded and analyzed the intra-operative microelectrode recordings (MER) from the STN of 24 PD subjects. Lateralized Unified Parkinson's Disease Rating Scale (UPDRS) III sub-scores (item 20-26) were calculated. The STN corresponding to the MA side was designated as the MA STN while the other side as the LA STN. Single unit characteristics including interspike intervals were identified and spectral analyses were assessed. Further, the mean spontaneous firing rate (MSFR) of neurons was calculated. The correlations between clinical symptoms and neuronal activity were analyzed. Results: The firing rate in the MA and LA sides were 43.18 ± 0.74 Hz and 36.94 ± 1.32 Hz, respectively, with an increase of 16.9% in the MA group. The number of neurons that oscillated in the Tremor-Frequency Band (TFB), β-Frequency Band (βFB), and the nonoscillatory cells in the MA group were 43, 115, and 62 versus 78, 68, and 54 in the LA group, respectively. The proportions of the three types of neurons were different between both groups. The firing rate of the STN neurons and the UPDRS III sub-scores were positively correlated. Additionally, we observed a positive correlation between the percentage of βFB oscillatory neurons and bradykinesia score. Conclusion: The firing rate of the STN in the MA hemisphere is higher than in the LA side, following disease progression and there seems to be an increase in firing rate. The βFB oscillatory neurons are at a larger proportion in the MA group while there were larger percentage of TFB oscillatory cells in the LA group. The proportion of βFB oscillatory neurons is selectively correlated with the severity of bradykinesia.

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Section: Discussionmentioning

confidence: 78%

Section: Microelectrode Recordingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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<p>Asymmetry of Subthalamic Neuronal Firing Rate and Oscillatory Characteristics in Parkinson’s Disease</p>

Zhao

Zhuang

et al. 2020

NDT

Self Cite

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“…While dopamine loss is, in some way, related to the expression of tremor, this parkinsonian sign is often less sensitive to dopamine replacement therapy than the other parkinsonian signs, and not strongly related to beta-band power in LFP signals recorded in the basal ganglia [163].…”

Section: Pathophysiology Of Parkinsonism and Dystoniamentioning

confidence: 99%

“…It is thought that the overly strong beta-band LFP oscillation indicates that desynchronization processes of neurons within the circuitry fail in PD, which may contribute to the hypokinetic features of the disease. This has led to the proposal that beta-band LFP oscillations are antikinetic and strongly correlated with rigidity and bradykinesia [163], while gamma-band oscillations (a sign of desynchronization) are thought to be prokinetic [162]. Beta oscillations are viewed as normal for the resting or Bidling^state; their reduction with movement onset may play a role in allowing movement to take place.…”

Section: Pathophysiology Of Parkinsonism and Dystoniamentioning

confidence: 99%

Deep Brain Stimulation for Movement Disorders of Basal Ganglia Origin: Restoring Function or Functionality?

2016

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Deep brain stimulation (DBS) is highly effective for both hypo-and hyperkinetic movement disorders of basal ganglia origin. The clinical use of DBS is, in part, empiric, based on the experience with prior surgical ablative therapies for these disorders, and, in part, driven by scientific discoveries made decades ago. In this review, we consider anatomical and functional concepts of the basal ganglia relevant to our understanding of DBS mechanisms, as well as our current understanding of the pathophysiology of two of the most commonly DBS-treated conditions, Parkinson's disease and dystonia. Finally, we discuss the proposed mechanism(s) of action of DBS in restoring function in patients with movement disorders. The signs and symptoms of the various disorders appear to result from signature disordered activity in the basal ganglia output, which disrupts the activity in thalamocortical and brainstem networks. The available evidence suggests that the effects of DBS are strongly dependent on targeting sensorimotor portions of specific nodes of the basal gangliathalamocortical motor circuit, that is, the subthalamic nucleus and the internal segment of the globus pallidus. There is little evidence to suggest that DBS in patients with movement disorders restores normal basal ganglia functions (e.g., their role in movement or reinforcement learning). Instead, it appears that high-frequency DBS replaces the abnormal basal ganglia output with a more tolerable pattern, which helps to restore the functionality of downstream networks.

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Clinical asymmetry in Parkinson’s disease is characterized by prevalence of subthalamic pause-burst neurons and alpha-beta oscillations

Pavlovsky,

Sayfulina,

Gamaleya

et al. 2024

Clinical Neurophysiology

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Characteristics of subthalamic oscillatory activity in parkinsonian akinetic-rigid type and mixed type

Abstract: The STN βFB oscillatory neurons correlate with parkinsonian rigidity-bradykinesia. The high proportion of βFB oscillatory neurons found in the AR type of PD is indirect evidence for their importance in generating motor impairment.

Cited by 10 publications

References 40 publications

<p>Asymmetry of Subthalamic Neuronal Firing Rate and Oscillatory Characteristics in Parkinson’s Disease</p>

<p>Asymmetry of Subthalamic Neuronal Firing Rate and Oscillatory Characteristics in Parkinson’s Disease</p>

Deep Brain Stimulation for Movement Disorders of Basal Ganglia Origin: Restoring Function or Functionality?

Clinical asymmetry in Parkinson’s disease is characterized by prevalence of subthalamic pause-burst neurons and alpha-beta oscillations

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