Characteristics of T cell premature senescence in maintenance hemodialysis patients

Wu, Wangshu; Song, Ahui; Xie, Kewei; Lu, Jiayue; Zhao, Bingru; Qian, Cheng; Wang, Minzhou; Min, Lulin; Hong, Wenkai; Pang, Huihua; Lu, Renhua; Gu, Leyi

doi:10.1007/s00011-024-01897-2

Inflamm. Res.

2024

DOI: 10.1007/s00011-024-01897-2

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Characteristics of T cell premature senescence in maintenance hemodialysis patients

Wangshu Wu,

Ahui Song,

Kewei Xie

et al.

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2024

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Cited by 2 publications

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Inflammatory index is a promising biomarker for maintenance hemodialysis patients with cardiovascular disease

Han,

Zhang,

Kong

et al. 2024

Eur J Med Res

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Background and objectives Maintenance hemodialysis (MHD) patients are at a higher risk of cardiovascular disease (CVD), a common complication and leading cause of death. Persistent micro-inflammation is a unique feature of MHD. Given the established role of inflammation in the pathogenesis of atherosclerosis, this study aims to explore whether novel inflammatory markers (inflammation index) can serve as independent risk factors for CVD in MHD patients. Methods A cross-sectional survey was conducted on patients from three dialysis centers, categorized into a CVD and non-CVD group based on medical history, laboratory tests, and physical examination. Fasting blood samples were collected from all participants for indicator testing. Results The analysis of 209 patients revealed that 104 had concurrent CVD. Patients in the CVD group were significantly older and exhibited higher anxiety and depression scores. Forward stepwise multivariate logistic regression results identified the inflammation index neutrophil-to-lymphocyte ratio (NLR) (OR = 1.27, 95% CI 1.082–1.491, P < 0.05) and systemic immune-inflammation index (SII) (OR = 1.001, 95% CI 1.0001–1.002, P < 0.05) as independent risk factors for CVD in MHD patients. Receiver operating characteristic (ROC) curve analysis demonstrated that SII, platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and NLR all possess predictive diagnostic values for CVD events in this patient population. Conclusions Hemodialysis centers can utilize simple and cost-effective inflammatory markers to proactively identify patients at risk of CVD. Future research into how inflammation contributes to CVD in MHD is required.

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Inflammatory index is a promising biomarker for maintenance hemodialysis patients with cardiovascular disease

Han,

Zhang,

Kong

et al. 2024

Eur J Med Res

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TH1 Cell Frequency and Neutrophil-to-Lymphocyte Ratio in Hemodialysis: Potential Contributions to Patient Monitoring

Rodrigues Barreto,

Monteiro,

Rocha

et al. 2024

Biomedicines

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Introduction: Patients undergoing hemodialysis (HD) often exhibit an impaired cellular immune response, which may contribute to an increased susceptibility to infections and other complications. Th1 cells, a subset of T-helper cells, play a crucial role in cellular immunity. However, the modulation of Th1 cells by HD treatment remains unclear. Objective: This study aims to investigate the levels of circulating T cells, especially Th1 cells, and the neutrophil-to-lymphocyte ratio (NLR) in HD patients. Methods: We recruited 26 HD patients and 10 healthy volunteers. Demographical data were collected, and peripheral blood samples were analyzed. Absolute blood cell counts were determined, and T-cell populations were identified using flow cytometry. Th1 cells were defined as IFN-γ-producing CD4+ T cells after in vitro activation, and NLR was calculated through the ratio between the neutrophil and lymphocyte counts measured in peripheral blood. Results: We have observed a significant decrease in Th1 subpopulation frequency in HD patients, as well as significant correlations between immunological and demographic parameters, among which are the NLR values and the absolute values of T-cell subsets. Conclusions: These results seem to clarify the role of Th1 cells in modulating the immune responses of hemodialysis-treated patients, potentially considering its frequency as an indicator for CKD development.

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Characteristics of T cell premature senescence in maintenance hemodialysis patients

Cited by 2 publications

References 45 publications

Inflammatory index is a promising biomarker for maintenance hemodialysis patients with cardiovascular disease

Inflammatory index is a promising biomarker for maintenance hemodialysis patients with cardiovascular disease

TH1 Cell Frequency and Neutrophil-to-Lymphocyte Ratio in Hemodialysis: Potential Contributions to Patient Monitoring

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