The objective: to build up models for the areas of infectious risk of tuberculosis spread in a big urban center, to evaluate the presence of objects and parameters influencing the probability of development of tuberculosis infection nudi.Subjects and Methods. A retrospective and prospective study was conducted from January 2021 to June 2022 in St. Petersburg TB Dispensary no. 5. The study was performed taking into account the results of field surveys, with subsequent processing of materials for the territory of Kalininskiy and Krasnogvardeyskiy Administrative Districts of St. Petersburg.Results. According to the multivariate analysis of certain parameters, it was found that adult population density was a statistically significant factor influencing the type of tuberculosis infection risk areas (aOR=1.0002; p=0.0002). The role of educational facilities density (aOR=0.9932; p=0.9), and detected cases of latent tuberculous infection (aOR=1.0837; p=0.6), was statistically insignificant.