Characteristics of the aging rat mandible

Bodner, Lipa; Gabor, Dan; Kaffe, I

doi:10.1016/s0167-4943(98)00108-3

Cited by 5 publications

(2 citation statements)

References 35 publications

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“…12,13 In addition, the most anterior point on the labial alveolar bone (Id) 14 and the point that was 2.8 mm distant from the Id on the labial surface (IdЈ) were used to measure the inclination of the lower incisors. These points were selected primarily for three reasons: (1) According to previous studies, 15,16 the circumference of the lower incisor of the rat is established in the basal tooth part, and, once established, it remains constant; (2) the line from Id to IdЈ was an almost straight line on the labial surface in all rats; and (3) according to our pilot study (n ϭ 5), the coefficient of variation of the measurement values in the angle of the Id-incisal edge line to the mandibular plane was significantly larger than in the angle of the Id-IdЈ line to the mandibular plane (Wilcoxon signed ranks test; P ϭ .043).…”

Section: Cephalometric Analysismentioning

confidence: 99%

Effects of Mandibular Advancement plus Prohibition of Lower Incisor Movement on Mandibular Growth in Rats

Taira

Iino

Kubota

et al. 2009

The Angle Orthodontist

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Introduction:To test the hypothesis that mandibular advancement with the use of a fixed functional appliance combined with prohibition of labial movement of the lower incisors will have no effect on mandibular growth in growing rats. Materials and Methods: Fifteen 4-week-old male rats were divided into fixed, unfixed, and control groups (n ϭ 5, each). Bite-jumping appliances were used in the fixed and unfixed groups. Sites of bone perforation and the lower incisors were connected with ligature wires in the fixed group. The ramus height, mandibular length, and inclination of lower incisors were examined for 4 weeks, and those values were compared among five intervals and three groups by through one-way analysis of variance models and the Bonferroni multiple comparison test for post hoc comparison. Results: Increases in ramus height and mandibular length during the experimental period were 1.5 mm and 2.5 mm in the fixed group, 1 mm and 1.5 mm in the unfixed group, and 1.2 mm and 1.9 mm in the control group, respectively. Growth of ramus height and growth of mandibular length in the fixed group were greater than in the unfixed and control groups during the experimental period. The inclination of lower incisors in the unfixed group was increased 8.0 degrees throughout the experimental period, which differed from results obtained in the other groups. Conclusions: Mandibular growth was accelerated effectively before and during the pubertal period in rats by mandibular advancement with a fixed functional appliance combined with prohibition of labial movement of the lower incisor.

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Section: Cephalometric Analysismentioning

confidence: 99%

Effects of Mandibular Advancement plus Prohibition of Lower Incisor Movement on Mandibular Growth in Rats

Taira

Iino

Kubota

et al. 2009

The Angle Orthodontist

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“…This study has shown not only age-related but also stress-related changes in the morphological characteristics of the mandible. Many studies have been published regarding the morphological changes of the mandible during normal development (Bodner et al, 1998;Franchi et al, 2001;Lee et al, 2001;Ramaesh and Bard, 2003;Radlanski et al, 2003;Monteiro and Reis, 2005;Tagliaro et al, 2006Tagliaro et al, , 2009Pessa et al, 2008;Leamy et al, 2008). However, it remains unclear how to precisely detect abnormal morphology.…”

Section: Discussionmentioning

confidence: 99%

Mathematical Analysis of Mandibular Morphogenesis by Micro‐CT‐Based Mouse and Alizarin Red S‐Stained‐Based Human Studies During Development

Rafiq

Udagawa

Lundh

et al. 2011

The Anatomical Record

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Prenatal development of the mandible is an important factor in its postnatal function. To examine quantitatively normal and abnormal developmental changes of the mandible, we here evaluated morphological changes in mineralizing mandibles by thin-plate spline (TPS) including bending energy (BE) and Procrustes distance (PD), and by Procrustes analyses including warp analysis, regression analysis, and discriminant function analysis. BE and PD were calculated from lateral views of the mandibles of mice or of human fetuses using scanned micro-computed tomography (CT) images or alizarin red S-stained specimens, respectively. BE and PD were compared (1) between different developmental stages, and further, to detect abnormalities in the data sets and to evaluate the deviation from normal development in mouse fetuses, (2) at embryonic day (E) 18.5 between the normal and deformed mandibles, the latter being caused by suturing the jaw at E15.5, (3) at E15.5 and E18.5 between normal and knockout mutant mice of receptor tyrosine kinaselike orphan receptor (Ror) 2. In mice, BE and PD were large during the prenatal period and small after postnatal day 3, suggesting that the mandibular shape changes rapidly during the prenatal and early postnatal periods. In humans, BE of the mandibles peaked at 16-19 weeks of gestation, suggesting the time-dependent change in the mandibular shape. TPS and Procrustes analyses statistically separated the abnormal mandibles of the sutured or Ror2 mutant mouse fetuses from the normal mandible. These results suggest that TPS and Procrustes analyses are useful for assessing the morphogenesis and deformity of the mandible. Anat Rec, 295:313-327, 2012 The mammalian mandible is a complex morphological structure formed by various morphogenetic components of different embryological origins. These morphogenetic components were assembled during development to form the final structure (Atchley, 1993). The mandible originates from cells of the neural crest that migrate to the first mandibular arch and form the embryonic mesenchyme, which later develops into skeletal, dental, and connective tissues. The mesenchymal cells aggregate and produce condensations before undergoing differentiation to produce the morphogenetic components of the mandible (Atchley and Hall, 1991). The mandible consists of two symmetrical halves (right and left), each formed by a dentary bone with four morphogenetic regions: the mandibular body (ramus) and three processes (coronoid, condylar, and angular).Establishing normative expectations for experimentally induced changes in size and shape will be an important innovation in three-dimensional (3-D) micro-computed tomography (CT)-based morphological assessments, especially in quantifying differences in the values of those parameters between sets of developing mandibles as a primary aim. Nondestructive methods such as micro-magnetic resonance imaging (Pieles et al., 2007) and micro-CT (Johnson et al., 2006;Boughner et al., 2008;Nagase et al., 2008;Parsons et al., 2008;Hallgrimss...

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