Characteristics of the articular syndrome in patients with infl ammatory bowel disease

Khusainova, G. M.; Долгушина, А. И.; Кузнецова, А. С.

doi:10.31146/1682-8658-ecg-178-6-95-100

jour

2020

DOI: 10.31146/1682-8658-ecg-178-6-95-100

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Characteristics of the articular syndrome in patients with infl ammatory bowel disease

G. M. Khusainova

А. И. Долгушина

А. С. Кузнецова

Abstract: The aim to study: To study the structure and clinical features of the course of joint damage as an extra-intestinal manifestation in patients with infl ammatory bowel diseases.Materials and methods: 332 patients with infl ammatory bowel diseases were questioned and examined, who applied to the gastroenterological offi ce and were hospitalized at the Chelyabinsk Regional Clinical Hospital from October 2017 to November 2019.Results: Joint syndrome was found in 94 (28.3%) patients with IBD, more often had an olig… Show more

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Cited by 2 publications

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Psoriatic arthritis (literature review)

Asfandiyarova,

Shilin

2024

Klinicist

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Psoriatic arthritis (PsA) is a chronic immune-inflammatory progressive disease of the musculoskeletal system observed in psoriasis, which affects the joints, spine and entheses; it occurs in the form of arthritis, dactylitis, enthesitis, and can also manifest as spondylitis or sacroiliitis. The etiology of PsA is unknown, but the pathogenesis has been studied in more detail. Under the influence of external factors, such as infectious agents (viruses, bacteria, fungi), neuropsychic stress, injuries, drugs, changes in intestinal microbiota, etc., genetically predisposed individuals experience activation of the immune system, both congenital and acquired. Currently, there are 5 clinical forms of PsA: predominantly lesion of the distal interphalangeal joints of the hands and feet, distal form; mutilating arthritis; psoriatic spondylitis; asymmetric mono-oligoarthritis; symmetrical polyarthritis, rheumatoid-like form. Along with the characteristic symptomsof skin and joint damage, patients with PsA note a decrease in the quality of life, general malaise, fever, enlarged lymph Review nodes, weight loss, signs of comorbid pathology (obesity, diabetes, cardiovascular diseases). Arthritis is accompanied by tendinitis, synovitis, enthesitis. Isolated spinal damage (psoriatic spondylitis) is rare, it is usually combined with peripheral arthritis, characterized by pain in the spine, dysfunction, curvature. Differential diagnostics are carried out with rheumatoid arthritis, gout, ankylosing spondylitis, polyosteoarthritis, infectious forms of joint damage, joint damage in chronic inflammatory bowel diseases. Treatment of PsA should include medication, physiotherapy and spa treatment. Usually, treatment of PsA begins with the use of such drugs as methotrexate, leflunomide, sulfasalazine, cyclosporine A; non-steroidal anti-inflammatory drugs and intra-articular administration of glucocorticosteroids are used as an auxiliary agent, they are classified as symptom-modifying drugs, they partially improve the patient’s quality of life, reduce pain, but have little effect on the progression of the pathological process. In the absence of an effect from previously conducted treatment and contraindications, genetically engineered biological drugs are used.

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Psoriatic arthritis (literature review)

Asfandiyarova,

Shilin

2024

Klinicist

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Studying zonulin levels in patients with inflammatory bowel disease and peripheral arthritis

Khusainova,

Nesmeyanova,

Dolgushina

et al. 2023

HERALD of North-Western State Medical University named after I.

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BACKGROUND: Currently, disruption of the barrier function of the intestinal mucosa is considered one of the key mechanisms in the pathogenesis of extraintestinal manifestations of inflammatory bowel diseases, especially damage to the musculoskeletal system. AIM: To study the relationship between the level of zonulin in blood serum and the parameters of the immune status in patients with inflammatory bowel diseases in combination with peripheral arthritis. MATERIALS AND METHODS: 97 patients with ulcerative colitis and Crohn’s disease have been examined, with peripheral arthritis verified in 47 patients; the control group included 50 patients without peripheral arthritis. Zonulin, tumor necrosis factor α, interleukin-1β, -10, -17A, -23 were determined in blood serum using standard kits for direct enzyme immunoassay. RESULTS: Patients with peripheral arthritis were younger with an earlier onset of inflammatory bowel diseases (p 0.001). When assessing the concentration of serum zonulin in the patients with and without arthritis, no significant differences have been found. In the patients with peripheral arthritis, zonulin concentration directly correlated with the level of interleukin-17A (r = 0.323; p = 0.039), interleukin-23 (r = 0.321; p = 0.041). CONCLUSIONS: According to the data obtained, the use of zonulin as a marker of peripheral arthritis in inflammatory bowel diseases is not recommended. Nevertheless, the correlation of zonulin and the concentrations of interleukin-17А and -23 demonstrates its role in the regulation of mucosal immunity in the development of extraintestinal manifestations of inflammatory bowel diseases.

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Characteristics of the articular syndrome in patients with infl ammatory bowel disease

Cited by 2 publications

References 16 publications

Psoriatic arthritis (literature review)

Psoriatic arthritis (literature review)

Studying zonulin levels in patients with inflammatory bowel disease and peripheral arthritis

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