Characteristics of the fibroplasia and collagen expression in the abdominal wall after implant of the polypropylene mesh and polypropylene/polyglecaprone mesh in rats

Biondo-Simões, Maria de Lourdes Pessole; Morais, Camila Gomes de; Tocchio, Anna Flávia Zonato; Miranda, Renata Augusta de; Moura, Paula Almeida Pamponet; Colla, Kelly; Robes, Rogério Ribeiro; Ioshii, Sérgio Ossamu; Tomasich, Flávio Daniel Saavedra

doi:10.1590/s0102-865020160050000001

Cited by 8 publications

(6 citation statements)

References 29 publications

(29 reference statements)

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“…Porosity is another key element regarding the expected tissue reaction [4]. The pores have to be wider than 75 µm in diameter to allow a proper macrophageal, fibroblastic and new blood vessel growth, as well as to let new fibers of collagen to engulf the mesh.…”

Section: Experimental Partmentioning

confidence: 99%

Textile Polypropylene Allografts and their Postoperative Tissue Reaction in the Surgery of Inguinal Hernia

Bratu¹,

Boicean²,

Tănăsescu³

et al. 2017

Mat.Plast.

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The usage of prosthetic devices in the surgery of parietal defect is, nowadays, essential for a good abdominal wall recovery and prevention of the hernia recurrence. A good and suitable textile allograft should poses one or more, ideally all, of the following characteristics: pliable, strong, non-allergenic and with perfect tissue integration behavior. The aim of this paper is to evaluate the immediate and long term tissue reaction of different textile allografts used in open surgery of inguinal hernia repair.

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Section: Experimental Partmentioning

confidence: 99%

Textile Polypropylene Allografts and their Postoperative Tissue Reaction in the Surgery of Inguinal Hernia

Bratu¹,

Boicean²,

Tănăsescu³

et al. 2017

Mat.Plast.

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“…Type I and type III collagen densities were increased in both groups however there were no significant differences in polypropilene and polypropylene/poliglecaprone group. 20 However collagen type I/III ratio and total collagen density were decreased in most incisional hernia patients, Meyer et al didn't report any differences for the average percent area of collagen (type I + type III) and the density of it. 21 This study contradict the other studies.The other important issue of incisional hernia repair is the layer for repair.…”

Section: Discussionmentioning

confidence: 96%

The effect of polypropylene mesh on different layers to the formation of collagen type I/ III ratio and total collagen density in incisional hernia repair

et al. 2018

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Background: In incisional hernia patients, collagen type I/III ratio and total collagen density (TCD) emerges a main etiological factor. If they are low, recurrence risk can be high. The aim of this study was to determine the ratio of collagen type I/III and TCD after incisional hernia repair in different layers with polypropylene mesh.Methods: In the study, 40 Wistar Albino rats were used. They were divided into four equal groups: control, preperitoneal, intraperitoneal and onlay. In control group, defect was repaired with prolene suture. In other groups, prolene mesh was placed to the different layers. Incisions were reopened 30 days later, and tissue samples were taken. Samples were stained by double-immunohistochemical methods and examined under light microscope.Results: Collagen type I/III ratio and TCD was highest in preperitoneal group. Intraperitoneal group was the second highest group. There was no difference between onlay and control group for collagen type I/III ratio except TCD. There was a significant correlation between TCD and collagen type I/III ratio in all samples.Conclusions: Mesh repair in different layers has an effect on TCD and collagen type I/III ratio in incisional hernia repair. Preperitoneal layer is better than other layers.

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“…Biondo-Simões et al . 26 carried out a comparative experimental study in Wistar rats with pre-peritoneal implants using two different types of mesh for correction of defects induced in the abdominal wall with maintenance of the integrity of the parietal peritoneum. They used a heavy-weight polypropylene mesh and a partially absorbable mesh composed of lightweight polypropylene with polyglecaprone.…”

Section: Discussionmentioning

confidence: 99%

Analysis of tissue inflammatory response, fibroplasia, and foreign body reaction between the polyglactin suture of abdominal aponeurosis in rats and the intraperitoneal implant of polypropylene, polypropylene/polyglecaprone and polyester/porcine collagen meshes

et al. 2021

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Purpose To compare tissue inflammatory response, foreign body reaction, fibroplasia, and proportion of type I/III collagen between closure of abdominal wall aponeurosis using polyglactin suture and intraperitoneal implant of polypropylene, polypropylene/polyglecaprone, and polyester/porcine collagen meshes to repair defects in the abdominal wall of rats. Methods Forty Wistar rats were placed in four groups, ten animals each, for the intraperitoneal implant of polypropylene, polypropylene/polyglecaprone, and polyester/porcine collagen meshes or suture with polyglactin (sham) after creation of defect in the abdominal wall. Twenty-one days later, histological analysis was performed after staining with hematoxylin-eosin and picrosirius red. Results The groups with meshes had a higher inflammation score (p < 0.05) and higher number of gigantocytes (p < 0.05) than the sham group, which had a better fibroplasia with a higher proportion of type I/III collagen than the tissue separating meshes (p < 0.05). There were no statistically significant differences between the three groups with meshes. Conclusions The intraperitoneal implant of polypropylene/polyglecaprone and polyester/porcine collagen meshes determined a more intense tissue inflammatory response with exuberant foreign body reaction, immature fibroplasia and low tissue proportion of type I/III collagen compared to suture with polyglactin of abdominal aponeurosis. However, there were no significant differences in relation to the polypropylene mesh group.

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Characteristics of the fibroplasia and collagen expression in the abdominal wall after implant of the polypropylene mesh and polypropylene/polyglecaprone mesh in rats

Abstract: The gain in resistance of the polypropylene mesh is regular and ascending, whereas the polypropylene/poliglecaprone is not regular. The final resistance of both meshes is similar; the collagen density increases over time, and show the same inflammatory potential.

Cited by 8 publications

References 29 publications

Textile Polypropylene Allografts and their Postoperative Tissue Reaction in the Surgery of Inguinal Hernia

Textile Polypropylene Allografts and their Postoperative Tissue Reaction in the Surgery of Inguinal Hernia

The effect of polypropylene mesh on different layers to the formation of collagen type I/ III ratio and total collagen density in incisional hernia repair

Analysis of tissue inflammatory response, fibroplasia, and foreign body reaction between the polyglactin suture of abdominal aponeurosis in rats and the intraperitoneal implant of polypropylene, polypropylene/polyglecaprone and polyester/porcine collagen meshes

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