Characteristics of the human isoplanatic patch and implications for adaptive optics retinal imaging

Bedggood, Phillip; Daaboul, Mary; Ashman, Ross A.; Smith, George; Metha, Andrew

doi:10.1117/1.2907211

Cited by 85 publications

(66 citation statements)

References 16 publications

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“…This is a process has been discussed by Grieve et al [47] It is important to align the beacon light focus on the same plane that the imaging light does, i.e., minimize the longitudinal chromatic aberration, so that the AO-SLO can produce clear photoreceptor mosaic when AO loop is closed. While the transverse chromatic aberration may cause focus of the beacon light to be displaced from the focus of the imaging, however, the transverse shift between the two beams in the human eye may be within a range of 1-2 arcminutes [47], which is much smaller than the isoplanatic zone of the human eye [48] and AO can compensate the aberration. The beacon light power was set at 15 μW for wavefront sensing.…”

Section: Extension To Ao-oct and Dual Modal Imagingmentioning

confidence: 99%

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A dual-modal retinal imaging system with adaptive optics

Meadway¹,

Girkin²,

Zhang³

2013

Opt. Express

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An adaptive optics scanning laser ophthalmoscope (AO-SLO) is adapted to provide optical coherence tomography (OCT) imaging. The AO-SLO function is unchanged. The system uses the same light source, scanning optics, and adaptive optics in both imaging modes. The result is a dual-modal system that can acquire retinal images in both en face and cross-section planes at the single cell level. A new spectral shaping method is developed to reduce the large sidelobes in the coherence profile of the OCT imaging when a non-ideal source is used with a minimal introduction of noise. The technique uses a combination of two existing digital techniques. The thickness and position of the traditionally named inner segment/outer segment junction are measured from individual photoreceptors. In-vivo images of healthy and diseased human retinas are demonstrated. 1178-1181(1991). 4. T. Wilson, Confocal Microscopy (Academic Press, 1990. 5. A. Roorda, "Applications of adaptive optics scanning laser ophthalmoscopy," Optom. Vis. Sci. 87(4), 260-268 (2010). 6. R. Yadav, K. S. Lee, J. P. Rolland, J. M. Zavislan, J. V. Aquavella, and G. Yoon, "Micrometer axial resolution OCT for corneal imaging," Biomed. Opt. Express 2(11), 3037-3046 (2011 27(1), 45-88 (2008). 62. B. Cense, N. Nassif, T. Chen, M. Pierce, S. H. Yun, B. Park, B. Bouma, G. Tearney, and J. de Boer, "Ultrahighresolution high-speed retinal imaging using spectral-domain optical coherence tomography," Opt. Express 12(11), 2435-2447 (2004).

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Section: Extension To Ao-oct and Dual Modal Imagingmentioning

confidence: 99%

“…Using a beacon light for wavefront sensing has been previously reported [47,48]. Chromatic aberration in the human eye can cause the beacon and imaging light to focus at different points, axially and transversally.…”

Section: Extension To Ao-oct and Dual Modal Imagingmentioning

confidence: 99%

A dual-modal retinal imaging system with adaptive optics

Meadway¹,

Girkin²,

Zhang³

2013

Opt. Express

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“…The main reason is a limited iso-planatic angle [78]. Within this angle aberrations introduced by the eye vary within a range that will not deteriorate the wavefront below diffraction limit.…”

Section: Field Of View and Motion Correctionmentioning

confidence: 99%

Review of adaptive optics OCT (AO-OCT): principles and applications for retinal imaging [Invited]

Pircher

Zawadzki

2017

Biomed. Opt. Express

170

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Abstract:In vivo imaging of the human retina with a resolution that allows visualization of cellular structures has proven to be essential to broaden our knowledge about the physiology of this precious and very complex neural tissue that enables the first steps in vision. Many pathologic changes originate from functional and structural alterations on a cellular scale, long before any degradation in vision can be noted. Therefore, it is important to investigate these tissues with a sufficient level of detail in order to better understand associated disease development or the effects of therapeutic intervention. Optical retinal imaging modalities rely on the optical elements of the eye itself (mainly the cornea and lens) to produce retinal images and are therefore affected by the specific arrangement of these elements and possible imperfections in curvature. Thus, aberrations are introduced to the imaging light and image quality is degraded. To compensate for these aberrations, adaptive optics (AO), a technology initially developed in astronomy, has been utilized. However, the axial sectioning provided by retinal AO-based fundus cameras and scanning laser ophthalmoscope instruments is limited to tens of micrometers because of the rather small available numerical aperture of the eye. To overcome this limitation and thus achieve much higher axial sectioning in the order of 2-5µm, AO has been combined with optical coherence tomography (OCT) into AO-OCT. This enabled for the first time in vivo volumetric retinal imaging with high isotropic resolution. This article summarizes the technical aspects of AO-OCT and provides an overview on its various implementations and some of its clinical applications. In addition, latest developments in the field, such as computational AO-OCT and wavefront sensor less AO-OCT, are covered. 1178-1181 (1991). 2. M. Wojtkowski, B. Kaluzny, and R. J. Zawadzki, "New directions in ophthalmic optical coherence tomography," Optom. Vis. Sci. 89(5), 524-542 (2012). 3. T. E. de Carlo, A. Romano, N. K. Waheed, and J. S. Duker, "A review of optical coherence tomography angiography (OCTA)," Int J Retina Vitreous 1(5), 5 (2015). 4. W. Drexler and J. G. Fujimoto, "State-of-the-art retinal optical coherence tomography," Prog. Retin. Eye Res.27(1), 45-88 (2008). 5. G. Walsh, W. N. Charman, and H. C. Howland, "Objective technique for the determination of monochromatic aberrations of the human eye," J. Opt. Soc. Am. A 1(9), 987-992 (1984). 6. J. Liang and D. R. Williams, "Aberrations and retinal image quality of the normal human eye," J. Opt. Soc. Am.A 14(11), 2873-2883 (1997). Office, 2014). 27. J. Liang, B. Grimm, S. Goelz, and J. F. Bille, "Objective measurement of wave aberrations of the human eye with the use of a Hartmann-Shack wave-front sensor," J. Opt. Soc. Am. A 11(7), 1949-1957 (1994). 28. M. Laslandes, M. Salas, C. K. Hitzenberger, and M. Pircher, "Influence of wave-front sampling in adaptive optics retinal imaging," Biomed. Opt. Express 8(2), 1083-1100 (2017). 29. S. Tuohy and A. G. Podoleanu,...

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“…Addressing this problem would require modifying the angles of incidence in the original AOSLO, which is beyond the scope of this work. Finally, even though the same number of actuators per unit area at the pupil are being used, the AO correction is expected to be poorer due to the variations of the monochromatic aberrations across the larger FOV [22].…”

Section: Resultsmentioning

confidence: 99%

First-order design of a reflective viewfinder for adaptive optics ophthalmoscopy

Dubra¹,

Sulai²

2012

Opt. Express

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Adaptive optics (AO) ophthalmoscopes with small fields of view have limited clinical utility. We propose to address this problem in reflective instruments by incorporating a viewfinder pupil relay designed by considering pupil and image centering and conjugation. Diverting light from an existing pupil optical relay to the viewfinder relay allows switching field of view size. Design methods that meet all four centering and conjugation conditions using either a single concave mirror or with two concave mirrors forming an off-axis afocal telescope are presented. Two different methods for calculating the focal length and orientation of the concave mirrors in the afocal viewfinder relay are introduced. Finally, a 2.2 × viewfinder mode is demonstrated in an AO scanning light ophthalmoscope.

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Characteristics of the human isoplanatic patch and implications for adaptive optics retinal imaging

Cited by 85 publications

References 16 publications

A dual-modal retinal imaging system with adaptive optics

A dual-modal retinal imaging system with adaptive optics

Review of adaptive optics OCT (AO-OCT): principles and applications for retinal imaging [Invited]

First-order design of a reflective viewfinder for adaptive optics ophthalmoscopy

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