Characteristics of the intestinal flora in patients with peripheral neuropathy associated with type 2 diabetes

Wang, Yayun; Ye, Xiaolong; Ding, Dafa; Lu, Yibing

doi:10.1177/0300060520936806

Cited by 49 publications

(47 citation statements)

References 27 publications

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“…Blautia and lactobacillus genera were enriched in participants with diabetes and were more abundant in the DM group than in the DR group. These increased Blautia and lactobacillus genera in diabetic patients were also observed in other studies ( Larsen et al., 2010 ; Karlsson et al., 2013 ; Wang et al., 2020 ). Wang et al.…”

Section: Discussionsupporting

confidence: 88%

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Dysbiosis and Implication of the Gut Microbiota in Diabetic Retinopathy

Huang

Wang

Ma³

et al. 2021

Front. Cell. Infect. Microbiol.

110

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The pathogenesis of type 2 diabetes mellitus (T2DM) is commonly associated with altered gut bacteria. However, whether the microbial dysbiosis that exists in human diabetic patients with or without retinopathy is different remains largely unknown. Here, we collected clinical information and fecal samples from 75 participants, including 25 diabetic patients without retinopathy (DM), 25 diabetic patients with retinopathy (DR), and 25 healthy controls (HC). The gut microbial composition in the three groups was analyzed using 16S ribosomal RNA (rRNA) gene sequencing. Microbial structure and composition differed in the three groups. The α and β diversities in both the DM and DR groups were reduced compared with those in the HC group. Blautia was the most abundant genus, especially in the DM group. In addition, increased levels of Bifidobacterium and Lactobacillus and decreased levels of Escherichia-Shigella, Faecalibacterium, Eubacterium_hallii_group and Clostridium genera were observed in the DM and DR groups compared with the HC group. Furthermore, a biomarker set of 25 bacterial families, which could distinguish patients in the DR group from those in the DM and HC groups was identified, with the area under the curve values ranging from 0.69 to 0.85. Of note, Pasteurellaceae, which was increased in DM and decreased in DR compared with HC, generated a high AUC (0.74) as an individual predictive biomarker. Moreover, 14 family biomarkers were associated with fasting blood glucose levels or diabetes, with most of them being negatively correlated. In summary, our study establishes compositional alterations of gut microbiota in DM and DR, suggesting the potential use of gut microbiota as a non-invasive biomarker for clinical and differential diagnosis, as well as identifying potential therapeutic targets of diabetic retinopathy.

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Section: Discussionsupporting

confidence: 88%

“…These increased Blautia and lactobacillus genera in diabetic patients were also observed in other studies ( Larsen et al., 2010 ; Karlsson et al., 2013 ; Wang et al., 2020 ). Wang et al. (2020) reported that Blautia was positively correlated with tauroursodeoxycholic acid (TUDCA) levels.…”

Section: Discussionsupporting

confidence: 88%

Dysbiosis and Implication of the Gut Microbiota in Diabetic Retinopathy

Huang

Wang

Ma³

et al. 2021

Front. Cell. Infect. Microbiol.

110

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“…Finally, we examined the lipid metabolism of the three major species of Lachnoclostridium as we found a positive association with visceral fat, as well as several studies have reported it to be related to diet-induced obesity (Zhao L. et al, 2017;Li et al, 2019;Sun et al, 2020), total cholesterol and LDL-C (Wang et al, 2020). Additionally, the mechanisms by through Lachnoclostridium impacts obesity remain unknown.…”

Section: Discussionmentioning

confidence: 78%

Circulating Levels of the Short-Chain Fatty Acid Acetate Mediate the Effect of the Gut Microbiome on Visceral Fat

et al. 2021

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BackgroundAcetate is a short-chain fatty acid (SCFA) produced by gut bacteria, which has been implicated in cardio-metabolic health. Here we examine the relationships of circulating acetate levels with gut microbiome composition and diversity and with visceral fat in a large population-based cohort.ResultsMicrobiome alpha-diversity was positively correlated with circulating acetate levels (Shannon, Beta [95%CI] = 0.12 [0.06, 0.18], P = 0.002) after adjustment for covariates. Six serum acetate-associated bacterial genera were also identified, including positive correlations with Coprococcus, Barnesiella, Ruminococcus, and Ruminococcaceae NK4A21 and negative correlations were observed with Lachnoclostridium and Bacteroides. We also identified a correlation between visceral fat and serum acetate levels (Beta [95%CI] = −0.07 [−0.11, −0.04], P = 2.8 × 10–4) and between visceral fat and Lachnoclostridium (Beta [95%CI] = 0.076 [0.042, 0.11], P = 1.44 × 10–5). Formal mediation analysis revealed that acetate mediates ∼10% of the total effect of Lachnoclostridium on visceral fat. The taxonomic diversity showed that Lachnoclostridium and Coprococcus comprise at least 18 and 9 species, respectively, including novel bacterial species. By predicting the functional capabilities, we found that Coprococcus spp. present pathways involved in acetate production and metabolism of vitamins B, whereas we identified pathways related to the biosynthesis of trimethylamine (TMA) and CDP-diacylglycerol in Lachnoclostridium spp.ConclusionsOur data indicates that gut microbiota composition and diversity may influence circulating acetate levels and that acetate might exert benefits on certain cardio-metabolic disease risk by decreasing visceral fat. Coprococcus may play an important role in host health by its production of vitamins B and SCFAs, whereas Lachnoclostridium might have an opposing effect by influencing negatively the circulating levels of acetate and being involved in the biosynthesis of detrimental lipid compounds.

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“…Diabetic neuropathy has been linked to changes in the diversity of the gut microbiota and the increased presence of pathogens [ 81 ]. A comparison of the gut microbiota in patients with diabetic neuropathy, patients with diabetes without diabetic neuropathy and healthy individuals showed an increase in Firmicutes and Actinobacteria as well as a decrease in Bacteroidetes in patients with diabetic nephropathy when compared to patients with diabetes without diabetic neuropathy and healthy individuals.…”

Section: Gut Microbiota Type 2 Diabetes and Its Complicationsmentioning

confidence: 99%

Gut Microbiota and Complications of Type-2 Diabetes

2021

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The gut microbiota has been linked to the emergence of obesity, metabolic syndrome and the onset of type 2 diabetes through decreased glucose tolerance and insulin resistance. Uncontrolled diabetes can lead to serious health consequences such as impaired kidney function, blindness, stroke, myocardial infarction and lower limb amputation. Despite a variety of treatments currently available, cases of diabetes and resulting complications are on the rise. One promising new approach to diabetes focuses on modulating the gut microbiota with probiotics, prebiotics, synbiotics and fecal microbial transplantation. Differences in gut microbiota composition have been observed in preclinical animal models as well as patients with type 2 diabetes and complications such as diabetic nephropathy, diabetic retinopathy, diabetic neuropathy, cerebrovascular disease, coronary heart disease and peripheral artery disease compared to healthy controls. Severity of gut microbiota dysbiosis was associated with disease severity and restoration with probiotic administration in animal models and human patients has been associated with improvement of symptoms and disease progression. Characterizing the gut microbiota dysbiosis in different diseases and determining a causal relationship between the gut microbiota and disease can be beneficial in formulating therapeutic interventions for type 2 diabetes and associated complications. In this review, we present the most important findings regarding the role of the gut microbiota in type 2 diabetes and chronic complications as well as their underlying mechanisms.

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Characteristics of the intestinal flora in patients with peripheral neuropathy associated with type 2 diabetes

Cited by 49 publications

References 27 publications

Dysbiosis and Implication of the Gut Microbiota in Diabetic Retinopathy

Dysbiosis and Implication of the Gut Microbiota in Diabetic Retinopathy

Circulating Levels of the Short-Chain Fatty Acid Acetate Mediate the Effect of the Gut Microbiome on Visceral Fat

Gut Microbiota and Complications of Type-2 Diabetes

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