Characteristics of traditional Chinese medicine syndromes in post-stroke depression

Han, Hui; Wu, Limin; Yang, Weidong; Wang, Meixia; Tang, Jingjing; Wang, Han; Liu, Zhixiu; Liu, Rongzhi; Dong, Tingting; Zhang, Juan; Yang, Bo; Han, Ming-xiang

doi:10.3736/jcim20100505

Cited by 15 publications

(8 citation statements)

References 10 publications

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“…It has been regarded as “depression syndrome” and “liver qi stagnation” in TCM. [242526] CHSGS consists of seven crude herbal drugs and is used to treat depression-related syndromes associated with qi stagnation. Qi stagnation has been categorized as a term in TCM that refers to insidious, long-standing, serious discomfort that is projected into the body and is manifested by numerous symptoms, such as insomnia, fatigue, panic, and dyspnea.…”

Section: Discussionmentioning

confidence: 99%

Antidepressant-like effects of Chaihu-Shugan-San via SAPK/JNK signal transduction in rat models of depression

Zhang

Qiu

et al. 2014

Phcog Mag

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Background:Chaihu-Shugan-San (CHSGS), a traditional Chinese medicinal herbal formula, registered in Jingyue Quanshu, has been indicated that oral administration of the extract from it can remit depressive disorder. C-Jun amino-terminal kinase (JNK/SAPK) signal transduction plays a key role in the apoptosis of nerve cells, be reported closely correlated with depression. This study was designed to investigate CHSGS antidepressant-like effects in rat models of depression and probe its possible mechanism.Materials and Methods:The classical experimental depression model chronic mild unpredictable stress (CMUS) was used to evaluate the antidepressant-like effects of CHSGS. The extracts were administered orally for 14 days, while the parallel positive control was given at the same time using fluoxetine hydrochloride. The expressions of JNK in the hippocampus were detected by real-time fluorescent quantitation PCR and Western blot assay.Results:Intragastric administration of CHSGS for 14 days caused a significant improvement of weight and locomotor activity in the open-field test. In addition, CHSGS treatment inhibited the expressions of JNK in the hippocampus tissue in CMUS rats.Conclusion:CHSGS could obviously improve the depressive state of the model rats and its mechanism may be correlated with regulating the expressions of JNK in the hippocampus.

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Section: Discussionmentioning

confidence: 99%

Antidepressant-like effects of Chaihu-Shugan-San via SAPK/JNK signal transduction in rat models of depression

Zhang

Qiu

et al. 2014

Phcog Mag

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“…From the point of view of TCM the main syndromes of depression are qi stagnation and blood stasis, liver qi depression and transformation of fire due to qi stagnation [13]. In China, there are several pre-clinical and clinical studies using Chinese herbal medicine which are the basis for design of new therapeutic programmes for treatment of depression [13]. In addition, acupuncture is also used in several evidence- based studies concerning this topic of research.…”

Section: Discussionmentioning

confidence: 99%

Clinical Teleacupuncture between China and Austria Using Heart Rate Variability in Patients with Depression

Wang¹,

Gan²,

Sheng³

et al. 2011

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In previous studies by the same research group it has been shown in post-stroke patients that the autonomic system can be affected by acupuncture. Within this study, teleacupuncture between China and Austria is used for quantifying the effects of heart rate variability (HRV) in Chinese patients suffering from depression. In 22 Chinese depression patients (17 f, 5 m; mean age ± SD 52.3 ± 10.6 years; range 31 - 70 years) electrocardiographic signals before, during and after acupuncture at the acupoint Jianshi (PC 5) were recorded in Harbin and analyzed in Graz using teleacupuncture via internet. HRV data were analyzed in the time and frequency domain and a protocol from Austria was sent to the team in China immediately after the treatment and recording session. Mean heart rate decreased significantly (p < 0.001) during and after acupuncture, whereas total HRV increased significantly during (p < 0.034) and after (p < 0.001) acupuncture, always immediately following manual needle stimulation. Furthermore, there is a marked decrease in balance between sympathetic and parasympathetic activity (low frequency/high frequency HRV ratio) during treatment. This study shows that HRV could be a useful parameter for quantifying clinical effects of acupuncture on the autonomic nervous system. Teleacupuncture between China and Austria over a distance of more than 8,500 km has been successfully used

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“…New-generation antidepressants appear more effective than older drugs; however, many drugs have side effects that can affect compliance and morbidity [1]. From the point of view of TCM the main syndromes of depression are qi stagnation, and blood stasis, liver qi depression and transformation of fire due to qi stagnation [15]. In China, there are several preclinical and clinical studies using Chinese herbal medicine, which are the basis for design of new therapeutic programmes for treatment of depression [15].…”

Section: Discussionmentioning

confidence: 99%

“…From the point of view of TCM the main syndromes of depression are qi stagnation, and blood stasis, liver qi depression and transformation of fire due to qi stagnation [15]. In China, there are several preclinical and clinical studies using Chinese herbal medicine, which are the basis for design of new therapeutic programmes for treatment of depression [15]. In addition, acupuncture is also used in several evidence-based studies concerning this topic of research.…”

Section: Discussionmentioning

confidence: 99%

Biomedical Teleacupuncture between China and Austria Using Heart Rate Variability—Part 2: Patients with Depression

Litscher

Gan

Wang

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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It has been shown in previous studies that the autonomic nervous system can be affected by acupuncture. Within this study, teleacupuncture between China and Austria is used for quantifying the effects of heart rate (HR) and heart rate variability (HRV) in 33 Chinese patients (27 females, 6 males; mean age ± SD 49.5 ± 13.1 years; range 22–72 years) suffering from depression. Electrocardiographic signals before, during, and after acupuncture at the acupoint Baihui (GV20) were recorded in Harbin and analyzed in Graz using teleacupuncture. HRV data were analyzed in the time and frequency domain. Mean HR decreased significantly (P < 0.05) during and after acupuncture, whereas total HRV increased significantly after the third acupuncture stimulation period (P < 0.05) and also 5–10 minutes after (P < 0.05) acupuncture. The study shows that HRV could be a useful parameter for quantifying clinical effects of acupuncture on the autonomic nervous system.

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Characteristics of traditional Chinese medicine syndromes in post-stroke depression

Cited by 15 publications

References 10 publications

Antidepressant-like effects of Chaihu-Shugan-San via SAPK/JNK signal transduction in rat models of depression

Antidepressant-like effects of Chaihu-Shugan-San via SAPK/JNK signal transduction in rat models of depression

Clinical Teleacupuncture between China and Austria Using Heart Rate Variability in Patients with Depression

Biomedical Teleacupuncture between China and Austria Using Heart Rate Variability—Part 2: Patients with Depression

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