Characteristics of users of online personalized genomic risk assessments: Implications for physician-patient interactions

McBride, Colleen M.; Alford, Sharon Hensley; Reid, Robert J.; Larson, Eric B.; Baxevanis, Andreas D.; Brody, Lawrence C.

doi:10.1097/gim.0b013e3181b22c3a

Cited by 104 publications

(158 citation statements)

References 23 publications

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“…A one-item question about familiarity, "how familiar are you with your family's health history? ", "not at all familiar (1)" to "very familiar (5)," was adapted from a previous study (McBride et al 2009) and used as a proxy for participants' knowledge (behavioral capability).…”

Section: Extent Of Fhh Communicationmentioning

confidence: 99%

Family health information sharing among older adults: reaching more family members

Ashida

Schafer

2014

J Community Genet

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Although family health history (FHH) information has tremendous potential in the prevention of common complex diseases such as heart disease and cancer, lack of knowledge about one's own FHH among the public hinders its utility. Older individuals often desire to contribute to the well-being of younger generations and also play critical roles in disseminating this information. This study evaluated psychosocial factors associated with the extent of FHH communication within families. Older adults (N = 110) were interviewed at three senior centers in an urban community. Multivariate Poisson regression analysis showed that respondents who received FHH from a parent reported 41 % more family members with whom they shared FHH (b=0.34, p < 0.001) controlling for the family network size. Furthermore, one unit increase in the number of family members with whom respondents exchange reciprocal emotional support (b=0.04, p<0.01), perceived familiarity with own FHH (b=0.14, p=0.01), and self-efficacy to share FHH (b= 0.18, p=0.02) were associated with 4, 15, and 20 % increases in the number of family members with whom respondents shared FHH, respectively. Future efforts may inform older adults about their important role in modeling FHH communication behavior to encourage information sharing in future generations while providing information about how to collect and disseminate FHH to increase their familiarity and ability to share FHH within the family.

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Section: Extent Of Fhh Communicationmentioning

confidence: 99%

Family health information sharing among older adults: reaching more family members

Ashida

Schafer

2014

J Community Genet

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“…It is possible that the offer of genetic susceptibility testing for common chronic disease risk did not represent new or particularly novel information to the Multiplex participants. Although study participants had no prior diagnosis with diabetes mellitus, atherosclerotic cardiovascular disease, osteoporosis, or cancer, there was a relatively high prevalence of behavioral risk factors including cigarette smoking, physical inactivity, and obesity [37]. Moreover, these individuals reported high levels of awareness of behavioral risk factors associated with the diseases included on the multiplex test [37].…”

Section: Discussionmentioning

confidence: 99%

“…Although study participants had no prior diagnosis with diabetes mellitus, atherosclerotic cardiovascular disease, osteoporosis, or cancer, there was a relatively high prevalence of behavioral risk factors including cigarette smoking, physical inactivity, and obesity [37]. Moreover, these individuals reported high levels of awareness of behavioral risk factors associated with the diseases included on the multiplex test [37]. Also, it is worth considering that some participants may have had other chronic diseases not represented in the exclusion criteria, but which are associated with an elevated risk for one or more of the multiplex diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Lastly, a variable was included that measured the extent that respondents attributed common diseases, on average, to genetics versus behavior. This variable was derived from a series of items that asked respondents to report how much they believed that health habits and genetics determine a person's risk for developing each of the eight diseases [37]. A summary score across all eight health conditions was calculated (M=0.42, SD=0.11).…”

Section: Methodsmentioning

confidence: 99%

“…And (3) does perceived disease susceptibility, severity, and worry mediate the association of those individual difference characteristics with seeking information about genetic testing? METHOD Data were collected as part of the Multiplex Initiative which is described in detail elsewhere [6,36,37]. Briefly, the overarching aim of the Multiplex Initiative was to evaluate uptake of genetic susceptibility testing as a primary prevention strategy, specifically serving as a cue to take preventive actions including seeking health information.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Exploring dispositional tendencies to seek online information about direct-to-consumer genetic testing

Paquin

Richards

Koehly

et al. 2012

Behav. Med. Pract. Policy Res.

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Varying perspectives exist regarding the implications of genetic susceptibility testing for common disease, with some anticipating adverse effects and others expecting positive outcomes; however, little is known about the characteristics of people who are most likely to be interested in direct-to-consumer genetic testing. To that end, this study examines the association of individual dispositional differences with health risk perceptions and online information seeking related to a free genetic susceptibility test. Healthy adults enrolled in a large health maintenance organization were surveyed by telephone. Eligible participants (N=1,959) were given access to a secure website that provided risk and benefit information about a genetic susceptibility test and given the option to be tested. Neuroticism was associated with increased perceptions of disease risk but not with logging on. Those scoring high in conscientiousness were more likely to log on. We found no evidence that neuroticism, a dispositional characteristic commonly linked to adverse emotional response, was predictive of online genetic information seeking in this sample of healthy adults.

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Interest and Uptake ofMC1RTesting for Melanoma Risk in a Diverse Primary Care Population

et al. 2018

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Importance Germline variants in the MC1R gene are common and confer moderate melanoma risk in those with varied skin types. Approaches to precision skin cancer prevention that include genetic information may promote risk awareness and risk reduction in the general population, including Hispanics. Objective To examine prevalence of interest in and uptake of MC1R testing in the general population and examine patterns across demographic and skin cancer risk factors. Design A randomized controlled trial examined interest in and uptake of MC1R testing. Study participants were randomized to either a usual care condition (NCI skin cancer pamphlet for diverse skin types) or an MC1R test offer. Setting University of New Mexico General Internal Medicine clinics. Participants Participants were registered clinic patients (≥ 6 months) and English or Spanish fluent. Of the N=600 recruited to the overall trial, the current study included those 499 participants randomized to the MC1R test offer (44% non-Hispanic white, 49% Hispanic, 79% female; mean age=54). Intervention Participants were presented with the option to log onto the study website to read three educational modules presenting the rationale, benefits and drawbacks of MC1R testing. Main Outcomes and Measures Main outcomes include website logon (yes vs. no), saliva test kit request (yes vs. no), and saliva test kit return for MC1R testing (yes vs. no). Demographic and skin cancer risk factors were examined as potential predictors of test interest and uptake. Results About half of participants (46%, n=232) elected to learn about MC1R testing by logging onto the website; most that logged on decided to request testing (88%, n=204); and most who requested testing returned the kit (82%, n=167). The strongest predictors of website logon were race/ethnicity and education (non-Hispanic whites and more highly educated were more likely to log on); the strongest predictor of ordering the test was sunburn history. Conclusion and Relevance There were moderately high levels of MC1R test interest and uptake in this diverse sample. Addressing potential barriers to testing may be warranted as genomic information becomes integrated into general population approaches to the precision prevention of skin cancer.

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Characteristics of users of online personalized genomic risk assessments: Implications for physician-patient interactions

Cited by 104 publications

References 23 publications

Family health information sharing among older adults: reaching more family members

Family health information sharing among older adults: reaching more family members

Exploring dispositional tendencies to seek online information about direct-to-consumer genetic testing

Interest and Uptake ofMC1RTesting for Melanoma Risk in a Diverse Primary Care Population

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