Characteristics of vagal reflex-mediated tracheal response induced by bronchoconstriction in guinea pigs

Takahashi, Yūzō; Ohno, Hiromitsu; Misawa, Miwa

doi:10.1016/0014-2999(96)00017-9

European Journal of Pharmacology

1996

DOI: 10.1016/0014-2999(96)00017-9

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Characteristics of vagal reflex-mediated tracheal response induced by bronchoconstriction in guinea pigs

Yūzō Takahashi¹,

Hiromitsu Ohno²,

Miwa Misawa

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1997

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Cited by 2 publications

(1 citation statement)

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“…NEURONAL NO AND AIRWAY RESPONSIVENESS iNANC-mediated reflex tracheal dilatation in guinea pigs (28). Thus our result seems inconsistent with those previous observations.…”

contrasting

confidence: 99%

Nitric oxide derived from sympathetic nerves regulates airway responsiveness to histamine in guinea pigs

Matsumoto

Aizawa

Takata

et al. 1997

Journal of Applied Physiology

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Nitric oxide (NO), which can be derived from the nervous system or the epithelium of the airway, may modulate airway responsiveness. We investigated how NO derived from the airway nervous system would affect the airway responsiveness to histamine and acetylcholine in mechanically ventilated guinea pigs. An NO synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME) (1 mmol/kg i.p.) significantly enhanced airway responsiveness to histamine but not to acetylcholine. Its enantiomer D-NAME (1 mmol/kg i.p.), in contrast, had no effect. The L-NAME-induced airway hyperresponsiveness was still observed in animals pretreated with propranolol (1 mg/kg i.v.) and atropine (1 mg/kg i.v.). Pretreatment with the ganglionic blocker hexamethonium (2 mg/kg i.v.) completely abolished enhancing effect of L-NAME on airway responsiveness. Bilateral cervical vagotomy did not alter the L-NAME-induced airway hyperresponsiveness, whereas sympathetic stellatectomy completely abolished it. Results suggest that NO that was presumably derived from the sympathetic nervous system regulates airway responsiveness to histamine in guinea pigs.

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“…NEURONAL NO AND AIRWAY RESPONSIVENESS iNANC-mediated reflex tracheal dilatation in guinea pigs (28). Thus our result seems inconsistent with those previous observations.…”

contrasting

confidence: 99%

Nitric oxide derived from sympathetic nerves regulates airway responsiveness to histamine in guinea pigs

Matsumoto

Aizawa

Takata

et al. 1997

Journal of Applied Physiology

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Neural reflex-mediated tracheal response during bronchoconstriction induced by ovalbumin antigen in guinea pigs

Takahashi

Mizuno

Ohno

et al. 1997

General Pharmacology: The Vascular System

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Characteristics of vagal reflex-mediated tracheal response induced by bronchoconstriction in guinea pigs

Cited by 2 publications

References 36 publications

Nitric oxide derived from sympathetic nerves regulates airway responsiveness to histamine in guinea pigs

Nitric oxide derived from sympathetic nerves regulates airway responsiveness to histamine in guinea pigs

Neural reflex-mediated tracheal response during bronchoconstriction induced by ovalbumin antigen in guinea pigs

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