Characteristics, prevalence, risk factors, and underlying mechanism of hyponatremia in elderly patients treated with antidepressants: A cross-sectional study

Mannesse, C. K.; Jansen, Paul A. F.; Marum, Rob J. van; Sival, Rob C.; Kok, Rob M.; Haffmans, P.M.J.; Egberts, Toine C. G.

doi:10.1016/j.maturitas.2013.08.010

Cited by 52 publications

(61 citation statements)

References 25 publications

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“…According to other studies, antidepressants not only increase the secretion of ADH, but also increase the sensitivity of the kidneys to this hormone [31].…”

Section: Siadh and Antidepressantsmentioning

confidence: 88%

“…In a study by Mannesse et al, the incidence of hyponatremia was slightly higher among patients taking TLPDs than with other antidepressants, but this difference was not statistically significant [31]. There are also reports of hyponatraemia associated with duloxetine use [36].…”

Section: Siadh and Antidepressantsmentioning

confidence: 96%

“…Giorlando et al, in a retrospective study from 2013, found that risk factors for hyponatremia following SSRI and SNRI were age > 65 years, female sex and sertraline or escitalopram use [37]. Other risk factors for hyponatremia include past events of hyponatremia in the patient, body weight <60 kg, psychotic symptoms [31], female sex [25] and antidepressant combination with diuretics, angiotensin converting enzyme inhibitors (ACEI) or inhibitors of protonic pump (IPP) [34].…”

Section: Siadh and Antidepressantsmentioning

confidence: 99%

“…udowodnili, że serotonina stymuluje sekrecję ADH za pośrednictwem receptorów 5HT2c, 5HT2a i 5HT7 [30]. Wg innych badań leki przeciwdepresyjne nie tylko powodują wzrost wydzielania ADH, ale także wzmożoną wrażliwość nerek na ten hormon [31].…”

Section: Przyczynyunclassified

“…W badaniu przeprowadzonym przez Mannesse i wsp. częstość występowania hiponatremii była nieco wyższa wśród pacjentów stosujących TLPD, niż pozostałych leków przeciwdepresyjnych, ale różnica ta nie była istotna statystycznie [31]. Istnieją również doniesienia o występowaniu hiponatremii po zastosowaniu duloksetyny [36].…”

Section: Przyczynyunclassified

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Hiponatremia in the practice of a psychiatrist. Part 1: SIADH syndrome and drug-induced hyponatremia.

Stelmach

Hołownia

Słotwiński

et al. 2017

Current Problems of Psychiatry

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Introduction. Hyponatremia is an important part of psychiatric practice. In order to analyze its causes and symptoms, the literature on hyponatremia in psychiatric patients has been reviewed. The work has been divided into two separate manuscripts. In the first one the authors discuss the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and hyponatremia occurring with the use of psychotropic drugs (antidepressants, antipsychotics, normotimics), while the second paper discusses research on psychogenic polydipsia. The causes of hyponatremia in patients treated in psychiatric wards include: water intoxication associated with polydipsia, somatic comorbidities, side effect of internal medicine and psychiatric drugs. The most common mechanism leading in these cases to hyponatremia is the syndrome of inappropriate secretion of vasopressin (SIADH). The SIADH syndrome is a group of symptoms, first described in 1967 by Schwartz and Bartter in The American Journal of Medicine, which results from the hypersecretion of antidiuretic hormone, also called vasopressin, which causes patients to develop normovolemic hyponatremia. The phenomenon of drug-induced hyponatremia in psychiatric practice is generally observed with the use of antidepressants, antipsychotics and anti-epileptic drugs (used in psychiatry as normotimic drugs).Aim and method. The first manuscript includes a review of literature on the syndrome of inappropriate secretion of vasopressin (SIADH) and hyponatremia occurring after the use of psychotropic drugs, and is divided into two subsections: 1. The syndrome of inappropriate secretion of vasopressin (SIADH), 2. Hyponatremia and psychotropic drugs (antidepressants, antipsychotics, normotimics).Conclusion. In the view of the reviewed literature it is extremely important to control the natremia level during pharmacotherapy using the above mentioned drugs, especially in the initial period of therapy.

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“…According to other studies, antidepressants not only increase the secretion of ADH, but also increase the sensitivity of the kidneys to this hormone [31].…”

Section: Siadh and Antidepressantsmentioning

confidence: 88%

Section: Siadh and Antidepressantsmentioning

confidence: 96%

Section: Siadh and Antidepressantsmentioning

confidence: 99%

Section: Przyczynyunclassified

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Hiponatremia in the practice of a psychiatrist. Part 1: SIADH syndrome and drug-induced hyponatremia.

Stelmach

Hołownia

Słotwiński

et al. 2017

Current Problems of Psychiatry

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Depression and Anxiety Disorders

2021

The Maudsley Prescribing Guidelines in Psychiatry

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Depression is widely recognised as a major public health problem around the world. The basic principles of prescribing are described in this chapter, along with a summary of NICE guidance. This chapter concentrates on the use of antidepressants and offers advice on drug choice, dosing, switching strategies and sequencing of treatments. Management of treatment‐resistant depression has been informed by the STAR*D programme. The 2019 PANDA trial results support the prescription of selective serotonin reuptake inhibitor antidepressants in a wider group of participants than previously thought, including those with mild to moderate symptoms who do not meet diagnostic criteria for depression or generalised anxiety disorder. Over the last two decades, ketamine, an uncompetitive N‐Methyl‐D‐Aspartate receptor antagonist and dissociative anaesthetic, has emerged as a novel and effective rapid‐acting antidepressant. Psychotic depression is an under‐identified disorder and may have a life‐time risk of up to 1%.

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Hyponatremia‐induced generalized seizure after taking polyethylene glycol for colon preparation—A case report and brief review of the literature

Seirafian

Sebghatollahi

Bastani

2022

Clinical Case Reports

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Characteristics, prevalence, risk factors, and underlying mechanism of hyponatremia in elderly patients treated with antidepressants: A cross-sectional study

Cited by 52 publications

References 25 publications

Hiponatremia in the practice of a psychiatrist. Part 1: SIADH syndrome and drug-induced hyponatremia.

Hiponatremia in the practice of a psychiatrist. Part 1: SIADH syndrome and drug-induced hyponatremia.

Depression and Anxiety Disorders

Hyponatremia‐induced generalized seizure after taking polyethylene glycol for colon preparation—A case report and brief review of the literature

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