Characteristics, staging and outcomes of differentiated thyroid cancer in patients with and without Graves’ disease

Gopinath, Chaitra; Crow, Hanna; Panthi, Sujata; Bantis, Leonidas E.; Burman, Kenneth D.; Choudhary, Chitra

doi:10.1016/j.jcte.2023.100321

Cited by 1 publication

(1 citation statement)

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“…Well-differentiated cancer of the thyroid gland is one of the most common types of endocrine neoplasias, representing the ninth most frequent malignancy worldwide [1]. During the last decades, its incidence has increased approximately by 300%, affecting a wide spectrum of patients, including adolescents and young adults, while the female-to-male ratio is estimated to be 1:2 [2,3]. Despite its increasing prevalence, the prognosis of thyroid cancer is rather good, with an estimated five-year survival rate ranging between 80% and 90% in European countries [4].…”

Section: Introductionmentioning

confidence: 99%

Quality of Life in Patients With Well-Differentiated Thyroid Carcinoma After Total Thyroidectomy in Greece

Agglopoulou,

Gkrinia,

Bizaki-Vallaskangas

et al. 2024

Cureus

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Introduction: Well-differentiated thyroid cancer is among the most common types of endocrine cancer. Despite its increasing prevalence, the prognosis of thyroid cancer is rather good, with a five-year survival rate ranging between 80% and 90%, depending on the histological type. Not only the post-treatment complications and the side effects of the lifelong medication but also the possibility of a recurrence may have a negative impact on the patient's quality of life (QoL).Objective: The aim of this study is to investigate the impact of total thyroidectomy on the QoL of patients with well-differentiated thyroid carcinoma.Methods: A prospective study was performed in patients who underwent total thyroidectomy due to welldifferentiated thyroid carcinoma in the Otolaryngology-Head and Neck Surgery Department at the University Hospital of Larissa, Greece. The QoL was evaluated based on the "Quality of Life (Thyroid Version)" questionnaire.Results: One hundred patients participated in the study, with a mean age of 51.24±15.33 years. Of these, 63 (63%) were females and 37 (37%) were males. Social concerns, physical well-being, and psychological wellbeing presented a gradual positive alteration during the first 12 months after the surgery, with psychological well-being reporting the most significant progress of 15.3%. However, spiritual well-being appeared to decline over time. The younger patients progressively improved their physical, psychological, and mental well-being; however, the older patients showed an amelioration of their social skills. Female patients reported higher levels of spiritual well-being, whereas males developed better social skills.Conclusions: In the long term, total thyroidectomy can ameliorate patients' physical status, psychological well-being, and social concerns. However, it might have a negative effect on their mental health during the first 12 months postoperatively. In addition, QoL is directly influenced by demographic characteristics such as age and gender.

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