Characteristics, treatment trends, and long-term outcomes of Japanese patients with pregnancy-associated breast cancer (PABC)

Kataoka, Akemi; Ueno, Takayuki; Yamauchi, Hideko; Uehiro, Natsue; Takahata, Chikako; Takahashi, Yōko; Nakashima, Eri; Ogiya, Akiko; Sakai, Takehiko; Kitagawa, Dai; Morizono, Hidetomo; Miyagi, Yohei; Iwase, Takuji; Kitano, Atsuko; Fukatsu, Yumi; Tamura, Nobuko; Kawano, Junko; Bando, Hiroko; Tamaki, Kentaro; Shiota, Kyoko; Ozawa, Miwa; Kobayashi, Mariko; Ohno, Shinji

doi:10.1007/s12282-022-01362-0

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…Moreover, PPBC has a poorer prognosis compared to that of PABC [15,17]. A recent Japanese cohort study has shown that patients with PPBC have signi cantly lower BC-DFS and OS rates than those in patients with PrBC [10]. However, the pathogenesis and genomic pro les of PABC remain unclear [11].…”

Section: Discussionmentioning

confidence: 99%

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Breast cancer occurring during pregnancy of Luminal A type overexpressed CXCL13

Nozaki

Nakanishi

Tanino

et al. 2023

Preprint

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Background Breast cancer during pregnancy and lactation occurs in 2.6% of female patients aged < 45 years, and its incidence has been increasing. The pathogenesis and genomic profiles of pregnancy-associated breast cancer (PABC) remain unclear. We analyzed patients with breast cancer that occurred during pregnancy (PrBC) and compared the findings with those of patients with breast cancer that did not occur during pregnancy (non-PrBC). Methods We performed gene expression analyses (using microarray and qRT-PCR) of PrBC (8 and 22 samples, respectively) and non-PrBC (8 and 24 samples, respectively) groups, which were matched for age, hormone receptor expression, and HER2 expression. Results Microarray analysis showed that 355 genes were upregulated and 151 genes were downregulated in the luminal type PrBC group compared to those in the non-PrBC group. Chemokine, C-X-C motif chemokine ligand 13 (CXCL13) gene was the most upregulated in the PrBC group compared to that in the non-PrBC group (log2 fold-change = 101.2), especially in the luminal A-type cells (p = 0.016). This result was corroborated by the qRT-PCR analysis of microdissected cancer cells, which was conducted using formalin-fixed paraffin-embedded (FFPE) samples (p < 0.001). A negative correlation was observed between CXCL13 and estrogen receptor 1 (ESR1) mRNA expression levels in luminal A-type breast carcinoma (τ = -0.109; p < 0.001). Conclusion CXCL13, a chemokine that regulates the function of immune cells, was significantly overexpressed in PrBC cells. The expression levels of CXCL13 and estrogen receptor (ER) were inversely correlated.

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Section: Discussionmentioning

confidence: 99%

“…Kataoka reported that patients with breast cancer diagnosed within one year of childbirth or during lactation (LBC) had signi cantly lower breast cancer-speci c disease-free survival (BC-DFS) and OS than those in patients with PrBC [10]. Few genomic studies on PABC have been conducted [11], and its molecular characteristics remain unknown.…”

Section: Introductionmentioning

confidence: 99%

Breast cancer occurring during pregnancy of Luminal A type overexpressed CXCL13

Nozaki

Nakanishi

Tanino

et al. 2023

Preprint

Self Cite

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“…Some authors suggest that distinguishing between breast cancer diagnosed during pregnancy and postpartum/lactation could improve the characterization of disease biology and prognosis [9]. In fact, PABC and post-partum BC might present different clinical characteristics [10], and data on prognosis are still highly controversial [11,12]. Lastly, one study focused on differences among PABC diagnosed in different trimesters of gestation, and found better clinicopathological characteristics and prognosis in first-trimester PABC [13].…”

Section: Introductionmentioning

confidence: 99%

Impact of Pregnancy on Breast Cancer Features and Prognosis

Bounous,

Minella,

Fuso

et al. 2024

Current Oncology

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Background: pregnancy-associated breast cancer (PABC) affects one in 3000 pregnancies, often presenting with aggressive features. Methods: We retrospectively evaluated a cohort of 282 young BC patients (≤45 years old) treated between 1995 and 2019, dividing them into three groups: nulliparous women, women with PABC (diagnosed within 2 years since last pregnancy) and women with BC diagnosed > 2 years since last pregnancy. This last group was further stratified according to the time between pregnancy and BC. The analysis encompassed histological factors (tumor size, histotype, grading, nodal involvement, multifocality, lympho-vascular invasion, hormone receptor expression, Ki-67 index, and HER2 expression), type of surgery and recurrence. Results: Age at diagnosis was younger in nulliparous than in parous women (p < 0.001). No significant differences were noticed regarding histological characteristics and recurrences. At univariate analysis, nodal involvement (OR = 2.4; p < 0.0001), high tumor grade (OR = 2.6; p = 0.01), and lympho-vascular invasion (OR = 2.3; p < 0.05), but not pregnancy (OR = 0.8; p = 0.30), influenced DFS negatively. Multivariate analysis confirmed nodal involvement as the only negative independent prognostic factor for a worse DFS (OR = 2.4; p = 0.0001). Conclusions: in our experience, pregnancy is not an independent adverse prognostic factor for BC DFS.

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Breast cancer during pregnancy of Luminal A type overexpressed CXCL13

Nozaki,

Nakanishi,

Tanino

et al. 2024

Pathology International

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Pregnancy‐associated breast cancer has been increasing. In this study, we analyzed patients with breast cancer that occurred during pregnancy (PrBC) and compared their genetic profiles with those of patients with breast cancer that did not occur during pregnancy, within 1 year after childbirth nor during lactation (non‐PrBC). We performed gene expression analyses of patients with PrBC and non‐PrBC using microarrays and qRT‐PCR. Microarray analysis showed that 355 genes were upregulated in the luminal‐type PrBC group compared to those in the non‐PrBC group. The C‐X‐C motif chemokine ligand 13 (CXCL13) gene was the most upregulated in the PrBC group compared to that in the non‐PrBC group, especially in the luminal A‐type (p = 0.016). This result was corroborated by the qRT‐PCR analysis of microdissected cancer cells (p < 0.001). A negative correlation was observed between CXCL13 and estrogen receptor 1 (ESR1) mRNA expression levels in luminal A‐type breast carcinoma (p < 0.001). Our results provide clues for a better understanding of breast cancer pathogenesis during pregnancy.

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Characteristics, treatment trends, and long-term outcomes of Japanese patients with pregnancy-associated breast cancer (PABC)

Cited by 4 publications

References 20 publications

Breast cancer occurring during pregnancy of Luminal A type overexpressed CXCL13

Breast cancer occurring during pregnancy of Luminal A type overexpressed CXCL13

Impact of Pregnancy on Breast Cancer Features and Prognosis

Breast cancer during pregnancy of Luminal A type overexpressed CXCL13

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