Characterization and antibacterial activity of amoxicillin-loaded electrospun nano-hydroxyapatite/poly(lactic-co-glycolic acid) composite nanofibers

Antitumor activity of electrospun polylactide nanofibers loaded with 5-fluorouracil and oxaliplatin against colorectal cancer

“…The majority of these devices are biodegradable so as to circumvent a second surgery for device removal and to avoid a chronic foreign body immune response (Langer, 1980;Kim et al, 2009b;De Souza et al, 2010;Wolinsky et al, 2012). Among them electrospun fibers are known as an excellent drug carrier by providing large surface area to volume for high drug loading and encapsulation efficiency, and a three-dimensional open porous structure, which can reduce the constraint to drug diffusion leading to an increase in the total fraction of drug that can be released (Qi et al, 2010;Wang et al, 2012;Zheng et al, 2013b). In addition, electrospinning affords great flexibility in producing polymer fibers with customizable fiber size, porosity, drug loading rate and release mechanisms, leading to a possibility of tailoring the drug release rate for each application.…”

Controlled Release of Drugs for Management of Pulpitis

“…Evaluation of the characteristics and antibacterial activity of amoxicillin-loaded electrospun nano-hydroxyapatite/PLGA composite nanofibers revealed that the loaded amoxicillin within the n-HA/PLGA hybrid nanofibers had a sustained release profile, significantly reduced burst-release profile, had a good biocompatibility, improved mechanical durability and optimal activity to inhibit the growth of the model bacterium, i.e. Staphylococcus aureus (18).…”

“…Several pharmacological and orthopedic studies have investigated the production of PLGA microspheres and have assessed the release of loaded antibiotics (16)(17)(18)(19)(20). In restorative dentistry, pulp-capping agents are used with the aim of eliminating microorganisms from the pulp chamber.…”

Antitumor Activity of Doxorubicin-Loaded Carbon Nanotubes Incorporated Poly(Lactic-Co-Glycolic Acid) Electrospun Composite Nanofibers

“…However, the simple introduction of drug into polymer matrix always leads to inevitable burst drug release, since the drug molecules might migrate on or near the fiber surfaces because of the high ionic strength in drug/ polymer solution and the rapid evaporation of the solvent during electrospinning. To address this limitation, it is highly desirable to develop efficient nanocarrier-mediated nanofibrous delivery systems which may serve as barrier for improving the safety of anticancer drugs and avoid drug premature burst release under physiological conditions [7,[17][18][19][20][21]. In fact, several nanoscale carriers such as mesoporous silica nanoparticles [22], hydroxyapatite [10], and liposome [23] have recently been incorporated into electrospun nanofibers for potential anticancer therapy, from which the prolonged drug release with tunable drug release kinetics could be achieved.…”