“…It is reported that AgNPs in the size range 1–10 nm can easily attach to the surface of cell membrane. This potentiality of AgNPs interfere with cell respiration and its permeability (Senthilkumar et al, 2017, Jose et al, 2016a, Jose et al, 2016b). Kavitha et al (2014) reported that NPs with 7 nm size was also synthesized using sodium borohydride (NaBH4), but in the present study AgNPs with similar size was prepared using green synthesis method and this bio inspired NPs are more safer than that prepared by chemical methods.Fig.…”
The present study is to investigate the antitumor, antioxidant and antibacterial potential of silver nanoparticles (Ag NPs) synthesized from a phenolic derivative 4-N-methyl benzoic acid, isolated from a medicinal plant (
Memecylon umbellatum Burm F
). The Bio-inspired nanoparticles (NPs) were analyzed by using UV–vis spectroscopy, FTIR, HRTEM, Zeta potential and XRD techniques. The UV–vis spectroscopy study at the band of 430 nm confirmed the nanoparticles formation. HRTEM report showed that the AgNPs synthesized were in the size range 7–23 nm. The harvested nanoparticles were subjected to anti-bacterial assay and a dose dependent inhibitory action was observed against the tested human pathogens. Among the tested bacteria,
Acinetobacter baumannii
was found to be highly sensitive to AgNPs (diameter of zone of inhibition was 31 mm). Further, the silver nanoparticles exhibited a good anti-tumor activity against the breast cancer cell line (MCF 7) with an IC
50
value of 42.19 µg/mL. As the present study confirmed a good antibacterial, antioxidant and antitumor activity in the nanoparticles synthesized using 4-N-methyl benzoic acid derived from a medicinal plant, the product can be further tested to formulate a good lead compound for biomedical applications.
“…It is reported that AgNPs in the size range 1–10 nm can easily attach to the surface of cell membrane. This potentiality of AgNPs interfere with cell respiration and its permeability (Senthilkumar et al, 2017, Jose et al, 2016a, Jose et al, 2016b). Kavitha et al (2014) reported that NPs with 7 nm size was also synthesized using sodium borohydride (NaBH4), but in the present study AgNPs with similar size was prepared using green synthesis method and this bio inspired NPs are more safer than that prepared by chemical methods.Fig.…”
The present study is to investigate the antitumor, antioxidant and antibacterial potential of silver nanoparticles (Ag NPs) synthesized from a phenolic derivative 4-N-methyl benzoic acid, isolated from a medicinal plant (
Memecylon umbellatum Burm F
). The Bio-inspired nanoparticles (NPs) were analyzed by using UV–vis spectroscopy, FTIR, HRTEM, Zeta potential and XRD techniques. The UV–vis spectroscopy study at the band of 430 nm confirmed the nanoparticles formation. HRTEM report showed that the AgNPs synthesized were in the size range 7–23 nm. The harvested nanoparticles were subjected to anti-bacterial assay and a dose dependent inhibitory action was observed against the tested human pathogens. Among the tested bacteria,
Acinetobacter baumannii
was found to be highly sensitive to AgNPs (diameter of zone of inhibition was 31 mm). Further, the silver nanoparticles exhibited a good anti-tumor activity against the breast cancer cell line (MCF 7) with an IC
50
value of 42.19 µg/mL. As the present study confirmed a good antibacterial, antioxidant and antitumor activity in the nanoparticles synthesized using 4-N-methyl benzoic acid derived from a medicinal plant, the product can be further tested to formulate a good lead compound for biomedical applications.
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