2018
DOI: 10.17265/2328-2150/2018.07.003
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Characterization and Antitumor Activity of Chitosan/Poly (Vinyl Alcohol) Blend Doped with Gold and Silver Nanoparticles in Treatment of Prostatic Cancer Model

Abstract: Abstract:The application of nanotechnology in various fields of science has earned a great concern over the past decades. The natural products and surface-modified polymers and metallic nanoparticles (NPs) have evolved as promising nanomaterials for targeted prostate cancer treatment. In the present study, Chitosan/poly (vinyl alcohol) (Cs/PVA) blend was synthesized by gamma radiation which could behave a nanoreactor for silver (Ag) and gold (Au) nanoparticle with promising anticancer applications. (Cs/PVA/Ag)… Show more

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Cited by 10 publications
(5 citation statements)
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“…(Table 1). However, the physicochemical properties, and surface modifications of CS play a crucial role in the cytotoxic profile and targeting of cancers that are characterized by rapid division and aggressive growth [21,23]. Furthermore, by assessing the in-vitro cytotoxic effect of various concentrations of the Cs/PVA/AuNP, against HepG2 cell lines, the survival fraction was found to be 55.8% and 66.7% in hydrogel concentration of (1:9) and (4:6) with 250 ppm AuNP at 50 μg/mL.…”
Section: Resultsmentioning
confidence: 99%
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“…(Table 1). However, the physicochemical properties, and surface modifications of CS play a crucial role in the cytotoxic profile and targeting of cancers that are characterized by rapid division and aggressive growth [21,23]. Furthermore, by assessing the in-vitro cytotoxic effect of various concentrations of the Cs/PVA/AuNP, against HepG2 cell lines, the survival fraction was found to be 55.8% and 66.7% in hydrogel concentration of (1:9) and (4:6) with 250 ppm AuNP at 50 μg/mL.…”
Section: Resultsmentioning
confidence: 99%
“…Previously, Roa et al [39] in 2009 also reported the toxicity of AuNPs alone in prostatic cancer, it was 10% with cell proliferation assays. Additionally, Abaza et al [23] in 2018, assessed the cytotoxic effect of various concentrations of Au-doped Chitosan/poly (vinyl alcohol) (Cs/PVA/AuNP) in prostatic cancer (PC3) cell cultures. The survival fraction was 24.8% and 23.8 % in concentration of (4:6) and (1:9) with 250 ppm AuNP.…”
Section: Resultsmentioning
confidence: 99%
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“…It has numerous advantages over viral vectors, such as safety and low immunogenicity [ 110 ]. In cancer research, several studies showed that siRNA-loaded CS-based nanoparticles are a promising therapeutic strategic [ 98 , 111 , 112 , 113 ]. Furthermore, CS was used as a carrier for in vivo delivery of interference agents such as siRNA [ 114 ].…”
Section: Other Biomedical Applicationsmentioning
confidence: 99%
“…Some sterilization methods may affect the mechanical and chemical properties of the scaffold [121]. PVA-CS nanoparticles are pH-dependent [98], which means that their physicochemical properties change with the change in pH. Therefore, their stability and functionality can be affected by changes in the pH of the surrounding environment.…”
Section: Challenges and Limitationsmentioning
confidence: 99%