Characterization and applicability of low-density materials for making 3D physical anthropomorphic breast phantoms

Santos, João; Almeida, Claudio Domingues; Iwahara, Akira; Peixoto, João Emílio

doi:10.1016/j.radphyschem.2019.108361

Cited by 16 publications

(5 citation statements)

References 13 publications

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“…The idea for using Veroclear came from the fact that it simulates polymethyl methacrylate (PMMA), [ 65 ] and PMMA has been used as electronegative layer in TENGs. [ 46 ] J.C. Santos et al [ 66 ] conducted an experiment by taking PMMA as the reference material for 3D printing of glandular tissues in breast phantom and tried several other polymers including Veroclear as a substitute for PMMA. They found that Veroclear showed reasonable equivalence with PMMA in required properties but until now 3D Veroclear has not been explored for the development of TENG.…”

Section: Methodsmentioning

confidence: 99%

Development of Triboelectric Nanogenerators Using Novel 3D Printed Polymer Materials

Wajahat,

Kouzani,

Khoo

et al. 2023

Adv Eng Mater

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Triboelectric nanogenerators (TENGs) are becoming attractive devices for harvesting mechanical energy. 3D printing (3DP) is a newly reported technique for the development of this device. This technique is not fully explored for the fabrication of triboelectric materials and compatible printing processes. Herein, three main 3DP techniques including powder‐based multijet fusion, resin‐based polyjet fusion, and filament‐based fused deposition modeling are utilized to investigate new sets of 3DP triboelectric materials. Mechanical to electrical conversion efficiency of 3D printed and commercially available negative and positive triboelectric materials are compared and investigated. Polyamide ‐12 (PA12), Veroclear, acrylonitrile‐styrene‐acrylate (ASA), copper‐coated polylactic acid (Cu‐PLA), polycarbonate (PC), and polyethylene terephthalate glycol (PETG) are fabricated using compatible 3D printing techniques. 3D‐printed PA12 is considered as a reference positive triboelectric layer. Meanwhile, 3D‐printed Veroclear, ASA, Cu‐PLA, PC, PETG, and commercial materials like Teflon sheets, PA6,6 conductive sheets, indium tin oxide‐coated polyethylene terephthalate, conductive‐nylon sheets, and PVDF membrane are selected as negative triboelectric materials. The maximum AC voltage of 80 V and maximum instantaneous current of 0.9 μA are produced by pairing 3DP‐PA12 and 3DP‐Veroclear under open circuit condition. This AC output is further converted to DC output using brdige rectifier circuitry to efficiently charge up the capacitor and glow series of 16 LEDs.

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Section: Methodsmentioning

confidence: 99%

Development of Triboelectric Nanogenerators Using Novel 3D Printed Polymer Materials

Wajahat,

Kouzani,

Khoo

et al. 2023

Adv Eng Mater

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“…(2) Contrast-enhanced digital mammography (CEDM): injecting a contrast agent (iohexol) to increase the image contrast of tumor tissue, which helps to distinguish the healthy fibroglandular tissue tissue and tumor tissue with close absorption attenuation coefficient in the dense breast. Therefore, cancerous tissues can be highlighted in CEDM imaging (Santos et al 2019). (3) Digital breast tomosynthesis (DBT): performing three-dimensional reconstruction to achieve three-dimensional characterization of the breast tissue (Rossman et al 2019).…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, tissue substitutes are specially designed to reproduce the tissues effective atomic number and linear attenuation coefficient. Breast phantoms have the potential to improve the treatment effort and verify novel techniques in the field of mammography (Santos et al 2019), and they are widely used in Quality Control and the dosimetry evaluation of diagnostic imaging equipment (Kimme-Smith et al 1989, Rizzo et al 1989, Faulkner et al 2010, Meghzifene et al 2010.…”

Section: Introductionmentioning

confidence: 99%

A new breast phantom suitable for digital mammography, contrast-enhanced digital mammography and digital breast tomosynthesis

Zhang¹,

Fu²

2023

Phys. Med. Biol.

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Our objective is to report a new breast phantom that provides the objective assessment for three types of clinical mammography, i.e. digital mammography (DM), contrast-enhanced digital mammography (CEDM), and digital breast tomosynthesis (DBT). The tissue-equivalent materials are used to represent the corresponding tissue, and the layer-by-layer structure with separate regions is designed for image quality assessment of different mammography modes. For DM imaging, substitutes for microcalcifications and fibroglandular tissue of different sizes are used to simulate the conventional breast. For CEDM imaging, the tumor module that can be injected with imaging contrast agents is adopted to distinguish normal tissue and diseased tissue in the dense breast. For DBT imaging, the overlapping breast mass module with multiple layers is designed to perform the layer-by-layer imaging of overlapping tissue. In addition, the quantitative assessment module of image quality is designed based on contrast-to-noise ratio (CNR), modulation transfer function (MTF) and artifact spread function (ASF). This phantom allows image quality to be evaluated objectively for three different types of the clinical mammography, while it provides an effective tool for optimizing the dose-image quality relationship of patients.

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“…Most of these phantoms are limited to printing the glandular and the adipose tissues, which are the main breast tissues. Attempts to print breast phantoms with lesions were recently reported by few authors (Di Franco et al 2019, Dukov et al 2019, Dukov et al 2021, showing that suitable materials for printing breast abnormalities are still to be developed and investigated for x-ray applications (Ivanov et al 2018, Santos et al 2019. Much effort has been devoted to the development of new 3D printing materials like, photopolymers doped with different concentration of TiO 2 , calcium, iodine and zinc (Sikaria et al 2016, Zhao et al 2017.…”

Section: Introductionmentioning

confidence: 99%

Thermoplastic 3D printing technology using a single filament for producing realistic patient-derived breast models

Dukov

Bliznakova

Okkalidis³

et al. 2022

Phys. Med. Biol.

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Objective. This work describes an approach for producing physical anthropomorphic breast phantoms from clinical patient data using three-dimensional (3D) fused-deposition modelling (FDM) printing. Approach. The source of the anthropomorphic model was a clinical Magnetic Resonance Imaging (MRI) patient image set, which was segmented slice by slice into adipose and glandular tissues, skin and tumour formations; thus obtaining a four component computational breast model. The segmented tissues were mapped to specific Hounsfield Units (HU) values, which were derived from clinical breast Computed Tomography (CT) data. The obtained computational model was used as a template for producing a physical anthropomorphic breast phantom using 3D printing. FDM technology with only one polylactic acid filament was used. The physical breast phantom was scanned at Siemens SOMATOM Definition CT. Quantitative and qualitative evaluation were carried out to assess the clinical realism of CT slices of the physical breast phantom. Main results. The comparison between selected slices from the computational breast phantom and CT slices of the physical breast phantom shows similar visual x-ray appearance of the four breast tissue structures: adipose, glandular, tumour and skin. The results from the task-based evaluation, which involved three radiologists, showed a high degree of realistic clinical radiological appearance of the modelled breast components. Measured HU values of the printed structures are within the range of HU values used in the computational phantom. Moreover, measured physical parameters of the breast phantom, such as weight and linear dimensions, agree very well with the corresponding ones of the computational breast models. Significance. The presented approach, based on a single FDM material, was found suitable for manufacturing of a physical breast phantom, which mimics well the 3D spatial distribution of the different breast tissues and their x-ray absorption properties. As such, it could be successfully exploited in advanced x-ray breast imaging research applications.

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Characterization and applicability of low-density materials for making 3D physical anthropomorphic breast phantoms

Cited by 16 publications

References 13 publications

Development of Triboelectric Nanogenerators Using Novel 3D Printed Polymer Materials

Development of Triboelectric Nanogenerators Using Novel 3D Printed Polymer Materials

A new breast phantom suitable for digital mammography, contrast-enhanced digital mammography and digital breast tomosynthesis

Thermoplastic 3D printing technology using a single filament for producing realistic patient-derived breast models

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