Characterization and application of Borassus aethiopum (Arecaceae) shoot pregelatinized starch as binding agent in paracetamol tablets

Azubuike, Chukwuemeka; Ubani-Ukoma, Uloma; Madu, Shadrack Joel; Yomi-Faseun, Oluwateniola; Yusuf, Suliat

doi:10.4103/jrptps.jrptps_29_18

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…Further, there is no need to conduct mass uniformity and friability test because the hardness values are low. The character of PPCS indicated a better dissolution profile (Azubuike et al, 2019).…”

Section: Evaluation Of Tabletsmentioning

confidence: 97%

The effect of partially pregelatinized cassava starch as disintegrant for paracetamol tablet

Putra¹,

Auli²,

Musa³

et al. 2022

Pharmaciana

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The use of partially pregelatinized starch in tablet formulations is entirely various; one of them is disintegrant. Present pregelatinized starch is imported from another country, which is relatively expensive. In contrast, many plants can be used as starch sources, including cassava which is relatively abundant in Indonesia. This study aimed to determine the effect of using partially pregelatinized starch from cassava as a disintegrant in paracetamol tablets. In this study, seven formulas were used with different disintegrants, three formulas using partially pregelatinized starch from cassava with concentrations of F1 5%, F2 10%, and F3 15%, three formulas using Starch 1500 with the same concentration as partially pregelatinized starch from cassava and one control formula without disintegrant. The tablet was made using the wet granulation method. The tablets produced were tested for physical properties (hardness, disintegration, and dissolution). In addition, compact ability of partially pregelatinized starch from cassava was compared with Avicel, Starch 1500, and cassava starch. Based on the results of the study showed that partially pregelatinized starch from cassava produced tablets that tended to be capping with less hardness than tablets with Starch 1500 and control tablets. The compact ability test results showed that the compact ability of partially pregelatinized starch from cassava was better than Starch 1500 and cassava starch. The disintegration test results showed that tablets with partially pregelatinized starch from cassava had faster disintegration than tablets with Starch 1500 and control tablets. The dissolution profile of tablets with partially pregelatinized starch from cassava is also better than other formulas.

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Section: Evaluation Of Tabletsmentioning

confidence: 97%

The effect of partially pregelatinized cassava starch as disintegrant for paracetamol tablet

Putra¹,

Auli²,

Musa³

et al. 2022

Pharmaciana

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“…[19] Thus, this high water holding capacity of the starch blend can find its potential in formulation of hydrogels. [20,21]…”

Section: Water Holding Capacitymentioning

confidence: 99%

Untitled

Kumar¹

2021

AJP

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Aim:The aim of the study was to evaluate the potential synergistic effect of natural and thermally modified starch blends from maize and potato. Materials and Methods: The maize and potato starches were combined in proportions of 1:1 (NSB1) and 1:2 (NSB2) and thermally treated (pregelatinization and retrogradation). For their application as excipients, these thermally treated starch blends were compared to natural starch blends for physicochemical parameters such as moisture content, water holding capacity, swelling and solubility, and amylose concentration. Results and Discussion: The amylose content of the heat-treated gums increased, indicating that it could be used in colon medication administration. The increase in water holding capacity from 218.13 ± 0.13% to 732.27 ± 0.34% demonstrates its promise in hydrogel creation. The moisture percentage of all the blends was in the range of 10.10 ± 0.03%-15.42 ± 0.03%, which were well within the range specified in Indian Pharmacopoeia. All of the samples' pH levels were determined to be mildly basic (7.15-7.46). Conclusion: The potato and maize modified starch blends demonstrated a promising synergistic impact compared to native blends as an adjuvant in the formulation of various drug delivery systems.

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Enhancing delayed release characteristics of chapparada avare seed starch

Singh

Kumar

2020

International Journal of Biological Macromolecules

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Characterization and application of Borassus aethiopum (Arecaceae) shoot pregelatinized starch as binding agent in paracetamol tablets

Cited by 5 publications

References 24 publications

The effect of partially pregelatinized cassava starch as disintegrant for paracetamol tablet

The effect of partially pregelatinized cassava starch as disintegrant for paracetamol tablet

Untitled

Enhancing delayed release characteristics of chapparada avare seed starch

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