Characterization and biocompatibility evaluation of acellular rat skin scaffolds for skin tissue engineering applications

Momen, Leila Taghizadeh; Abdolmaleki, Arash; Asadi, Asadollah; Zahri, Saber

doi:10.1007/s10561-023-10109-w

Cited by 4 publications

(1 citation statement)

References 61 publications

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“…The use of acellular scaffolds can be an important step in the treatment of skin diseases such as ichthyosis (19).…”

Section: Discussionmentioning

confidence: 99%

Investigating the Genetic Cause of Ichthyosis Disease in a Family with Exome Sequencing

Ghalavandi,

Khoshnood

2024

Gene Cell Tissue

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Background: Ichthyosis is a diverse skin disease characterized by dry skin and itching, particularly affecting the hands. Most forms of this condition are hereditary. Objectives: In this study, we investigated potential new mutations associated with this disease using the new technique of whole-exome sequencing. Methods: In this study, after collecting the patient's blood sample in an EDTA tube and extracting DNA using the salting-out method, next-generation sequencing was performed using the WES method. Following the analysis of the results and identification of the candidate gene, PCR technique and Chromas software were used to confirm the findings. Results: The results indicated the presence of a new variant, NM_001099287: Exon 6:c.C1083A: p.Y361X, in the NIPAL4 gene in a heterozygous form in the parents and a homozygous form in the patient. This variant occurred as a nucleotide substitution in the exon 6 region of the NIPAL4 mRNA sequence. Conclusions: Using the WES technique, it is possible to investigate the presence of new variants related to ichthyosis in a short time and at a low cost.

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“…The use of acellular scaffolds can be an important step in the treatment of skin diseases such as ichthyosis (19).…”

Section: Discussionmentioning

confidence: 99%

Investigating the Genetic Cause of Ichthyosis Disease in a Family with Exome Sequencing

Ghalavandi,

Khoshnood

2024

Gene Cell Tissue

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Exploiting the Potential of Decellularized Extracellular Matrix (ECM) in Tissue Engineering: A Review Study

Brouki Milan,

Masoumi,

Biazar

et al. 2024

Macromolecular Bioscience

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While significant progress has been made in creating polymeric structures for tissue engineering, the therapeutic application of these scaffolds remains challenging owing to the intricate nature of replicating the conditions of native organs and tissues. The use of human‐derived biomaterials for therapeutic purposes closely imitates the properties of natural tissue, thereby assisting in tissue regeneration. Decellularized extracellular matrix (dECM) scaffolds derived from natural tissues have become popular because of their unique biomimetic properties. These dECM scaffolds can enhance the body's ability to heal itself or be used to generate new tissues for restoration, expanding beyond traditional tissue transfers and transplants. Enhanced knowledge of how ECM scaffold materials affect the microenvironment at the injury site is expected to improve clinical outcomes. In this review, recent advancements in dECM scaffolds are explored and relevant perspectives are offered, highlighting the development and application of these scaffolds in tissue engineering for various organs, such as the skin, nerve, bone, heart, liver, lung, and kidney.

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Evaluation of decellularized sheep kidney scaffolds for renal tissue engineering: Biocompatibility and stem cell differentiation potential

Jahanvar,

Zahri,

Abdolmaleki

et al. 2024

Tissue and Cell

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Characterization and biocompatibility evaluation of acellular rat skin scaffolds for skin tissue engineering applications

Cited by 4 publications

References 61 publications

Investigating the Genetic Cause of Ichthyosis Disease in a Family with Exome Sequencing

Investigating the Genetic Cause of Ichthyosis Disease in a Family with Exome Sequencing

Exploiting the Potential of Decellularized Extracellular Matrix (ECM) in Tissue Engineering: A Review Study

Evaluation of decellularized sheep kidney scaffolds for renal tissue engineering: Biocompatibility and stem cell differentiation potential

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