Characterization and biological studies on Co(II), Ni(II) and Cu(II) complexes of carbohydrazones ending by pyridyl ring

El‐Reash, G.M. Abu; El‐Gammal, O.A.; Ghazy, S. E.; Radwan, Ali

doi:10.1016/j.saa.2012.11.008

Cited by 80 publications

(39 citation statements)

References 55 publications

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“…Both hydrazine groups of carbohydrazide display reactivity toward carbonyl compounds and give rise to a large number of crystalline mono-and dihydrazones. Carbohydrazones and their complexes with transition metals have been found to be one of the most fascinating subjects in the field of coordination chemistry as they are documented in the literature as good therapeutic, antimicrobial, anticancer, and pharmacological agents [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectral, X-ray diffraction, antimicrobial studies, and DNA binding properties of binary and ternary complexes of pentadentate N2O3 carbohydrazone ligands

Shebl

Khalil

2014

Monatsh Chem

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Two pentadentate carbohydrazone ligands, H 2 L 1 and H 2 L 2 , were prepared by the reaction of the bifunctional compound carbohydrazide with 2-hydroxy-5-nitrobenzaldehyde and 2-hydroxy-1-naphthaldehyde, respectively. Reactions of the ligands with oxovanadium(IV), cerium(III), thorium(IV), and dioxouranium(VI) ions yielded binary complexes. Reactions of the ligands with the dioxouranium(VI) ion in the presence of secondary ligands (8-hydroxyquinoline, glycine, salicylaldehyde, or benzoylacetone) yielded ternary complexes. The ligands and metal complexes were characterized by different techniques such as elemental and thermal analyses, IR, 1 H and 13 C NMR, electronic, ESR, mass spectra, and powder XRD as well as magnetic susceptibility and conductivity measurements. The coordinating sites are phenolic oxygen, azomethine nitrogen, and carbonyl oxygen. In complexes, the ligands act as dibasic pentadentate except ternary dioxouranium(VI) complexes, obtained using glycine or benzoylacetone, in which the ligands act as monobasic pentadentate. The XRD patterns for the H 2 L 1 ligand, its binary dioxouranium(VI) complex, and its 8-hydroxyquinoline ternary complex indicate crystalline nature and the grain size was estimated. The H 2 L 1 ligand and its binary complex have triclinic systems while the ternary complex has a monoclinic system with different unit-cell parameters. The ligands and some of their metal complexes showed antimicrobial activity toward some Gram-positive and Gram-negative bacteria, yeast (Candida albicans), and fungus (Aspergillus fumigatus), and MIC values were determined. The DNA binding properties of the oxovanadium(IV) complexes of H 2 L 1 and H 2 L 2 ligands were investigated by electronic absorption spectroscopy and viscosity measurements. The results indicated that these complexes bind to DNA via an intercalation binding mode with an intrinsic binding constant K b of 2.55 9 10 4 and 3 9 10 4 M -1 , respectively.

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Section: Introductionmentioning

confidence: 99%

Synthesis, spectral, X-ray diffraction, antimicrobial studies, and DNA binding properties of binary and ternary complexes of pentadentate N2O3 carbohydrazone ligands

Shebl

Khalil

2014

Monatsh Chem

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“…In case of ligand (H 2 L); the energy gap is small also due to the groups that enter conjugation. This indicates that charge transfer easily, which influences the biological activity of the molecule [49].…”

Section: N(10)-c(9) O(14)-c(9)-n(10) O(14)-c(9)-c(8) O(13)-c(8)-n(7)mentioning

confidence: 96%

2-(2-(2-Hydroxybenzyliden) Hydrazinyl)-2-Oxo-N-(Pyridine-2-Yl) Acetamide Complexes: Synthesis, Characterization and Biological Studies

El-Reash¹,

Zaky²,

Yaseen³

2016

Chem Sci J

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Citation: El-Reash YGA, Zaky R, Yaseen MA (2016) 2-(2-(2-Hydroxybenzyliden) Hydrazinyl)-2-Oxo-N-(Pyridine-2-Yl) Acetamide Complexes: Synthesis, Characterization and Biological Studies. Chem Sci J 7: 145. doi: 10.4172/2150-3494.1000145 Copyright: © 2016 El-Reash YGA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Keywords: Hydrazones; DFT; DND; Potentiometry IntroductionHydrazones are versatile ligands and possessing an azomethine -NHN=CH-proton groups. They can be described by the following general structure R 2 C = NNR 2 . Hydrazone ligands and their metal complexes were attracted many authors because of their varied applications in biological, pharmaceutical, analytical, catalytic [1][2][3][4][5] and industrial fields. Hydrazones and their coordination compounds play important roles in treatment of different diseases. Hydrazones considered as an significant class of compounds with wide importance due to their various biological applications such as anticonvulsant, analgesic, antidepressant, antimalarial, antiplatelet, antimycobacterial, antimicrobial, antiviral, anticancer, antidiabetic, vasodilator, anthelmintic,. This work targets the synthesize and characterization Co(II) and Ni(II) complexes of 2-(2-(2-hydroxybenzyliden) hydrazinyl)-2-oxo-N-(pyridine-2-yl) acetamid (H 2 L). The geometry and modes of chelation of complexes were discussed based on the resulted (DFT) quantum calculations, the magnetic moment, the different spectroscopic methods ( 1 H and 13 C-NMR, UV-visible, IR, EI-mass). Moreover, the thermal decomposition steps were studied and both the kinetics and thermodynamic factors were determined using Coats-Redfern and Horowitz-Metzger models. In addition, potentiometric titrations were done in 50% DMSO-water mixture at various temperatures (298, 308 and 318 K) respectively. Moreover, their Minimum inhibitory concentration (MIC) and DNA-binding affinity assay were tested. (C, H and N) percent presented in the prepared ligand (H 2 L) and complexes were detected using a Perkin-Elmer 2400 series II analyzer, while chloride and metal contents determined using standard methods reported previously [15]. A thermogravimetric analyzer (TGA-50H) from Shimadzu, Japan, used for both thermogravimetric (TGA) and differential thermal analysis (DTA) measurements with a heating rate of 10°C/min on at temperature range (20-800°C) and nitrogen flow rate of 15 ml/min. A Sherwood Magnetic Balance was utilized to measure the magnetic susceptibility of solid complexes. A Mattson 5000 FTIR spectrophotometer was used to analyze the prepared ligand and complexes under range of (4000-400 cm -1 ) in KBr discs. While; the electronic spectra of complexes (in DMSO solution) was recorded using a Perkin Elmer Lamda 25 UV/Vis Spectrophotometer. 1 H, 13 C-NMR measurements were done on Mercury and Gemini 400 MHZ spectrome...

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“…The molecules with a small energy gap are more polarized and reactive than hard ones because they easily offer electrons to an acceptor. Also, the low values of energy gap may be due to the groups entering into conjugation in those soft molecules [47]. The energy gap in complexes is smaller than that in H 2 BHAH which enhances the biological activity of some metal complexes than the ligand.…”

Section: Molecular Modelingmentioning

confidence: 99%

Bivalent transition metal complexes of (E)-3-(2-benzylidenehydrazinyl)-3-oxo-N-(p-tolyl)propanamide: Spectroscopic, computational, biological activity studies

Zaky

Ibrahim

El-Nadar

et al. 2015

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Characterization and biological studies on Co(II), Ni(II) and Cu(II) complexes of carbohydrazones ending by pyridyl ring

Cited by 80 publications

References 55 publications

Synthesis, spectral, X-ray diffraction, antimicrobial studies, and DNA binding properties of binary and ternary complexes of pentadentate N2O3 carbohydrazone ligands

Synthesis, spectral, X-ray diffraction, antimicrobial studies, and DNA binding properties of binary and ternary complexes of pentadentate N2O3 carbohydrazone ligands

2-(2-(2-Hydroxybenzyliden) Hydrazinyl)-2-Oxo-N-(Pyridine-2-Yl) Acetamide Complexes: Synthesis, Characterization and Biological Studies

Bivalent transition metal complexes of (E)-3-(2-benzylidenehydrazinyl)-3-oxo-N-(p-tolyl)propanamide: Spectroscopic, computational, biological activity studies

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