Characterization and comparative analyses of zebrafish intelectins: Highly conserved sequences, diversified structures and functions

Lin, Bin; Cao, Zhen; Su, Peng; Zhang, Haibo; Li, Mengzhen; Lin, Yiqun; Zhao, Dezhi; Shen, Yang; Jing, Chenfeng; Chen, Shangwu; Xu, Anlong

doi:10.1016/j.fsi.2008.11.019

Cited by 43 publications

(39 citation statements)

References 27 publications

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“…Members of a family of immune-related, lectin-like receptors (illrs), showing structural similarity to mammalian C-type lectin natural killer cell receptors, are differentially expressed in the myeloid and lymphoid lineages [129]. In a family of 7 intelectins (X-lectins), one member ( zINTL-3 ) was upregulated in adult fish tissues upon Aeromonas salmonicida infection [130]. …”

Section: Pattern Recognition Receptors In Zebrafishmentioning

confidence: 99%

Host-Pathogen Interactions Made Transparent with the Zebrafish Model

Meijer¹,

Spaink²

2011

CDT

219

216

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The zebrafish holds much promise as a high-throughput drug screening model for immune-related diseases, including inflammatory and infectious diseases and cancer. This is due to the excellent possibilities for in vivo imaging in combination with advanced tools for genomic and large scale mutant analysis. The context of the embryo’s developing immune system makes it possible to study the contribution of different immune cell types to disease progression. Furthermore, due to the temporal separation of innate immunity from adaptive responses, zebrafish embryos and larvae are particularly useful for dissecting the innate host factors involved in pathology. Recent studies have underscored the remarkable similarity of the zebrafish and human immune systems, which is important for biomedical applications. This review is focused on the use of zebrafish as a model for infectious diseases, with emphasis on bacterial pathogens. Following a brief overview of the zebrafish immune system and the tools and methods used to study host-pathogen interactions in zebrafish, we discuss the current knowledge on receptors and downstream signaling components that are involved in the zebrafish embryo’s innate immune response. We summarize recent insights gained from the use of bacterial infection models, particularly the Mycobacterium marinum model, that illustrate the potential of the zebrafish model for high-throughput antimicrobial drug screening.

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Section: Pattern Recognition Receptors In Zebrafishmentioning

confidence: 99%

Host-Pathogen Interactions Made Transparent with the Zebrafish Model

Meijer¹,

Spaink²

2011

CDT

219

216

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“…Interestingly, zINTL3 was expressed predominantly in the liver and highly upregulated upon infection, suggesting its important roles in immunity. Further, a comparative analysis with intelectins from various species revealed that the XL/intelectin family may be unique to deuterostomes, and in spite of their sequence conservation, expression patterns, quaternary structures and glycosylations are diverse among species (Lin et al, 2009). …”

Section: The Zebrafish (D Rerio) As a Model For Glycoimmunologymentioning

confidence: 99%

Structural and functional diversity of the lectin repertoire in teleost fish: Relevance to innate and adaptive immunity

Vasta

Niță-Lazăr

Giomarelli

et al. 2011

Developmental & Comparative Immunology

150

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Protein–carbohydrate interactions mediated by lectins have been recognized as key components of innate immunity in vertebrates and invertebrates, not only for recognition of potential pathogens, but also for participating in downstream effector functions, such as their agglutination, immobilization, and complement-mediated opsonization and killing. More recently, lectins have been identified as critical regulators of mammalian adaptive immune responses. Fish are endowed with virtually all components of the mammalian adaptive immunity, and are equipped with a complex lectin repertoire. In this review, we discuss evidence suggesting that: (a) lectin repertoires in teleost fish are highly diversified, and include not only representatives of the lectin families described in mammals, but also members of lectin families described for the first time in fish species; (b) the tissue-specific expression and localization of the diverse lectin repertoires and their molecular partners is consistent with their distinct biological roles in innate and adaptive immunity; (c) although some lectins may bind endogenous ligands, others bind sugars on the surface of potential pathogens; (d) in addition to pathogen recognition and opsonization, some lectins display additional effector roles, such as complement activation and regulation of immune functions; (e) some lectins that recognize exogenous ligands mediate processes unrelated to immunity: they may act as anti-freeze proteins or prevent polyspermia during fertilization.

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“…The C-terminal 2/3 sequence, termed the Intelectin domain by Lin et al [11], is highly conserved and unique within the intelectin gene family. Potential N-glycosylation sites were not identified by NetNGlyc 1.0.…”

Section: Cloning Sequence Comparison and Phylogenetic Analysis Of Amentioning

confidence: 99%

Identification of an amphioxus intelectin homolog that preferably agglutinates gram-positive over gram-negative bacteria likely due to different binding capacity to LPS and PGN

Yan

Wang

Zhao

et al. 2012

Fish & Shellfish Immunology

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Characterization and comparative analyses of zebrafish intelectins: Highly conserved sequences, diversified structures and functions

Cited by 43 publications

References 27 publications

Host-Pathogen Interactions Made Transparent with the Zebrafish Model

Host-Pathogen Interactions Made Transparent with the Zebrafish Model

Structural and functional diversity of the lectin repertoire in teleost fish: Relevance to innate and adaptive immunity

Identification of an amphioxus intelectin homolog that preferably agglutinates gram-positive over gram-negative bacteria likely due to different binding capacity to LPS and PGN

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