Characterization and cytotoxicity studies of DPPC:M2+ novel delivery system for cisplatin thermosensitivity liposome with improving loading efficiency

Liu, Hong; Zhang, Yongle; Han, Yazhu; Zhao, Sha; Wang, Lu; Zhang, Zhaoxin; Wang, Jing; Cheng, Jianxin

doi:10.1016/j.colsurfb.2015.04.029

Cited by 19 publications

(8 citation statements)

References 40 publications

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“…This is further supported by fluorescence studies showing that the influence of ions in the aqueous environment (e.g., Ca 2+ , Mn 2+ , Mg 2+ . Cu 2+ , and Zn 2 ) altered the fluidity of the membrane by interacting with phosphates (e.g., electrostatic complexation), which in turn resulted in higher encapsulation of cisplatin into LUV (Liang and Huang, 2002; Liu et al, 2015). These results seem to indicate a connection between the ability of platinum (II) complexes to establish electrostatic interactions in model membranes and decreased membrane fluidity induced by complexation with the headgroups.…”

Section: Cisplatin-membrane Interactionsmentioning

confidence: 99%

Cisplatin-Membrane Interactions and Their Influence on Platinum Complexes Activity and Toxicity

et al. 2019

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Cisplatin and other platinum(II) analogs are widely used in clinical practice as anti-cancer drugs for a wide range of tumors. The primary mechanism by which they exert their action is through the formation of adducts with genomic DNA. However, multiple cellular targets by platinum(II) complexes have been described. In particular, the early events occurring at the plasma membrane (PM), i.e., platinum-membrane interactions seem to be involved in the uptake, cytotoxicity and cell-resistance to cisplatin. In fact, PM influences signaling events, and cisplatin-induced changes on membrane organization and fluidity were shown to activate apoptotic pathways. This review critically discusses the sequence of events caused by lipid membrane-platinum interactions, with emphasis on the mechanisms that lead to changes in the biophysical properties of the membranes (e.g., fluidity and permeability), and how these correlate with sensitivity and resistance phenotypes of cells to platinum(II) complexes.

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Section: Cisplatin-membrane Interactionsmentioning

confidence: 99%

Cisplatin-Membrane Interactions and Their Influence on Platinum Complexes Activity and Toxicity

et al. 2019

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“…The successful encapsulation of anthracyclines with high efficiency prompted the search for other molecules with high encapsulation efficiency. Liu et al [54] reported that using metal ions such as Zn or Cu could lead to high efficacy in encapsulation of cisplatin. Moreover, the presence of metal bound liposomes increased the cytotoxicity.…”

Section: Payloadsmentioning

confidence: 99%

Thermosensitive Liposomes

Motamarry¹,

Asemani²,

Haemmerich³

2017

Liposomes

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Thermosensitive liposomes (TSLs) are a drug delivery system for targeted delivery that release the encapsulated drug when heated to fever temperatures (∼40-42°C). Combined with localized hyperthermia, TSLs allow precise drug delivery to a targeted region. While mostly investigated as cancer therapy, other applications including treatment of local infections and wound healing have been explored. Over the last ∼40 years, numerous TSL formulations and payloads have been investigated. As with other nanoparticles, the addition of targeting molecules to TSL has been examined to improve targeted delivery. TSL release kinetics and plasma stability are two important factors that affect efficacy, and new formulations often aim to further improve on these properties. The possibility of encapsulating a magnetic resonance (MR) contrast agent that is released together with the encapsulated drug allows for visualization of drug delivery with MR imaging. Various heating modalities have been examined in combination with TSL. Since the goal is to expose a defined tissue region to uniform temperatures within the range where TSLs release (typically ∼40-43°C), the choice of an appropriate heating modality has considerable impact on treatment efficacy. Several ongoing clinical trials with TSL as cancer therapy suggest the potential for clinical impact in the near future. Figure 1. Current drug targeting strategies. (A) Conventional therapy or free drug infusion. (B) Passive targeting by liposomes utilizing EPR effect. (C) Active targeting of liposomes labeled with tumor-specific antibody. (D) Active targeting of liposomes with endothelial cell-specific antibody. (E) Triggered drug release either (1) within the tumor interstitium or (2) intravascular release. TSL fall into this last category reproduced with permission from Ref. [1].

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“…Moreover, HaT‐OXA and HaT‐GEM both exhibited an improved pharmacokinetic profile and further enhanced drug uptake in the heated tumor compared to the unheated tumor (by threefold and ninefold, respectively). Similarly, cisplatin‐loaded thermosensitive liposomes, consisted of dipalmitoylphosphatidylcholine (DPPC) with Mg 2+ , showed high cisplatin encapsulation efficiency and quick release at initial stage at 42 ± 0.5°C, with >40% release of the loaded cisplatin from liposomes within 10 min …”

Section: Controlled Releasementioning

confidence: 99%

“…Similarly, cisplatin-loaded thermosensitive liposomes, consisted of dipalmitoylphosphatidylcholine (DPPC) with Mg 2 + , showed high cisplatin encapsulation efficiency and quick release at initial stage at 42 AE 0.5 C, with >40% release of the loaded cisplatin from liposomes within 10 min. 97 Thermoresponsiveness can also be used to prevent drug release at undesired sites. For example, NIPAm is a well-known thermosensitive monomer with an LCST of 32 C. NIPAm units switch from hydrophilic to hydrophobic upon temperature induced polymerization above 32 C. Thus, NIPAm units were introduced into the nanogel structure to prevent the release of encapsulated cisplatin at 37 C. At the acidic tumor environment, the release of cisplatin from the NIPAm containing nanogels were accelerated by H + attacking.…”

Section: Thermosensitive Systemsmentioning

confidence: 99%

Multifunctional platinum‐based nanoparticles for biomedical applications

Cheng

Liu

2016

WIREs Nanomed Nanobiotechnol

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Platinum-based anticancer drugs play a central role in current cancer therapy. However, their applicability and efficacy are limited by drug resistance and adverse effects. Nanocarrier-based platinum drug delivery systems are promising alternatives to circumvent the disadvantages of bare platinum drugs. The various properties of nanoparticle chemistry allow for the trend toward multiple functionality. Nanoparticles preferentially accumulate at the tumor site through passive targeting, and the attachment of tumor targeting moieties further enhances their tumor-specific localization as well as tumor cell uptake. The introduction of stimuli-responsive groups into drug delivery systems can further achieve spatially and temporally controlled drug release in response to specific stimuli. Combination therapy strategies have been used to promote synergetic efficacy and overcome the resistance of platinum drugs. The tumor-localized drug delivery strategies exhibit benefits for preventing local tumor recurrence. In addition, the combination of platinum drugs and imaging agents in one unity allows the cancer diagnostics for real-time monitoring the distribution of drug-loaded nanoparticles inside the body and tumor. This review discusses recent scientific advances in multifunctional nanoparticle formulations of platinum drugs, and these designs exhibit new potential of multifunctional nanoparticles for delivering platinum-based anticancer drugs. WIREs Nanomed Nanobiotechnol 2017, 9:e1410. doi: 10.1002/wnan.1410 For further resources related to this article, please visit the WIREs website.

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Characterization and cytotoxicity studies of DPPC:M2+ novel delivery system for cisplatin thermosensitivity liposome with improving loading efficiency

Cited by 19 publications

References 40 publications

Cisplatin-Membrane Interactions and Their Influence on Platinum Complexes Activity and Toxicity

Cisplatin-Membrane Interactions and Their Influence on Platinum Complexes Activity and Toxicity

Thermosensitive Liposomes

Multifunctional platinum‐based nanoparticles for biomedical applications

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