Characterization and eradication of the high concentration infection source of oral segment of Candida by infection examination diagnosis system

Abstract

Purpose: Candida albicans (CA) is a major pathogenic fungus that causes a critical infection and life-threatening disease. Currently, during the treatment of COVID-19 (in ICU), invasive Candidiasis and Candida colonization should be prevented to avoid the increase, in mortality, in SAPSII, and in length of stay. Our aim was to characterize and analyze the infection of Candida albicans (CA) for eradication. Methods: We characterized and analyzed the infection source and infection field which are carrier field, diffusion field, and spread field, by using a new infection examination (diagnostic) system (IEDS) comprising a new dental formula (measurement analysis) medium (DFM) with time, space, and phase, and the simultaneous relative differential equations (C4RDE).Results: This study showed that CA was not an endogenous microorganism, but a fungus that infected teeth causing dental caries that was successfully eradicated from all teeth of 353 Japanese patients (oral cavity segment). [In the first examination, the percentages of people with CA (+) was 40.5% (the DMFT: 62.8%) and CA(-) was 56.4% (the DMFT: 47.1%). The difference in DMFT was 15.7% (P<0.01)] (DMFT is decayed, missing, and filled tooth index).Conclusion: Eradication of the infection source (IS) of the oral segment(s) and breaking the infection chain (IC) by IE(D)S will dramatically reduce the threat to the living body by pathogenic microorganisms. And, our methods help to eradicate the infection source (IS), prevent critical infection, and reduce mortality. The IEDS is a powerful tool that can be applied for any microbial infection easily. It is possible for the dentists to characterize CA by IEDS and eradicate CA from the oral cavity. Moreover, CA must consider the phase of the space-time of infection source, infection field, receptor field, resistance field, adhesive colony, fixed colony and infection chain. Moreover, CA must consider the phase of microorganisms. If they are neglected, the statistical research or the medical treatment etc., the study cannot obtain the correct result.