Characterization and evaluation of avermectin solid nanodispersion prepared by microprecipitation and lyophilisation techniques

Cui, Bo; Wang, Chunxin; Zhao, Xiang; Yao, Junwei; Zeng, Zhanghua; Wang, Yan; Sun, Changjiao; Liu, Guoqiang; Cui, Haixin

doi:10.1371/journal.pone.0191742

Cited by 20 publications

(11 citation statements)

References 44 publications

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“…In this investigation, the zeta potential of the abamectin nanosuspension was −36.9 ± 1.1 mV (Fig. ), similar to the result for the re‐dispersed suspension of the abamectin solid nanodispersion . Both polymer polycarboxylate and MRES act as steric stabilizers and may lead to a shift in the shear plane to a larger distance from the particle surface, resulting in a reduction in the measured potential .…”

Section: Resultssupporting

confidence: 82%

“…Based on our previous research, composite surfactant with a combination of polycarboxylate and MRES in a ratio of 1:1 (w/w) was optimized to stabilize abamectin nanoparticles. Because abamectin is prone to photolysis in aqueous solution and on leaves under UV radiation, UV329 was added as an ultraviolet absorbent to prevent photo‐decomposition of the pesticide.…”

Section: Resultsmentioning

confidence: 99%

“…2), similar to the result for the re-dispersed suspension of the abamectin solid nanodispersion. 26 Both polymer polycarboxylate and MRES act as steric stabilizers and may lead to a shift in the shear plane to a larger distance from the particle surface, resulting in a reduction in the measured potential. 44,46 In this condition, the high negative value demonstrates that the anionic surfactants were indeed adsorbed on the pesticide surface and provided strong electrostatic repulsion against aggregation.…”

Section: Zeta Potential and Phmentioning

confidence: 99%

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Improving abamectin bioavailability via nanosuspension constructed by wet milling technique

Cui

Gao

et al. 2019

Pest Management Science

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BACKGROUND Poorly water‐soluble and photosensitive pesticide compounds are difficult to be formulated as environmentally friendly formulations with high efficacy. Conventional wettable powder, emulsifiable concentrate and emulsion in water have disadvantages of dust drift, overuse of organic solvent and low efficacy. Therefore, there is an urgent need to construct a novel formulation to improve the bioavailability of pesticides. RESULTS An abamectin nanosuspension was developed using a wet‐milling method combined with orthogonal experimental design. The average particle sizes of the abamectin nanosuspension measured by dynamic light scattering, scanning electron microscope and transmission electron microscope were 233, 90 and 140 nm, respectively. The zeta potential and sliding angle on cabbage leaves were −36.9 mV and 62°. Retention and anti‐photolysis were around 1.5 and 1.6 times those of emulsions in water. Furthermore, the biological activity of the nanosuspension towards diamondback moths was approximately twice that of conventional formulations. CONCLUSION This study provides an easy and scalable technique for constructing pesticide nanosuspensions. The preparation and composition of the nanosuspension avoid the use of organic solvents. Application of the highly effective nanoformulation will significantly enhance pesticide efficacy, and reduce the dosage and environmental pollution of the pesticide. © 2019 Society of Chemical Industry

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Section: Resultssupporting

confidence: 82%

Section: Resultsmentioning

confidence: 99%

Section: Zeta Potential and Phmentioning

confidence: 99%

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Improving abamectin bioavailability via nanosuspension constructed by wet milling technique

Cui

Gao

et al. 2019

Pest Management Science

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“…However, IVM has a high a nity for organic matter resulting in reduced bioavailability in water, with half-life DT 50 of 39h in water and of 45d in sediment (Solomon et al, 2007). However, the bioavailability and half-life of IVM is seriously in uenced by conditions such as low water solubility and instability when exposed to UV or visible light (Cui et al, 2018) and may be less than 2ng/L in surface waters (Solomon et al, 2007). Nevertheless, and in eld conditions, namely in marine areas, IVM tends to stay for extremely long periods in the sediments, as shown by Roth et al (1993).…”

Section: Introductionmentioning

confidence: 99%

Effect of Sublethal Concentrations of the Antiparasitic Ivermectin on the Polychaete Species Hediste Diversicolor: Biochemical and Behavioral Responses

Nunes

Pinheiro

Gomes

2021

Preprint

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Pharmaceutical drugs have emerged as major micropollutants in aquatic ecosystems. Their presence has been systematically reported in monitoring survey, and their wide distribution and constant presence in the wild is a direct consequence of their massive use, in both human and veterinary therapeutics. Drugs used to treat parasitic infections in livestock are major contaminants, given the amounts in which they are administered, and reach the aquatic compartment in high amounts, where they may affect non target species. Some of these drugs are prone to find their final deposit in sediments of estuarine areas, exerting their toxic effects preferentially at these locations. Sediment dwelling organisms of coastal areas, such as polychaetes, are especially prone to have their major physiological functions compromised. Ivermectin is one of the most used antiparasitic drugs, and its effects are not limited to biochemical traits, but also behavioral features may be compromised considering their neurotoxic actions. Despite these putative effects, little is known about their toxicity on polychaetes. The present study aimed to characterizes the toxicity of realistic levels of ivermectin on the polychaete Nereis diversicolor, in biochemical and behavioral terms. The obtained results showed that low levels of ivermectin are capable of causing significant disturbances in mobility and burrowing activity of exposed worms, as well as alterations of metabolic and anti-oxidant defense efficacy of exposed animals, suggesting that its environment presence may mean a major environmental concern.

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“…Nanotechnology is currently considered a novel approach in diverse fields of research and also has potential for the development of improved insecticide formulations with small particle sizes ranging from 50 to 200 nm (Tadros et al, 2004). Thus, by applying nanotechnology tools, it is possible to develop pesticides with nanoemulsions and nanopowder (Athanassiou et al, 2018;Cui et al, 2018). Nanoemulsions are oil-in-water dispersions composed of small lipid droplets in the range of 50-300 nm, achieving protection of active ingredients while enhancing stability or reducing isolation of components and decreasing volatility (Huang et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Primary Screening of German Chamomile Oil as Insecticides, Baits, and Fumigants in Nanoformulations against the Health Pest Periplaneta americana (L.) (Dictyoptera: Blattidae)

El–KHODARY¹,

Ghanem²,

Rakha³

et al. 2020

Journal of the Faculty of Agriculture, Kyushu University

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Cockroaches are household pests with a health risk to humans. Natural products may have insecticidal activities against pest insects and thus inspire the development of novel insecticides as "biopesticides". In this study, we report a strategy to prepare nanoparticles of German chamomile (Matricaria chamomilla L.) oils (= essential oils or EO) to control the American cockroach in the two forms: one is coated with polyethylene glycol (PEG) as nanocapsiolation (NC) and the other is loaded with oil as a nanoemulsion (NE). First, the nanoformulations were prepared and characterized by evaluating droplet size, zeta potential, polyspersion index and morphology. The compounds of EO were also analyzed by Gas Chromatography-Mass Spectrometry (GC-MS). A complete FTIR characterization was made to confirm the formation of EO-PEG composite. In a fumigant bioassay, EO and NE caused 100% and 44.44% mortality of cockroaches at 10 mg/ liter after 1 h and 72 h of application, respectively. In a dusting toxicity bioassay, NC caused 100% mortality at 1.5 mg/500 ml after 24 h. Overall, the obtained results suggested that the oil-based nanoformulations could serve as an alternative method for producing biopesticides to overcome the disadvantage of the natural and semisynthetic pesticides and to increase their efficacy to control cockroaches. In addition, the PEG improved the stability of oil products and increased their dispersion in the aqueous phase. Although we found the essential oils of German chamomile could be useful to control the cockroaches, the techniques should be improved the nanoformulations to obtain practical effectiveness.

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Characterization and evaluation of avermectin solid nanodispersion prepared by microprecipitation and lyophilisation techniques

Cited by 20 publications

References 44 publications

Improving abamectin bioavailability via nanosuspension constructed by wet milling technique

Improving abamectin bioavailability via nanosuspension constructed by wet milling technique

Effect of Sublethal Concentrations of the Antiparasitic Ivermectin on the Polychaete Species Hediste Diversicolor: Biochemical and Behavioral Responses

Primary Screening of German Chamomile Oil as Insecticides, Baits, and Fumigants in Nanoformulations against the Health Pest Periplaneta americana (L.) (Dictyoptera: Blattidae)

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