Characterization and evaluation of solid self-microemulsifying drug delivery systems with porous carriers as systems for improved carbamazepine release

Milović, Mladen; Djuriš, Jelena; Djekić, Ljiljana; Vasiljević, Dragana; Ibrić, Svetlana

doi:10.1016/j.ijpharm.2012.06.032

Cited by 91 publications

(42 citation statements)

References 35 publications

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“…The solid-state is commonly characterized using differential scanning calorimetry (DSC) (Balakrishnan et al, 2009;Craig, 2006;Kang et al, 2012) or XRay powder diffraction (XRPD) (Docoslis et al, 2007;Hu et al, 2012;Wei et al, 2012) or vibrational spectroscopy (Milović et al, 2012;Nazzal et al, 2002;Stillhart and Kuentz, 2012). However these techniques are costly and require a highly trained user (for XRPD) and are destructive (for DSC).…”

Section: Introductionmentioning

confidence: 99%

Thorough characterization of a Self-Emulsifying Drug Delivery System with Raman hyperspectral imaging: A case study

Sacré

Netchacovitch

Bleye

et al. 2015

International Journal of Pharmaceutics

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Newly developed drugs often have poor bioavailability due to their poor water solubility (BCS class 2 drugs). It is therefore necessary to develop new strategies to enhance their solubility and their activity, among which, Self-Emulsifying Drug Delivery System (SEDDS).The efficacy of the drugs contained in these preparations is mainly affected by the solid state and the particle size of the active pharmaceutical ingredient (API).However, it is quite complex, long and expensive to characterize these parameters with classical techniques such as X-Ray powder diffraction, differential scanning calorimetry or hot stage microscopy.The present article presents, through a case study, the advantages of the Raman hyperspectral imaging in the characterization of such formulations. Indeed, Raman chemical imaging may fully characterize SEDDS with single equipment and operator in a non-destructive way allowing the follow-up of the formulation during stability studies. Raman imaging is therefore a tool of choice in the PAT framework since it increases the knowledge of the formulation and the process. 2A quantitative multivariate method using Raman hyperspectral imaging to assay the API in the lipid based formulation has been developed and fully validated following the "total error" approach.

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Section: Introductionmentioning

confidence: 99%

Thorough characterization of a Self-Emulsifying Drug Delivery System with Raman hyperspectral imaging: A case study

Sacré

Netchacovitch

Bleye

et al. 2015

International Journal of Pharmaceutics

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“…Some drugs like ibuprofen [17], naproxen [18], carbamazepine [19], and fenofibrate [20], among others, have been adsorbed on ordered silica structures, such as MCM-41 and SBA-15. Ordered mesoporous silica can control the drugs kinetic release according to excipients of continuous and controlled release.…”

Section: Mesoporous Silica As Drug Deliverymentioning

confidence: 99%

Silica from Rice as New Drug Delivery Systems

Salazar-Hernández¹,

Salazar-Hernández²,

Rocío³

et al. 2017

Rice - Technology and Production

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The pharmaceutical industry has seen an increased need of carriers or excipients design that allows the controlled release of a drug in the human body. The main role of an excipient is to carry the drug for its administration under therapeutic index. Among the new generation of excipients, the ordered mesoporous silica (MS) presents several advantages, such as excellent biocompatibility, good adsorption capacity, and precise control in the drug delivery. However, the high cost of synthesis of mesoporous silica restricts its use to industrial applications; therefore, a low-cost procedure is necessary for widespread use. Biogenic silica from rice husk (SiO 2 -rice) could be a new choice as a drug delivery system. This silica is obtained from an acid leaching of rice husk followed by calcinations processes at low temperatures; these conditions produce silica with good adsorption properties, similar to those of MS. In consequence, the excipient behavior of SiO 2 -rice was assessed using folic acid as the model drug, displaying an 18.5% of absorption in the SiO 2 -rice pores, while MS absorbed around 19%. The drug release profiles were similar for both the silicas, suggesting that SiO 2 -rice could be a low-cost, similar yield excipient for drugs similar to folic acid.

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“…Navedeni nosači se danas intenzivno istražuju zbog prihvatljivih bioloških i toksikoloških osobina, ali pre svega zbog velike specifične površine i potencijalne mogućnosti za povećanje brzine rastvaranja nisko rastvorljivih lekovitih supstanci, kao i zbog mogućnosti za adsorbovanje velike količine tečnih lipidnih formulacija (2,44). Prilikom adsorpcije lekovite supstance na različite tipove Neusilin ® nosača dolazi do stvaranja vodoničnih veza između silanolnih grupa nosača i različitih protondonorskih grupa lekovite supstance.…”

Section: Tabela II Karakteristike Najčešće Ispitivanih Sintetskih Mezunclassified

“…Pokazano je da se interakcija putem nastajanja vodoničnih veza između ibuprofena i Neusilin ® -a US2 ostvaruje čak i pri jednostavnom mešanju komponenti u tarioniku sa pistilom prilikom čega nastaje amorfni ibuprofen (62). Isti fenomen je primećen prilikom mešanja ovih nosača sa karbamazepinom u tarioniku sa pistilom što je uzrok znatno veće brzine rastvaranja karbamazepina iz fizičkih smeša u odnosu na čistu supstancu (44). Pokazano je stvaranje amorfnog oblika lekovitih supstanci ketoprofena, naproksena i indometacina vodoničnim vezama, pri usitnjavanju lekovite supstance sa Neusilin ® -om US2 u mlinu, ali i progesterona kod koga amorfni oblik nastaje drugim mehanizmom jer supstanca nema proton-donorsku grupu (8).…”

Section: Tabela II Karakteristike Najčešće Ispitivanih Sintetskih Mezunclassified

Properties and potential application of modern adsorbents in formulation of solid drug delivery systems

Krstić¹,

Milović²,

Ibrić³

2016

Arh farmaciju

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Poslednjih godina veliki broj adsorpcionih nosača prirodnog i sintetskog porekla privlači sve više pažnje zbog svoje biokompatibilnosti, prihvatljivih ekoloških i toksikoloških osobina, velike mogućnosti za modifikaciju fizičkohemijskih osobina, jednostavnog dobijanja, visoke stabilnosti i relativno niske cene. Ovi nosači su slične hemijske strukture, najčešće na bazi silicijum-dioksida, magnezijum-aluminometasilikata i kalcijum-fosfata, a međusobno se razlikuju po poroznosti struktura, specifičnoj površini, veličini, zapremini i obliku pora kao i mogućnosti funkcionalizacije površine. Uređeni mezoporozni materijali kao što su MCM -41 i SBA -15, kao i porozni materijali iz grupe Neusilin ® -a i Sylysia ® -a predstavljaju najčešće ispitivane adsorbente sa ciljem da povećaju brzinu rastvaranja lekovite supstance, a samim tim i biološku raspoloživost, ali se koriste i u formulaciji preparata sa modifikovanim ili ciljanim oslobađanjem lekovite supstance u određeno tkivo. Takođe prirodni silika materijal jedinstvenih karakteristika, izolovan iz dijatomita, dijatomitne mikrokapsule, predstavlja relativno jeftin adsorbent za formulaciju nosača za peroralnu primenu lekovite supstance kao i primenu u obliku implanta. Savremeni adsorbenti najčešće se koriste u izradi čvrstih disperzija sa nisko rastvorljivom lekovitom supstancom, ili kao adsorbenti za različite lipidne formulacije. Jedna od mogućnosti primene savremenih nosača koja se poslednjih godina ispituje jeste i funkcionalizacija površine poroznih materijala u cilju postizanja usporenog ili signalinicirajućeg oslobađanja lekovite supstance.

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Characterization and evaluation of solid self-microemulsifying drug delivery systems with porous carriers as systems for improved carbamazepine release

Cited by 91 publications

References 35 publications

Thorough characterization of a Self-Emulsifying Drug Delivery System with Raman hyperspectral imaging: A case study

Thorough characterization of a Self-Emulsifying Drug Delivery System with Raman hyperspectral imaging: A case study

Silica from Rice as New Drug Delivery Systems

Properties and potential application of modern adsorbents in formulation of solid drug delivery systems

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