Characterization and Immunological Activities of Polysaccharides from &lt;i&gt;Polygonatum sibiricum&lt;/i&gt;

Chen, Zhangbao; Liu, Jiao-Jiao; Kong, Xiangzhi; Li, Hui

doi:10.1248/bpb.b19-00978

Cited by 45 publications

(26 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The constituents of P. sibiricum include polysaccharides, saponins, flavonoids, alkaloids, lignin, vitamins, and a variety of trace elements, of which polysaccharides are the major pharmacologically active ingredients [ 20 ]. In the last three years, Polygonatum sibiricum polysaccharides (PSP) are demonstrated to exhibit a wide range of pharmacological activity [ 21 ], such as osteogenic activity [ 22 ], anti-diabetes [ 23 ], immunological activity [ 24 ], and especially antioxidant activity, which makes them suitable for application in functional foods and therapeutic agents. PSP demonstrated strong antioxidant properties, which could attenuate D-gal-induced heart aging [ 25 ] and protect the mice livers against ethanol-induced oxidative damage via inhibiting oxidative stress [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Construction of Polygonatum sibiricum Polysaccharide Functionalized Selenium Nanoparticles for the Enhancement of Stability and Antioxidant Activity

2022

View full text Add to dashboard Cite

Although selenium nanoparticles (SeNPs) have attracted great attention due to their potential antioxidant activity and low toxicity, the application of SeNPs is still restricted by their poor stability. A combination of polysaccharides and SeNPs is an effective strategy to overcome the limitations. In this study, Polygonatum sibiricum polysaccharide (PSP) was used as a stabilizer to fabricate SeNPs under a simple redox system. Dynamic light scattering, transmission electron microscopy, energy dispersive X-ray, ultraviolet-visible spectroscopy, Fourier transform infrared, and X-ray photoelectron spectrometer were applied to characterize the synthesized PSP-SeNPs. The stability and the antioxidant activity of PSP-SeNPs were also investigated. The results revealed that the zero-valent and well-dispersed spherical PSP-SeNPs with an average size of 105 nm and a negative ζ-potential of −34.9 mV were successfully synthesized using 0.1 mg/mL PSP as a stabilizer. The prepared PSP-SeNPs were stable for 30 days at 4 °C. The decoration of the nanoparticle surface with PSP significantly improved the free radical scavenging ability of SeNPs. Compared to the H2O2-induced oxidative stress model group, the viability of PC-12 cells pretreated with 20 μg/mL PSP-SeNPs increased from 56% to 98%. Moreover, PSP-SeNPs exhibited a higher protective effect on the H2O2-induced oxidative damage on PC-12 cells and lower cytotoxicity than sodium selenite and SeNPs. In summary, these results suggest the great potential of PSP-SeNPs as a novel antioxidant agent in the food or nutraceuticals area.

show abstract

Section: Introductionmentioning

confidence: 99%

Construction of Polygonatum sibiricum Polysaccharide Functionalized Selenium Nanoparticles for the Enhancement of Stability and Antioxidant Activity

2022

View full text Add to dashboard Cite

show abstract

“…The peaks near 1024 cm − 1 were due to C-O-C stretching vibrations [ 19 ]. The absorption at 820 cm − 1 suggested the presence of α-configurations [ 20 ]. The FT-IR spectra of the four PGs displayed similar characteristics, indicating that the different extraction methods did not influence the type of glycosidic bonds and polysaccharide conformations [ 21 ].…”

Section: Resultsmentioning

confidence: 99%

Comparative Characterization and Immunomodulatory Activities of Polysaccharides Extracted from the Radix of Platycodon grandiflorum with Different Extraction Methods

et al. 2022

View full text Add to dashboard Cite

Platycodon grandiflorum is an edible and medicinal plant, and polysaccharides are one of its important components. To further improve the utilization rate of P. grandiflorum, we investigated the effects of four different extraction methods, including hot water, ultrasonic-assisted, acid-assisted, and alkali-assisted extractions, on the polysaccharides, which were named PG-H, PG-U, PG-C, and PG-A. The findings indicated that the extraction method had a significant impact on the yield, characteristics, and immunoregulatory activity. We observed that the yields decreased in the following order: PG-H, PG-U, PG-C, and PG-A. Galacturonic acid, glucose, galactose, and arabinose were the most prevalent monosaccharides in the four PGs. However, their proportions varied. In addition, the difference between the content of glucose and galacturonic acid was more significant. PG-U had the highest glucose content, whereas PG-C had the lowest. Galacturonic acid content was highest in PG-A, while the lowest in PG-U. The molecular weight decreased in the order of PG-U, PG-H, PG-C, and PG-A; the particle size was in the order of PG-U, PG-A, PG-H, and PG-C. Moreover, the extraction method had a great impact on immunoregulatory activity. The ability to stimulate the immune function of macrophages was as follows: PG-A > PG-C > PG-U > PG-H. The results indicated that PGs, with lower molecular weights and higher GalA content, exhibited better immune-stimulating activity. And more important the AAE method was a good way to extract polysaccharides from Platycodon grandiflorum for use as a functional product and immunological adjuvant.

show abstract

“…Chen et al. ( 121 ) studied the immunomodulatory activity of Polygonatum sibiricum polysaccharide (PSP) and elucidated its underlying mechanism of action by monitoring changes in immune organs, immune cells, and cytokines. Experimental results showed that PSP not only enhanced immune function of normal mice, but also participated in immunosuppressive protection of Cy-treated mice, which suggested its potential as an immunostimulant.…”

Section: Nano Drug Delivery System For Tumor Immunotherapymentioning

confidence: 99%

Nano Drug Delivery System for Tumor Immunotherapy: Next-Generation Therapeutics

Zhou

Zou

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

Tumor immunotherapy is an artificial stimulation of the immune system to enhance anti-cancer response. It has become a powerful clinical strategy for treating cancer. The number of immunotherapy drug approvals has been increasing in recent years, and many treatments are in clinical and preclinical stages. Despite this progress, the special tumor heterogeneity and immunosuppressive microenvironment of solid tumors made immunotherapy in the majority of cancer cases difficult. Therefore, understanding how to improve the intratumoral enrichment degree and the response rate of various immunotherapy drugs is key to improve efficacy and control adverse reactions. With the development of materials science and nanotechnology, advanced biomaterials such as nanoparticle and drug delivery systems like T-cell delivery therapy can improve effectiveness of immunotherapy while reducing the toxic side effects on non-target cells, which offers innovative ideas for improving immunity therapeutic effectiveness. In this review, we discuss the mechanism of tumor cell immune escape and focus on current immunotherapy (such as cytokine immunotherapy, therapeutic monoclonal antibody immunotherapy, PD-1/PD-L1 therapy, CAR-T therapy, tumor vaccine, oncolytic virus, and other new types of immunity) and its challenges as well as the latest nanotechnology (such as bionic nanoparticles, self-assembled nanoparticles, deformable nanoparticles, photothermal effect nanoparticles, stimuli-responsive nanoparticles, and other types) applications in cancer immunotherapy.

show abstract

Characterization and Immunological Activities of Polysaccharides from <i>Polygonatum sibiricum</i>

Cited by 45 publications

References 29 publications

Construction of Polygonatum sibiricum Polysaccharide Functionalized Selenium Nanoparticles for the Enhancement of Stability and Antioxidant Activity

Construction of Polygonatum sibiricum Polysaccharide Functionalized Selenium Nanoparticles for the Enhancement of Stability and Antioxidant Activity

Comparative Characterization and Immunomodulatory Activities of Polysaccharides Extracted from the Radix of Platycodon grandiflorum with Different Extraction Methods

Nano Drug Delivery System for Tumor Immunotherapy: Next-Generation Therapeutics

Contact Info

Product

Resources

About