Characterization and Immunological Evaluation of Chitosan Nanoparticles as Adjuvants for Bovine Coronavirus N Protein

Sun, Qian; Zhang, Jia Ling; Han, De Quan; Yang, Yanfei; Zhu, Li; Yu, Li

doi:10.4028/www.scientific.net/amm.161.113

Cited by 5 publications

(4 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The IgM content in serum increased after the second immunization in the BCV N protein-loaded CNP group. These findings indicate that CNP can be used as a novel adjuvant in veterinary vaccine field [ 130 ].…”

Section: Antiviral Nanomaterials and Delivery Systems Of Polysaccharimentioning

confidence: 99%

Application prospect of polysaccharides in the development of anti-novel coronavirus drugs and vaccines

Chen¹,

Han²,

Wang

2020

International Journal of Biological Macromolecules

136

113

View full text Add to dashboard Cite

Since the outbreak of the novel coronavirus disease COVID-19, caused by the SARS-CoV-2 virus, it has spread rapidly worldwide and poses a great threat to public health. This is the third serious coronavirus outbreak in <20 years, following SARS in 2002–2003 and MERS in 2012. So far, there are almost no specific clinically effective drugs and vaccines available for COVID-19. Polysaccharides with good safety, immune regulation and antiviral activity have broad application prospects in anti-virus, especially in anti-coronavirus applications. Here, we reviewed the antiviral mechanisms of some polysaccharides, such as glycosaminoglycans, marine polysaccharides, traditional Chinese medicine polysaccharides, and their application progress in anti-coronavirus. In particular, the application prospects of polysaccharide-based vaccine adjuvants, nanomaterials and drug delivery systems in the fight against novel coronavirus were also analyzed and summarized. Additionally, we speculate the possible mechanisms of polysaccharides anti-SARS-CoV-2, and propose the strategy of loading S or N protein from coronavirus onto polysaccharide capped gold nanoparticles vaccine for COVID-19 treatment. This review may provide a new approach for the development of COVID-19 therapeutic agents and vaccines.

show abstract

Section: Antiviral Nanomaterials and Delivery Systems Of Polysaccharimentioning

confidence: 99%

Application prospect of polysaccharides in the development of anti-novel coronavirus drugs and vaccines

Chen¹,

Han²,

Wang

2020

International Journal of Biological Macromolecules

136

113

View full text Add to dashboard Cite

show abstract

“…Furthermore, high concentrations of AgNPs immobilized in CNFS could significantly reduce the virus in logs of 10 CFU/ml, while CNFS provided a minor reduction in influenza A viruses. In addition, Sun et al (2012) investigated the use of chitosan nanoparticles loaded with nucleocapsid proteins from bovine coronavinis (BCV N). This process used the ionic crosslinking method with sodium tripolyphosphate as a crosslinking agent.…”

Section: Antiviral Chitin/chitosan Nanofiber Mask Against Covid-19mentioning

confidence: 99%

Production of Cellulose and Chitin Nanofibers Based Masks for Protecting Against Corona Virus: A Review

Fahma

Firmanda²,

Widiastuti³

et al. 2022

JART

View full text Add to dashboard Cite

The corona virus or SARS-CoV2 is a pathogenic virus that has become a pandemic and a threat in almost all countries in the world. SARS-CoV2 belongs to the Coronaviridae family with particle sizes varying around 60 nm - 140 nm. Various regulations and prevention have been designed to reduce the impact of Covid-19 by SARS-CoV2. Several technologies and studies have been developed to form nanofiber woven membranes. Cellulose nanofibers and chitin/chitosan nanofibers have been studied and are known to have nanometer-sized structures smaller than SARS-CoV2. Chitin/chitosan has been investigated to have antiviral properties, especially corona virus. Cellulose nanofibers, and chitin/chitosan nanofibers has the potential to be developed for Covid-19 virus nanofiltration masks. Various active agents (nanosilver, nanogold, CuO, etc.) have been known to have antiviral and/or antibacterial properties so that they can be used as nanofillers to enhance the performance and effectiveness of nanofibers based masks against SARS-CoV2.

show abstract

“…Such a difference could be due to the low dosage of bare or nanoencapsulated DNA. In a study, Sun et al showed that intramuscular administration of chitosan-encapsulated N protein of bovine CoV (BCV N) NPs can significantly enhance IgA and IgG levels as compared to Montanide ISA 206, an oil adjuvant, effectiveness of chitosan NPs to be used as an adjuvant for BCV N protein [147]. Altogether, nanotechnology-based vaccine formulations are promising immune cell activators and antigen carriers for vaccination, but further studies are still required.…”

Section: Convalescent Plasmamentioning

confidence: 99%

Recent Advances on Nanotechnology-Based Strategies for Prevention, Diagnosis, and Treatment of Coronavirus Infections

Alimardani

Abolmaali

Tamaddon

2021

Journal of Nanomaterials

View full text Add to dashboard Cite

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is exponentially spreading across the world, leading to an outbreak of serious viral pneumonia. Antiviral therapies using chloroquine, hydroxychloroquine, and favipiravir have been approved by several countries to increase the quality of life of SARS-CoV-2-infected patients. Currently, several companies are intensively working on the production of coronavirus (CoV) vaccines, resulting in some specific vaccines that have been approved for CoV infections in humans. Nevertheless, efficient and specific prevention, treatment, and diagnosis are urgently required to combat the biological diversity and rapid mutation in CoV infections. Recently, significant attention has devoted to nanoformulation or nanoparticles (NPs) due to their specific features like high surface-to-volume ratio, drug encapsulation abilities, and specific optical properties to remove the complications of applied conventional therapeutic and diagnosis options. In this regard, NPs are increasingly used as new anti-CoV agents, vaccine carriers or adjuvants, and nanoscale biorecognition elements. The present review article provides a comprehensive discussion on the recent updates regarding the prevention, diagnosis, and treatment of different CoV infections with an emphasis on the application of NPs in vaccination, treatment, and diagnosis of CoV infections.

show abstract

Characterization and Immunological Evaluation of Chitosan Nanoparticles as Adjuvants for Bovine Coronavirus N Protein

Cited by 5 publications

References 22 publications

Application prospect of polysaccharides in the development of anti-novel coronavirus drugs and vaccines

Application prospect of polysaccharides in the development of anti-novel coronavirus drugs and vaccines

Production of Cellulose and Chitin Nanofibers Based Masks for Protecting Against Corona Virus: A Review

Recent Advances on Nanotechnology-Based Strategies for Prevention, Diagnosis, and Treatment of Coronavirus Infections

Contact Info

Product

Resources

About