Characterization and inhibitory effect of antibacterial dental resin composites incorporating silver-supported materials

Abstract

Resin composites with antibacterial activity may be useful for preventing the secondary caries frequently seen around restorations. The purposes of this study were to investigate antibacterial light-activated dental resin composites incorporating each of two silver-supported antibacterial materials and evaluate their long-lasting inhibitory effect against Streptococcus mutans. Two types of silver-supported antibacterial materials, Novaron (N) and Amenitop (AM) were used. These antibacterial materials were incorporated into TEGDMA-UDMA-based light-activated resin composites, and the antibacterial activities and mechanical properties of these composites, and also the release of silver ions, were examined. Two silver-supported antibacterial materials inhibited the growth of the major oral pathogen S. mutans. The minimum inhibitory concentration in suspensions of N and AM against S. mutans was 40 microg/mL and 30 microg/mL, respectively. Composites incorporating 5 wt % (N-5) or more of Novaron and 7 wt % (AM-7) or more of Amenitop inhibited the growth of S. mutans after immersion in water for 6 months. There was no or extremely little release of silver ions from the N-5 and AM-7 composites after 1 day or after 6 months of immersion in water. No significant difference in either compressive or flexural strength was observed between the control and the N-5 composites after 1 day or after 6 months of storage in water. However, for the AM-5 composite, there was a significant difference in both strength parameters between the two immersion periods. These results indicate that a light-activated dental resin composite incorporating silver-supported antibacterial material such as Novaron may be useful clinically because of its long-lasting inhibitory effect against S. mutans and its favorable mechanical properties.

Addition of silver nanoparticles reduces the wettability of methacrylate and silorane-based composites

“…Previous studies have reported silver compounds added at 10% or greater to dental materials would significantly reduce compressive strength, elastic modulus, and tensile strength. 11,15 Therefore, it seems that nano particles added in low concentrations, as in the present study, would not adversely affect the mechanical properties of composite resins. Discoloration and a change in color to a tone of gray are common problems in all materials containing silver, especially composite resins.…”

The Antibacterial Properties of Composite Resin Containing Nanosilver against Streptococcus mutans and Lactobacillus

“…15,25,26 Hernández-Sierra et al 27 evaluated the sensitivity of Streptococcus mutans to nano particles of silver (25 nm), zinc oxide (125 nm) and gold (80 nm) and indicated the higher antibacterial properties of nano silver than nano zinc oxide and nanogold; they attributed this results to smaller particle size of nanosilver than nano zinc oxide particles. Concerns exist about the adverse effect of nanoparticle additives on the mechanical properties of composite resins; however, previous studies have reported silver compounds added in 10% concentration or greater to dental materials would significantly reduce compressive strength, elastic modulus and tensile strength.…”

pH-responsive release of chlorhexidine from modified nanoporous silica nanoparticles for dental applications

“…For efficient prevention or treatment of biofilm infections several systems releasing antibacterial and remineralizing agents have been reported, e.g. fluoride (F − ) [3][4][5][6], calcium (Ca 2+ ) and phosphate (PO 4 3− ) [7][8][9][10] or silver (Ag + ) ions [11,12]. Chlorhexidine (CHX) is a widely applied drug because of its high antimicrobial activity against gram-positive and gram-negative bacteria, fungi and viruses [13].…”