Characterization and modulation of brain lipids content of rainbow trout fed with 100% plant based diet rich in omega-3 long chain polyunsaturated fatty acids DHA and EPA

Roy, Jérôme; Vigor, Claire; Vercauteren, Joseph; Réversat, Guillaume; Zhou, Bingqing; Surget, Anne; Larroquet, Laurence; Lanuque, Anthony; Sandres, Franck; Terrier, Frédéric; Oger, Camille; Galano, Jean‐Marie; Corraze, Généviève

doi:10.1016/j.biochi.2020.06.010

Cited by 16 publications

(13 citation statements)

References 73 publications

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“…Rainbow trout are the most widely utilized fish for assessing the acute toxicity of effluents. For AA and DHA, in rainbow trout, the fatal concentrations generating a 50% death rate in 96 hours (LC 50 /96 h) were 0.7-1.5 and 0.8-1.7 mL, respectively (Gregory & James, 2014;Wu et al, 2020), while in Daphnia Magna, the LC 50 /48 h values were 2.5-6.4 and 19.2 mg/L, respectively (Roy et al, 2020). Furthermore, allergic effects have been documented for AA and DHA.…”

Section: Discussionmentioning

confidence: 99%

Safety assessment of antimicrobials in food packaging paper based on LC-MS method

et al. 2022

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Many difficulties relating to food safety have been solved thanks to the employment of strong mass spectrometric detectors in conjunction with liquid chromatography. In this study, samples were fractionated using gel permeation chromatography and liquid/liquid extraction, and liquid chromatography/mass spectrometry (LC/MS) and gas chromatography/mass spectrometry were used to detect possible genotoxicant(s) in recycled paperboard. As a genotoxicity indicator, the rec-assay was utilized. Abietic acid (AA) and dehydroabietic acid (DHA) and were discovered in the recycled paperboard to be genotoxic. AA and DHA were found in 2 of 5 virgin products and all seven recycled food-contact products. AA and DHA total levels in virgin goods were 990 and 240 mg/g, respectively, whereas recycled products had 200990 mg/g. The total quantity of AA and DHA content in DNA-damaging activity and paper products were shown to have a strong connection. Furthermore, genotoxic effects in paper products matched standard chemicals well, showing that AA and DHA were primarily responsible for the genotoxic effects of these paper products.

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Section: Discussionmentioning

confidence: 99%

Safety assessment of antimicrobials in food packaging paper based on LC-MS method

et al. 2022

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“…Under voluntary FI, we reported that fish could distinguish between diets containing different levels of ω-3 LC-PUFA and exhibit a preference for diets containing high levels of EPA and DHA. Furthermore, we observed that a diet rich in ω-3 LC-PUFA accounted for a relatively high proportion of brain function [11] and brain lipid content [12] in RT juveniles. These recent studies have disclosed implications of ω-3 LC-PUFA on the modulation and regulation on the control of FI particularly the fatty acid (FA) sensing pathways even though molecular pathways remain to be elucidated.…”

Section: Introductionmentioning

confidence: 74%

“…Nutrient compositions of the diets were analyzed by drying the samples to constant weight at 105 °C for 24 h. Crude protein was determined by the Kjeldahl method after acid digestion and the concentration was estimated by multiplying the nitrogen content using the 6.25 factor as commonly used [32]. Crude lipids were quantified by the Soxhlet method using petroleum diethyl ether for the extraction as previously described [12]. Gross energy was determined with an adiabatic bomb calorimeter (IKA, Heitersheim Gribheimer, Germany).…”

Section: Proximate Compositionmentioning

confidence: 99%

Involvement of Taste Receptors in the Oro-Sensory Perception of Nutrients in Rainbow Trout (Oncorhynchus mykiss) Fed Diets with Different Fatty Acid Profiles

Roy

Baranek

Mercier

et al. 2022

Aquaculture Nutrition

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Taste perception plays an important role in an animal’s detection of nutrients, conveying key dietary information, fundamental for its growth and survival. Because alternative terrestrial ingredients are known to affect the feeding of rainbow trout (RT, Oncorhynchus mikyss), we aimed to assess the importance of taste receptors in detection. Using self-feeders, we examined the feeding behavior (30 days of a feeding trial followed by 10 days of a preference trial) of RT fed with a commercial diet (C), vegetable diets supplemented with linseed oil (V1) or algal oil (V2). During the feeding trial those fed V2 decreased their food intake. The preference trial revealed that fish preferred V2 v. C and V1 v. V2 for fish which had consumed V1 and C during their feeding trial. Mechanistically, taste receptors were mainly expressed in taste organs and regulated by diet, which indicated the function of the taste receptors. Some taste receptors for fatty acids (such as the ffar receptor) and amino acids (such as the tasr receptor) were highly expressed in the RT tongue. While ffar2a transcripts were upregulated by vegetal diets in the tongue, ffar1 and ffar4, known for important roles in mammals, were very low expressed and not found in the RT genome, respectively. Overall findings show that RT displayed the fundamental mechanisms for oro-gustatory perception of nutrients related to different diet composition.

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“…As noted above, nutritional regulation of both fads2 and elovl2 but not elovl5 was observed, with increased expression of those genes in brain of fish fed the VO diets. These results indicate that tambaqui is, to some extent, able to guarantee the high DHA demand in brain when fed on diets containing suboptimal levels of this essential nutrient (Roy et al, 2020). Consistently, our study on the functional characterization of LC‐PUFA biosynthesizing enzymes in tambaqui demonstrated that both elovl2 and fads2 play key roles in the biosynthesis of DHA (Ferraz et al, 2019).…”

Section: Discussionmentioning

confidence: 91%

Regulation of gene expression associated with LC‐PUFA metabolism in juvenile tambaqui ( Colossoma macropomum ) fed different dietary oil sources

Ferraz

Modesto

Cunha

et al. 2021

Aquaculture Research

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Given the ecological unsustainability of using fish oil (FO) as the main source of longchain polyunsaturated fatty acids (LC-PUFA), the investigation of alternative dietary LC-PUFA sources is crucial for aquaculture. Tambaqui (Colossoma macropomum) is a valuable economic aquaculture resource in Brazil, capable of endogenously elongating and desaturating linoleic (LA; 18:2n-6) and α-linolenic (ALA; 18:3n-3) acids to longer and physiologically vital LC-PUFA. Yet, it is unclear how this pathway is regulated by different oil sources in tambaqui. Thus, we designed an experiment with 2 different oil diets (fish oil-FO and vegetable oil-VO) at 2 different concentrations (5% or 10%) to investigate the molecular regulation of fatty acid biosynthesis in this species. We observed no differences in survival, body weight gain (BWG) and feed conversion ratio between the treatments. Gene expression analysis shows that fads2 and elovl5 are upregulated in liver, while fads2 and elovl2 are up-regulated in brain of tambaqui fed with VO. The transcription factors pparβb and pparγ are also up-regulated in the brain by VO diet, when compared to FO diet. The VO diet also contributed to the biosynthesis of LC-PUFA in liver and specifically DHA in the brain. Overall, our approach shows that lipid metabolism-relevant genes are regulated by different dietary lipid sources.

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Characterization and modulation of brain lipids content of rainbow trout fed with 100% plant based diet rich in omega-3 long chain polyunsaturated fatty acids DHA and EPA

Cited by 16 publications

References 73 publications

Safety assessment of antimicrobials in food packaging paper based on LC-MS method

Safety assessment of antimicrobials in food packaging paper based on LC-MS method

Involvement of Taste Receptors in the Oro-Sensory Perception of Nutrients in Rainbow Trout (Oncorhynchus mykiss) Fed Diets with Different Fatty Acid Profiles

Regulation of gene expression associated with LC‐PUFA metabolism in juvenile tambaqui ( Colossoma macropomum ) fed different dietary oil sources

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