Characterization and optimization of novel surface-enhanced Raman scattering (SERS)-based nanoimaging probes for chemical imaging

Hankus, Mikella E.; Gibson, Gregory J.; Cullum, Brian M.

doi:10.1117/12.629098

Cited by 9 publications

(5 citation statements)

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“…30,31 The A-chains of ricin and abrin share 40% sequence identity, including the enzymatic active site, while the B-chains share 60% sequence homology. 32,33 The similarity in their structures is evident in the overlay of their crystal structures shown in Figure 2. Modified derivatives of both of these proteins exist with significant reduction of toxicity and were used in this study, namely RiVax and abrax.…”

Section: Peptide-based Sensingmentioning

confidence: 76%

“…It is suggested that the reader look to several comprehensive reviews and interesting papers for a more complete discussion of SERS substrate fabrication techniques, applications, advantages and challenges. 1,[28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47] One of the more common and easily achieved methods for the fabrication of SERS substrates is known as the drop and dry technique. Drop and dry techniques or Film over Nanosphere (FONS) offer some advantages as compared to other fabrication methods like ease of fabrication due to cheaper manufacturing materials, and often being lower cost in skill, time and overall materials as compared to some other more fabrication intensive techniques.…”

Section: Example Sers Substratesmentioning

confidence: 99%

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The development of Army relevant peptide-based surface enhanced Raman scattering (SERS) sensors for biological threat detection

et al. 2016

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The utility of peptide-based molecular sensing for the development of novel biosensors has resulted in a significant increase in their development and usage for sensing targets like chemical, biological, energetic and toxic materials. Using peptides as a molecular recognition element is particularly advantageous because there are several mature peptide synthesis protocols that already exist, peptide structures can be tailored, selected and manipulated to be highly discerning towards desired targets, peptides can be modified to be very stable in a host of environments and stable under many different conditions, and through the development of bifunctionalized peptides can be synthesized to also bind onto desired sensing platforms (various metal materials, glass, etc.). Two examples of the several Army relevant biological targets for peptide-based sensing platforms include Ricin and Abrin. Ricin and Abrin are alarming threats because both can be weaponized and there is no antidote for exposure. Combining the sensitivity of SERS with the selectivity of a bifunctional peptide allows for the emergence of dynamic hazard sensor for Army application.

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Section: Peptide-based Sensingmentioning

confidence: 76%

Section: Example Sers Substratesmentioning

confidence: 99%

The development of Army relevant peptide-based surface enhanced Raman scattering (SERS) sensors for biological threat detection

et al. 2016

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“…To provide a nanosensor/nanoprobe capable of obtaining dynamic images, a novel nanoimaging probe has been developed whereby coherent fiber optic imaging bundles were coupled with SERS for real-time subdiffraction-limited chemical imaging [68,[101][102][103][104]. This SERS nanoimaging probe has an advantage of providing both temporal and spatial resolution, thereby allowing the monitoring of the movement of macromolecules across membranes.…”

Section: Sers-based Nanoimagingmentioning

confidence: 99%

“…In proof-of-principle studies, such probes have been used for chemical differentiation of various samples with <100 nm spatial resolution [68,[101][102][103][104]. In one such study, gelatin was homogenously mixed with brilliant cresyl blue (BCB), while benzoic acid was spotted at various locations around the edge.…”

Section: Sers-based Nanoimagingmentioning

confidence: 99%

Surface-Enhanced Raman Scattering as an Emerging Characterization and Detection Technique

Çulha

Cullum

Lavrik

et al. 2012

Journal of Nanotechnology

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While surface-enhanced Raman spectroscopy (SERS) has been attracting a continuously increasing interest of scientific community since its discovery, it has enjoyed a particularly rapid growth in the last decade. Most notable recent advances in SERS include novel technological approaches to SERS substrates and innovative applications of SERS in medicine and molecular biology. While a number of excellent reviews devoted to SERS appeared in the literature over the last two decades, we will focus this paper more specifically on several promising trends that have been highlighted less frequently. In particular, we will briefly overview strategies in designing and fabricating SERS substrates using deterministic patterning and then cover most recent biological applications of SERS.

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“…Some examples of SERS substrate fabrication include self-assembly through such techniques like drop and dry, directed or templated assembly, thin film growth, and nanolithography. It is suggested that the reader look to several comprehensive reviews and interesting papers for a more complete discussion of SERS substrate fabrication techniques, applications, advantages and challenges3,11,17,24,33,84,85,[108][109][110][111][112][113][114][115][116][117][118][119][120][121] .…”

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confidence: 99%

Flexible SERS-based substrates: challenges and opportunities toward an Army relevant universal sensing platform

2015

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Generally the fabrication, assembly and evaluation of plasmonic nanostructures for surface enhanced Raman scattering (SERS) substrates has focused on static rigid substrates such as glass and silicon. However, these static substrates severely limit the application of plasmonic nanostructures as (i) they provide no means to alter the state of assembly of the nanostructures once they are formed or anchored on the surface i.e., not reconfigurable; and (ii) preclude applications which demand non-planar, flexible or conformal surfaces. The above considerations has led to the development of a novel class of SERS substrates based on flexible substrates such paper, polymer membranes and electrospun fibers. These flexible SERS media based on unconventional substrates such as paper offer distinct advantages compared to the conventional SERS substrates in that (i) flexible nature of the substrate enables conformal contact with the surfaces under investigation leading to efficient sample collection; (ii) porous nature of the SERS substrate (interstices between the fibers) provides efficient access to the analytes; (iii) high surface area of the 3D paper substrate results in large dynamic range of the chemical sensors; (iv) intricate network of fibers decorated with metal nanoparticles can provide potentially high density of electromagnetic hotspots; (v) intense light scattering caused by the fibrous structure of the substrate (e.g., paper) enables efficient light-metal interaction; and (vi) facile fabrication leads to efficient, robust, reliable, reusable and cost-effective SERS substrates. In this presentation, we will focus on the Army need for a more flexible (substrate surface and application) SERS substrate for universal sensing. This presentation will leverage from material presented at a flexible SERS (May 2014) workshop hosted by Dr. Srikanth Singamaneni at Washington University.

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Characterization and optimization of novel surface-enhanced Raman scattering (SERS)-based nanoimaging probes for chemical imaging

Cited by 9 publications

References 0 publications

The development of Army relevant peptide-based surface enhanced Raman scattering (SERS) sensors for biological threat detection

The development of Army relevant peptide-based surface enhanced Raman scattering (SERS) sensors for biological threat detection

Surface-Enhanced Raman Scattering as an Emerging Characterization and Detection Technique

Flexible SERS-based substrates: challenges and opportunities toward an Army relevant universal sensing platform

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