Characterization and Outcomes of Hospitalized Children With Coronavirus Disease 2019: A Report From a Multicenter, Viral Infection and Respiratory Illness Universal Study (Coronavirus Disease 2019) Registry

Bhalala, Utpal; Gist, Katja M.; Tripathi, Sandeep; Boman, Karen; Kumar, Vishakha; Retford, Lynn; Chiotos, Kathleen; Blatz, Allison M.; Dapul, Heda; Verma, Sourabh; Sayed, Imran; Gharpure, Varsha; Bjornstad, Erica C.; Tofil, Nancy M.; Irby, Katherine; Sanders, Ronald C.; Heneghan, Julia A.; Thomas, Melissa K.; Gupta, Manoj; Oulds, Franscene; Arteaga, Grace M.; Levy, Emily R.; Gupta, Neha; Kaufman, Margit; AbdelAty, Amr M.; Shlomovich, Mark; Medar, Shivanand; O'Meara, A M Iqbal; Kuehne, Joshua; Menon, Shina; Khandhar, Paras B.; Miller, Aaron S.; Barry, Suzanne; Danesh, Valerie; Khanna, Ashish K.; Zammit, Kimberly; Stulce, Casey; McGonagill, Patrick W.; Bercow, Asher; Amzuta, Ioana; Gupta, Sandeep; Almazyad, Mohammed; Pierre, Louisdon; Sendi, Prithvi; Ishaque, Sidra; Anderson, Harry L.; Nawathe, Pooja; Akhter, Murtaza; Lyons, Patrick G.; Chen, Catherine; Walkey, Allan J.; Bïhorac, Azra; Bello, Imam Wada; Ari, Judith Ben; Kovačević, Tanja; Bansal, Vikas; Brinton, John T.; Zimmerman, Jerry J.; Kashyap, Rahul

doi:10.1097/ccm.0000000000005232

Cited by 39 publications

(51 citation statements)

References 40 publications

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“…Although fever, cough and rhinorrhea were the most common symptoms of children with severe COVID-19, we observed that the proportion of patients with cough and rhinorrhea was significantly lower than that of other respiratory viruses. The presence of cough was only reported in around one-third of children admitted to the ICU in a previous study ( 26 ). In our study, COVID-19 results in less severe disease when compared to other respiratory viruses, evidenced by the lower proportion of patients who required ICU admission, high flow nasal cannula/non-invasive ventilation, mechanical ventilation and empirical antibiotics.…”

Section: Discussionmentioning

confidence: 88%

Comparison of Severe Viral Pneumonia Caused by SARS-CoV-2 and Other Respiratory Viruses Among Malaysian Children During the COVID-19 Pandemic

Tan

TING

et al. 2022

Front. Pediatr.

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ObjectivesWe described the etiology of severe pneumonia in children during the height of the COVID-19 pandemic in Malaysia and compared the clinical features of severe SARS-CoV-2 to other respiratory viruses.MethodsThis retrospective study included all children aged 12 years and below hospitalized with severe pneumonia in Negeri Sembilan, Malaysia, between 1 April 2021 and 31 October 2021. We extracted demographic and clinical data and used logistic regression to examine risk factors associated with severe SARS-CoV-2 or other viral pneumonia.ResultsA total of 111 children were included. The median age was 15 months. Human rhinovirus/enterovirus, SARS-CoV-2 and respiratory syncytial virus were the most common etiology of severe pneumonia. Codetection of >1 viral pathogen was present in 14 (12.6%) patients. Children with severe COVID-19 presented early in the course of illness and had lower rates of pediatric intensive care admission. The presence of sick contact with an adult was a predictor for SARS-CoV-2, whereas adventitious breath sounds were predictive of other respiratory viruses.ConclusionsThe etiology of severe pneumonia in children evolved with the epidemic curve of COVID-19 and school closures. Children with severe pneumonia due to SARS-CoV-2 experienced a milder clinical course when compared to other respiratory viruses.

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Section: Discussionmentioning

confidence: 88%

Comparison of Severe Viral Pneumonia Caused by SARS-CoV-2 and Other Respiratory Viruses Among Malaysian Children During the COVID-19 Pandemic

Tan

TING

et al. 2022

Front. Pediatr.

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“…Our study of critical paediatric COVID-19 from HICs and LMICs observed higher mortality than previously reported in large PICU studies and identified several factors associated with mortality. 4 , 6 , 7 Having a primarily respiratory illness was associated with higher mortality, while developing MIS-C or receiving treatments typically used for MIS-C was associated with lower mortality. Comorbid medical conditions were associated with higher mortality, both overall and in the subset of patients without MIS-C. Dexamethasone was not associated with improved mortality in any illness presentation or age group.…”

Section: Discussionmentioning

confidence: 99%

“… 2 , 3 Few studies focus on paediatric critical COVID-19, and most larger studies are from high-income countries (HICs). 4 , 5 , 6 , 7 Studies examining paediatric ICU (PICU) admissions from low-middle-income countries (LMICs) are scarce and generally focus on multisystem inflammatory syndrome in children (MIS-C). 8 , 9 , 10 …”

Section: Introductionmentioning

confidence: 99%

Paediatric critical COVID-19 and mortality in a multinational prospective cohort

González‐Dambrauskas

Vásquez‐Hoyos

Camporesi

et al. 2022

The Lancet Regional Health - Americas

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“…As noted earlier, the impact of comorbidities on the severity of viral respiratory infections has been at the forefront during the COVID-19 pandemic. Comorbidities associated with severe COVID-19 include asthma, neurological disease, obesity, and diabetes [ 22 ]. For example, among 3221 SARS-CoV-2-positive children and adolescents enrolled in a global prospective cohort study with outcome data, 3.3% had severe outcomes within 14 days [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

How Comorbidities Affect Hospitalization from Influenza in the Pediatric Population

Mylonakis

Mylona

Kalligeros

et al. 2022

IJERPH

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Influenza is a contagious respiratory illness and can lead to hospitalization and even death. Understanding how comorbidities affect the severity of influenza can help clinical management. The aim of this study is to offer more information about comorbidities that might be associated with the severity of influenza in children. We used a statewide network in Rhode Island, USA, to extract data for laboratory-confirmed influenza cases among children 19 years old or younger. We identified 1169 lab-confirmed influenza cases. The most common comorbidities were asthma (17.1%), neurodevelopmental disorders (10.3%), gastrointestinal disorders (7.6%), atopic dermatitis (7%), and endocrine and metabolic diseases (6.8%). Interestingly, 80.8% (63 out of 78) of children who had an influenza-related hospital admission had at least one comorbidity, and among hospitalized children with influenza, the most common comorbidities were neurological diseases (28.2%, 22/78), gastrointestinal disorders (25.6%, 20/78), endocrine and metabolic diseases (24.4%, 19/78), and neurodevelopmental disorders (23.1%, 18/78). Children with endocrine or metabolic diseases were 8.23 times more likely to be admitted to the hospital, and children with neurological disorders were 6.35 times more likely to be admitted (OR: 8.23, 95% CI: 4.42–15.32 and OR: 6.35, 95% CI: 3.60–11.24, respectively). In summary, we identified specific comorbidities associated with influenza hospitalization and length of hospital stay, and these groups should be prioritized for public health interventions.

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Characterization and Outcomes of Hospitalized Children With Coronavirus Disease 2019: A Report From a Multicenter, Viral Infection and Respiratory Illness Universal Study (Coronavirus Disease 2019) Registry

Abstract: Supplemental Digital Content is available in the text.

Cited by 39 publications

References 40 publications

Comparison of Severe Viral Pneumonia Caused by SARS-CoV-2 and Other Respiratory Viruses Among Malaysian Children During the COVID-19 Pandemic

Comparison of Severe Viral Pneumonia Caused by SARS-CoV-2 and Other Respiratory Viruses Among Malaysian Children During the COVID-19 Pandemic

Paediatric critical COVID-19 and mortality in a multinational prospective cohort

How Comorbidities Affect Hospitalization from Influenza in the Pediatric Population

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