Characterization and performances of DOSION, a dosimetry equipment dedicated to radiobiology experiments taking place at GANIL

Boissonnat, Guillaume; Fontbonne, J.M.; Balanzat, Emmanuel; Boumard, Frederic; Carniol, B.; Cassimi, A.; Colin, J.; Cussol, D.; Étasse, D.; Fontbonne, C.; Frelin, Anne-Marie; Hommet, J.; Salvador, S.

doi:10.1016/j.nima.2016.12.040

Cited by 7 publications

(6 citation statements)

References 9 publications

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“…Other approaches based on modified ionization chambers, such as the DOSION beam monitoring equipment [71], have been applied successfully in FLASH regimes [57], and may have scope for application with laser-driven sources. Several real-time approaches employing volumetric scintillation detectors [72], fibre optic dosimeters [73,74], radioluminescence and Cherenkov emission based dosimeters have also been used for conventional dose rate proton beams as well as FLASH protons.…”

Section: Diagnostics and Dosimetrymentioning

confidence: 99%

Radiobiology Experiments With Ultra-high Dose Rate Laser-Driven Protons: Methodology and State-of-the-Art

Chaudhary¹,

Milluzzo

Ahmed

et al. 2021

Front. Phys.

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The use of particle accelerators in radiotherapy has significantly changed the therapeutic outcomes for many types of solid tumours. In particular, protons are well known for sparing normal tissues and increasing the overall therapeutic index. Recent studies show that normal tissue sparing can be further enhanced through proton delivery at 100 Gy/s and above, in the so-called FLASH regime. This has generated very significant interest in assessing the biological effects of proton pulses delivered at very high dose rates. Laser-accelerated proton beams have unique temporal emission properties, which can be exploited to deliver Gy level doses in single or multiple pulses at dose rates exceeding by many orders of magnitude those currently used in FLASH approaches. An extensive investigation of the radiobiology of laser-driven protons is therefore not only necessary for future clinical application, but also offers the opportunity of accessing yet untested regimes of radiobiology. This paper provides an updated review of the recent progress achieved in ultra-high dose rate radiobiology experiments employing laser-driven protons, including a brief discussion of the relevant methodology and dosimetry approaches.

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Section: Diagnostics and Dosimetrymentioning

confidence: 99%

Radiobiology Experiments With Ultra-high Dose Rate Laser-Driven Protons: Methodology and State-of-the-Art

Chaudhary¹,

Milluzzo

Ahmed

et al. 2021

Front. Phys.

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“…II B). The DOSION ionization chamber [21] used as the beam monitor can then be seen (see Sec. II D for more details) as well as the γ detection system along with the target propulsion arm.…”

Section: A General Considerationsmentioning

confidence: 99%

“…Table II gives the different beam energies obtained with the degraders as well as the percentage of charged particles created by nuclear interactions in the degraders and reaching the target. These percentages were evaluated by Monte Carlo simulations to be mostly protons and α particles (see [21] for further details).…”

Section: B Beam Energiesmentioning

confidence: 99%

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Cross section measurements for production of positron emitters for PET imaging in carbon therapy

et al. 2017

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International audienceIn light ion beam therapy, positron (β+) emitters are produced by the tissue nuclei through nuclear interactions with the beam ions. They can be used for the verification of the delivered dose using positron emission tomography by comparing the spatial distribution of the β+ emitters activity to a computer simulation taking into account the patient morphology and the treatment plan. However, the accuracy of the simulation greatly depends on the method used to generate the nuclear interactions producing these emitters. In the case of Monte Carlo (MC) simulations, the nuclear interaction models still lack the required accuracy due to insufficient experimental cross section data. This is particularly true for carbon therapy where literature data on fragmentation cross sections of a carbon beam with targets of medical interest are very scarce. Therefore, we performed at GANIL in July 2016 measurements on β+ emitter production cross sections with a carbon beam at 25, 50, and 95 MeV/nucleon on thin targets (C, N, O, and PMMA). We extracted the production cross section of C10,11, N13, and O14,15 that are essential to constrain or develop MC nuclear fragmentation models

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“…This is for instance the case for proton therapy systems based on quasicontinuous accelerators (like isochronous cyclotrons) and can be practically achieved by shrinking the electrode gap of the IC and/or increasing the applied high voltage. As an example, the ionisation chamber DOSION [146] has been modified to achieve ion recombination less than 1% for instantaneous dose-rates up to 1 kGy/s. It also includes different current dividers from 1/100 th to 1/10000 th to avoid electrometer saturation.…”

Section: Monitor Chambers For Flash Proton Beamsmentioning

confidence: 99%

The European Joint Research Project UHDpulse – Metrology for advanced radiotherapy using particle beams with ultra-high pulse dose rates

et al. 2020

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UHDpulse -Metrology for advanced radiotherapy using particle beams with ultra-high pulse dose rates is a recently started European Joint Research Project with the aim to develop and improve dosimetry standards for FLASH radiotherapy, very high energy electron (VHEE) radiotherapy and laser-driven medical accelerators. This paper gives a short overview about the current state of developments of radiotherapy with FLASH electrons and protons, very high energy electrons as well as laser-driven particles and the related challenges in dosimetry due to the ultra-high dose rate during the short radiation pulses. We summarize the objectives and plans of the UHDpulse project and present the 16 participating partners.

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Characterization and performances of DOSION, a dosimetry equipment dedicated to radiobiology experiments taking place at GANIL

Cited by 7 publications

References 9 publications

Radiobiology Experiments With Ultra-high Dose Rate Laser-Driven Protons: Methodology and State-of-the-Art

Radiobiology Experiments With Ultra-high Dose Rate Laser-Driven Protons: Methodology and State-of-the-Art

Cross section measurements for production of positron emitters for PET imaging in carbon therapy

The European Joint Research Project UHDpulse – Metrology for advanced radiotherapy using particle beams with ultra-high pulse dose rates

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