Characterization and phylogeny of bitter taste receptor genes (Tas2r) in Squamata

Zhong, Huaming; Shang, Shuai; Zhang, Huanxin; Wu, Xiaoyang; Zhang, Honghai

doi:10.1007/s10709-019-00056-4

Cited by 8 publications

(12 citation statements)

References 57 publications

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“…We collected the T2R protein sequences of western clawed frog, human, mouse and chicken from NCBI (Supplemental Table S17) and used them as reference sequences to identify the T2R sequences of other species. In total, 121 T2R genes were identified, and the number of T2Rs in these seven species was similar to recent studies (Li and Zhang 2014;Zhong et al 2019), but with some differences, which are controllable considering the differences in methods. The number of T2Rs expanded considerably in the insectivorous A. carolinensis and G. japonicus, and is significantly greater than in other species, and multiple independent duplications of the T2R in several species were clearly observed in the phylogenetic tree, dispersed among different clades (Fig.…”

Section: Bitter Taste Perception and Its Evolutionsupporting

confidence: 77%

“…It has long been shown that T2Rs, genes related to bitter taste perception, are widespread in vertebrates, varies widely among species and that lineage-specific gene duplication events have been detected in bony fishes, frogs, mammals and lizards (Dong et al 2009). A recent comprehensive analysis by Zhong et al (Zhong et al 2019) for T2Rs in squamates has demonstrated that T2Rs are extensively duplicated and expanded in several gecko and lizard lineages, and our location distribution and phylogenetic analyses suggest that this expansion is likely to result from tandem duplication in multiple species. We found that most of the branches under positive selection were located within clades related to G. japonicus and A. carolinensis, which is concordant with their extensive duplication and expansion, and all these results suggest that T2Rs are important for the adaptive evolution in G. japonicus, or insectivorous lizards and geckos.…”

Section: Discussionmentioning

confidence: 99%

“…The taste receptor type 2 (T2R) family, a subfamily of the taste receptor family with seven transmembrane segments, plays an significant role in bitter taste perception (Bachmanov and Beauchamp 2007). Its numerical size and gene repertoire composition vary considerably among vertebrates, as evidenced by recent detailed gene identification and phylogenetic studies of the squamates and verterbrates, and demonstrate a significant association between diet and the number of T2Rs (Li and Zhang 2014;Zhong et al 2019). We collected the T2R protein sequences of western clawed frog, human, mouse and chicken from NCBI (Supplemental Table S17) and used them as reference sequences to identify the T2R sequences of other species.…”

Section: Bitter Taste Perception and Its Evolutionmentioning

confidence: 99%

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Chromosome-level genome assembly provides insights into adaptive evolution of chromosome and important traits in the geckoGekko japonicus

Wang

Yue

et al. 2023

Preprint

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Gekko japonicus possess excellent flexible climbing and detoxification ability under insectivorous habits, and its chromosomes and the genetic evolutionary mechanisms behind these traits are still unclarified. Here, we assembled a chromosome-level genome of G. japonicus with a total size of 2.53 Gb contained in 19 pairs of chromosomes. The evolutionary breakpoint regions (EBRs) are significantly enriched for some repetitive elements compared to the rest of genome and the genes located in the EBRs are enriched in defense response pathway. G. japonicus specific gene families, expanded gene families and positively selected genes are mainly enriched in some pathways related to the immune, sensory and nervous systems. These results from comprehensive comparative genomics and evolutionary genomics analyses indicated that bitter taste receptor type 2 (T2Rs) expanded in different lineages by tandem gene duplication. The expansion and independent duplication events of T2Rs and positively selected branches were predominantly present in insectivorous species, suggests that T2Rs are associate with clearance of bitter toxins in gekkotans. Detoxification genes in detox and biosynthetic cytochrome P450 of G. japonicas have frequent duplication and loss events, suggests that they undergo more birth and death processes compared to biosynthesis type genes. Pro, Cys, Gly and Ser are the most abundant amino acids in 66 epidermis formation corneous beta proteins (CBPs) of G. japonicas, the abundance of Gly and Cys in CBPs implying significant effects on the flexibility and setae adhesiveness of gekkotans. Some thermosensitive thermoregulatory transient receptor potential channels under relaxed purifying selection or positive selection in G. japonicus, implying that one of the important factors improve the ability to adapt to climate change.

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Section: Bitter Taste Perception and Its Evolutionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Bitter Taste Perception and Its Evolutionmentioning

confidence: 99%

See 1 more Smart Citation

Chromosome-level genome assembly provides insights into adaptive evolution of chromosome and important traits in the geckoGekko japonicus

Wang

Yue

et al. 2023

Preprint

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“…Several studies have indicated that the repertoire of Tas2rs showed a very dynamic evolution among species. For instance, the number of intact (functional) Tas2rs is subject to intense variation: 0 in cetaceans and penguins (Feng et al, 2014 ; Zhu et al, 2014 ), 25 in humans (Go et al, 2005 ; Shi et al, 2003 ), 3–50 in lizards (Zhong et al, 2017 , 2019 ), 1–5 in teleost (Dong et al, 2018 ), and 80 in the coelacanth ( Latimeria chalumnae ; Syed & Korsching, 2014 ). Not surprisingly, there are varying numbers of pseudogenes among species.…”

Section: Introductionmentioning

confidence: 99%

Evolutionary insights into umami, sweet, and bitter taste receptors in amphibians

Zhong

Huang

Shang

et al. 2021

Ecology and Evolution

Self Cite

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taste sense is thought to have evolved to face a challenge or play a specific role in species evolution (Marco & Davide, 2017;Peng et al., 2020). For instance, sweet and umami tastes are associated with the intake of nutrients such as carbohydrates and protein.Conversely, bitter detection prevents animals from ingesting potentially poisonous foods (Herness & Gilbertson, 1999). Sweet, umami and bitter substances are detected by type II taste receptor cells (TRCs) that function through G protein-coupled receptors (GPCRs;Adler et al., 2000).

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“…At the molecular level, bitter taste is mediated by means of taste 2 receptors (Tas2rs). Studies on Tas2r have made the main advances in the latest years [13]. Human TAS2R genes are positioned on chromosomes 7 are rather polymorphic.…”

Section: Genes Related To the Bitter Tastementioning

confidence: 99%

The roles of genes in the bitter taste

Smail

2019

AIMS Genetics

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The aims of this review were to understand the roles of bitter taste genes in humans. Some of the peoples have the capacity to taste some chemical substance such as phenylthiocarbamide (PTC) while others cant not based on the dietary hazards and food preferences. There are two alleles responsible to express these phenotypes which are homozygous recessive. In human TAS2R38 genes located on the chromosome number 7 and consist of different nucleotide polymorphism that related to detection of the phenotype of different chemical compounds such as 6-n-propylthiouracil (PROP) and phenylthiocarbamide bitterness and this Gene is the member of the TAS2R genes which are eleven pseudogenes and twenty that has roles in many biological processes. There are many factors that affect the bitter taste such as food, age, sex, and different diseases. The mechanism of food bitter taste and genotype of TAS2R38 until know not well understood due to that the proof of relation between bitter taste sensitivity and food is harmful. there are many different diseases can impact the influence of taste such as neoplasm and lifestyle such as consumption of alcohol along with the use of medication, head trauma, upper tract infections. On the other hand, A relation between TAS2R38 genotype and meal preferences has been observed among children, however, no associations have been mentioned among older adults. Some previous research proved some vital points that show an association between type 1 of diabetes and phenylthiocarbamide (PTC) but other studies cannot demonstrate that. However, of other disease such as obesity is controversial but other studies reported to the relationship between them.

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Characterization and phylogeny of bitter taste receptor genes (Tas2r) in Squamata

Cited by 8 publications

References 57 publications

Chromosome-level genome assembly provides insights into adaptive evolution of chromosome and important traits in the geckoGekko japonicus

Chromosome-level genome assembly provides insights into adaptive evolution of chromosome and important traits in the geckoGekko japonicus

Evolutionary insights into umami, sweet, and bitter taste receptors in amphibians

The roles of genes in the bitter taste

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