Characterization and potential applications of nanostructured aqueous dispersions

Yaghmur, Anan; Glatter, Otto

doi:10.1016/j.cis.2008.07.007

Cited by 350 publications

(300 citation statements)

References 106 publications

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“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] The investigations, by means of time-resolved SAXS, of the dynamic topological transitions of selfassembled amphiphilic mixtures have allowed the discovery of lipid-based nanocarriers with tunable internal organizations and nanochannel sizes. [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] The phase states of nonlamellar lipids, amphiphilic mixtures with lipopolymers or lipophilic conjugates, such as peptide surfactants, squalenoyl (SQ) derivatives, and acylated and peptidolipidyl-modified cyclodextrins, have been studied toward the design of novel controlled drug delivery nanocarriers with enhanced performance. In this Account, we discuss structural studies of lipid and lipid-polymer self-assemblies in aqueous phase that characterized the nanochannel network organization of amphiphilic vehicles for entrapment of proteins and peptides, as well as of DNA.…”

Section: Introductionmentioning

confidence: 99%

Self-Assembled Multicompartment Liquid Crystalline Lipid Carriers for Protein, Peptide, and Nucleic Acid Drug Delivery

et al. 2010

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L ipids and lipopolymers self-assembled into biocompatible nanoand mesostructured functional materials offer many potential applications in medicine and diagnostics. In this Account, we demonstrate how high-resolution structural investigations of bicontinuous cubic templates made from lyotropic thermosensitive liquid-crystalline (LC) materials have initiated the development of innovative lipidopolymeric self-assembled nanocarriers. Such structures have tunable nanochannel sizes, morphologies, and hierarchical inner organizations and provide potential vehicles for the predictable loading and release of therapeutic proteins, peptides, or nucleic acids. This Account shows that structural studies of swelling of bicontinuous cubic lipid/water phases are essential for overcoming the nanoscale constraints for encapsulation of large therapeutic molecules in multicompartment lipid carriers.For the systems described here, we have employed time-resolved small-angle X-ray scattering (SAXS) and high-resolution freeze-fracture electronic microscopy (FF-EM) to study the morphology and the dynamic topological transitions of these nanostructured multicomponent amphiphilic assemblies. Quasi-elastic light scattering and circular dichroism spectroscopy can provide additional information at the nanoscale about the behavior of lipid/protein self-assemblies under conditions that approximate physiological hydration.We wanted to generalize these findings to control the stability and the hydration of the water nanochannels in liquidcrystalline lipid nanovehicles and confine therapeutic biomolecules within these structures. Therefore we analyzed the influence of amphiphilic and soluble additives (e.g. poly(ethylene glycol)monooleate (MO-PEG), octyl glucoside (OG), proteins) on the nanochannels' size in a diamond (D)-type bicontinuous cubic phase of the lipid glycerol monooleate (MO). At body temperature, we can stabilize long-living swollen states, corresponding to a diamond cubic phase with large water channels. Time-resolved X-ray diffraction (XRD) scans allowed us to detect metastable intermediate and coexisting structures and monitor the temperature-induced phase sequences of mixed systems containing glycerol monooleate, a soluble protein macromolecule, and an interfacial curvature modulating agent. These observed states correspond to the stages of the growth of the nanofluidic channel network.With the application of a thermal stimulus, the system becomes progressively more ordered into a double-diamond cubic lattice formed by a bicontinuous lipid membrane. High-resolution freeze-fracture electronic microscopy indicates that nanodomains are induced by the inclusion of proteins into nanopockets of the supramolecular cubosomic assemblies. These results contribute to the understanding of the structure and dynamics of functionalized self-assembled lipid nanosystems during stimuli-triggered LC phase transformations.

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Section: Introductionmentioning

confidence: 99%

Self-Assembled Multicompartment Liquid Crystalline Lipid Carriers for Protein, Peptide, and Nucleic Acid Drug Delivery

et al. 2010

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“…When these LCs are dispersed into nanoparticles by the addition of excess water with stabilizers such as Pluronic copolymers and Myrj series 23,24 , they form stable colloidal dispersions that are termed cubosomes and hexosomes, respectively 25,26 . Cubic bicontinuous phases have been identified, based on their surfaces: primitive Im3m , diamond Pn3m , and, most frequently, gyroid Ia3d bicontinuous LC phases.…”

Section: Introductionmentioning

confidence: 99%

A Novel Chemical Enhancer Approach for Transdermal Drug Delivery with C<sub>17</sub>-Monoglycerol Ester Liquid Crystal-forming Lipid

et al. 2017

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“…15 Finally, the cubic phases can enhance the stability of drugs and reduce drug stimulation on the GIT. 16 Most studies have focused on glyceryl monooleate (GMO) as a liquid crystal-forming lipid, but glyceride lipids possess ester bonds that are susceptible to degradation by lipase enzymes in the GIT. This phenomenon was previously observed with GMO cubosomes in in vitro digestion models, 17 implying a loss of liquid crystal structure in vivo.…”

Section: Introductionmentioning

confidence: 99%

Cubic phase nanoparticles for sustained release of ibuprofen formulation characterization and enhanced bioavailability study

Dian¹,

Yang²,

Li³

et al. 2013

IJN

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Abstract:In order to improve the oral bioavailability of ibuprofen, ibuprofen-loaded cubic nanoparticles were prepared as a delivery system for aqueous formulations. The cubic inner structure was verified by cryogenic transmission electron microscopy. With an encapsulation efficiency greater than 85%, the ibuprofen-loaded cubic nanoparticles had a narrow size distribution around a mean size of 238 nm. Differential scanning calorimetry and X-ray diffraction determined that ibuprofen was in an amorphous and molecular form within the lipid matrix. The in vitro release of ibuprofen from cubic nanoparticles was greater than 80% at 24 hours, showing sustained characteristics. The pharmacokinetic study in beagle dogs showed improved absorption of ibuprofen from cubic nanoparticles compared to that of pure ibuprofen, with evidence of a longer half-life and a relative oral bioavailability of 222% (P , 0.05). The ibuprofen-loaded cubic nanoparticles provide a promising carrier candidate with an efficient drug delivery for therapeutic treatment.

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Characterization and potential applications of nanostructured aqueous dispersions

Cited by 350 publications

References 106 publications

Self-Assembled Multicompartment Liquid Crystalline Lipid Carriers for Protein, Peptide, and Nucleic Acid Drug Delivery

Self-Assembled Multicompartment Liquid Crystalline Lipid Carriers for Protein, Peptide, and Nucleic Acid Drug Delivery

A Novel Chemical Enhancer Approach for Transdermal Drug Delivery with C<sub>17</sub>-Monoglycerol Ester Liquid Crystal-forming Lipid

Cubic phase nanoparticles for sustained release of ibuprofen formulation characterization and enhanced bioavailability study

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