Characterization and proteomics of chicken seminal plasma extracellular vesicles

Luo, Xuliang; Guo, Yan; Huang, Ying; Cheng, Manman; Wu, Xiaohui; Gong, Yanzhang

doi:10.1111/rda.14033

Cited by 11 publications

(7 citation statements)

References 63 publications

(59 reference statements)

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“…While extracellular vesicles (EVs) have been extensively characterised in mammals, studies elucidating EVs in avian species remain scarce. Recent proteomic analysis ( Luo et al, 2022 ) of EVs from rooster seminal plasma identified over 3,000 proteins, including many involved in sperm maturation and antimicrobial protection. This suggests avian EVs may regulate fertility, akin to prostasomes in mammals ( Muñoz et al, 2022 ).…”

Section: Evs In Non-mammalian Vertebratesmentioning

confidence: 99%

Bridging the extracellular vesicle knowledge gap: insights from non-mammalian vertebrates, invertebrates, and early-diverging metazoans

Liegertová,

Janoušková

2023

Front. Cell Dev. Biol.

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Extracellular vesicles (EVs) are lipid-enclosed structures that facilitate intercellular communication by transferring cargo between cells. Although predominantly studied in mammals, extracellular vesicles are ubiquitous across metazoans, and thus research in non-mammalian models is critical for fully elucidating extracellular vesicles biology. Recent advances demonstrate that extracellular vesicles mediate diverse physiological processes in non-mammalian vertebrates, including fish, amphibians, and reptiles. Piscine extracellular vesicles promote fin regeneration in zebrafish and carry heat shock proteins regulated by stress. Frog extracellular vesicles containing microRNAs modulate angiogenesis, while turtle extracellular vesicles coordinate reproductive functions. Venom from snakes contains extracellular vesicles that mirror the whole venom composition and interact with mammalian cells. Invertebrates also possess extracellular vesicles involved in immunity, development, and pathogenesis. Molluscan extracellular vesicles participate in shell formation and host interactions. Arthropod models, including Drosophila, genetically dissect conserved pathways controlling extracellular vesicles biogenesis and signalling. Nematode extracellular vesicles regulate larval development, animal communication, and ageing via conserved extracellular vesicles proteins. Ancient metazoan lineages utilise extracellular vesicles as well, with cnidarian extracellular vesicles regulating immunity and regeneration. Ultimately, expanding extracellular vesicles research beyond typical biomedical models to encompass phylogenetic diversity provides an unparalleled perspective on the conserved versus specialised aspects of metazoan extracellular vesicles roles over ∼500 million years. With a primary focus on the literature from the past 5 years, this review aims to reveal fundamental insights into EV-mediated intercellular communication mechanisms shaping animal physiology.

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Section: Evs In Non-mammalian Vertebratesmentioning

confidence: 99%

Bridging the extracellular vesicle knowledge gap: insights from non-mammalian vertebrates, invertebrates, and early-diverging metazoans

Liegertová,

Janoušková

2023

Front. Cell Dev. Biol.

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“…In animals, seminal fluid carries various kinds of extracellular vesicles (e.g., micro- and nanovesicles, exosomes, proteasomes, etc.) containing Sfcs [ 87 , 88 , 89 , 90 , 91 , 92 , 93 ], and this cargo has many essential functions in sperm fertilization success [ 89 , 90 , 93 , 94 , 95 , 96 , 97 , 98 , 99 ]. The extracellular vesicles of seminal fluid can be transferred between cells and tissues and deliver the contents to a target cell/tissue [ 100 , 101 , 102 , 103 ].…”

Section: The Potential Mechanisms Of Seminal Fluid-mediated Paternal ...mentioning

confidence: 99%

On the Role of Seminal Fluid Protein and Nucleic Acid Content in Paternal Epigenetic Inheritance

Patlar

2022

IJMS

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The evidence in this study supports the occurrence of environmentally-induced paternal epigenetic inheritance that shapes the offspring phenotype in the absence of direct or indirect paternal care and clearly demonstrates that sperm epigenetics is one of the major actors mediating these paternal effects. However, in most animals, while sperm makes up only a small portion of the seminal fluid, males also have a complex mixture of proteins, peptides, different types of small noncoding RNAs, and cell-free DNA fragments in their ejaculate. These seminal fluid contents (Sfcs) are in close contact with the reproductive cells, tissues, organs, and other molecules of both males and females during reproduction. Moreover, their production and use are adjusted in response to environmental conditions, making them potential markers of environmentally- and developmentally-induced paternal effects on the next generation(s). Although there is some intriguing evidence for Sfc-mediated paternal effects, the underlying molecular mechanisms remain poorly defined. In this review, the current evidence regarding the links between seminal fluid and environmental paternal effects and the potential pathways and mechanisms that seminal fluid may follow in mediating paternal epigenetic inheritance are discussed.

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“…In animals, seminal fluid carries various kinds of extracellular vesicles (e.g., micro-and nano-vesicles, exosomes, etc.) that contain different molecules including proteins, peptides, mRNAs, and sRNAs [85][86][87][88][89][90][91], and this cargo has many essential functions for sperm fertilization success [87,88,[91][92][93][94][95][96][97]. These extracellular vesicles of seminal fluid can be transferred between cells and tissues, and release their content to a targeted cell [98][99][100][101].…”

Section: Seminal Fluid Mediates Sperm Epigeneticsmentioning

confidence: 99%

On the Role of Seminal Fluid Protein and Nucleic Acid Content in the Paternal Epigenetic Inheritance

Patlar¹

2022

Preprint

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The evidence supports the occurrence of environmentally induced paternal epigenetic inheritance shaping the offspring phenotype in the absence of direct or indirect paternal care, and the empirical results clearly indicate that sperm epigenetics is one of the major actors mediating these paternal effects. However, sperm often make up only a small fraction of the male ejaculate in animals. Males also have a complex mixture of proteins, peptides, types of small RNAs, and cell-free DNA fragments in their seminal fluid. These molecules are in close contact with reproductive cells, tissues, organs, and other molecules of both males and females during reproduction. Moreover, their production and use are very sensitive to environmental conditions which makes them potential modulators of environmentally and developmentally induced paternal effects on the next generation(s). Although there is some intriguing evidence of seminal fluid-mediated paternal epigenetic effects, the underlying molecular mechanisms remain poorly defined. In this review, I discuss the current evidence regarding the association between seminal fluid and environmentally induced paternal effects, the possible trajectories, and the mechanisms in which seminal fluid can involve to mediate paternal epigenetic inheritance.

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Characterization and proteomics of chicken seminal plasma extracellular vesicles

Cited by 11 publications

References 63 publications

Bridging the extracellular vesicle knowledge gap: insights from non-mammalian vertebrates, invertebrates, and early-diverging metazoans

Bridging the extracellular vesicle knowledge gap: insights from non-mammalian vertebrates, invertebrates, and early-diverging metazoans

On the Role of Seminal Fluid Protein and Nucleic Acid Content in Paternal Epigenetic Inheritance

On the Role of Seminal Fluid Protein and Nucleic Acid Content in the Paternal Epigenetic Inheritance

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