2011
DOI: 10.1002/jps.22484
|View full text |Cite
|
Sign up to set email alerts
|

Characterization and Quantification of Amorphous Material in Milled and Spray-Dried Salbutamol Sulfate: A Comparison of Thermal, Spectroscopic, and Water Vapor Sorption Approaches

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

2
17
0

Year Published

2011
2011
2018
2018

Publication Types

Select...
3
3
1

Relationship

0
7

Authors

Journals

citations
Cited by 40 publications
(22 citation statements)
references
References 40 publications
2
17
0
Order By: Relevance
“…In general it is not clear if polymorphic transformations are direct crystal-crystal transformations or if an intermediate stage of transient amorphization or a transient unstable crystal phase is generated which is followed by a rapid recrystallization process to a known polymorph [27]. Several theories have been proposed to describe the mechanism of amorphization upon milling [5,27,[30][31][32]. One widespread hypothesis suggests that amorphization is the result of local thermal melting that is followed by a rapid quench [30].…”
Section: The Effect Of Neat Milling On Forms I To Vmentioning
confidence: 99%
See 1 more Smart Citation
“…In general it is not clear if polymorphic transformations are direct crystal-crystal transformations or if an intermediate stage of transient amorphization or a transient unstable crystal phase is generated which is followed by a rapid recrystallization process to a known polymorph [27]. Several theories have been proposed to describe the mechanism of amorphization upon milling [5,27,[30][31][32]. One widespread hypothesis suggests that amorphization is the result of local thermal melting that is followed by a rapid quench [30].…”
Section: The Effect Of Neat Milling On Forms I To Vmentioning
confidence: 99%
“…Another suggestion is that amorphization results from a lattice instability induced by a progressive static disordering of the initial crystals [4,27]. In addition, Fecht [31,32] has further suggested that the mechanism is associated with the accumulation of lattice defects in the crystal resulting in an increase in the entropy of the crystal until it is above that of the liquid and if the temperature is below the glass transition temperature (Tg) the system effectively enters an amorphous state as if it were melting below the melting point. In this study no evidence for an unstable intermediate crystal form was found and transition through an amorphous form seems to be the most likely.…”
Section: The Effect Of Neat Milling On Forms I To Vmentioning
confidence: 99%
“…Some inconsistencies of SEM, PXRD and IR results were observed. These are likely to be caused by the effect of sampling on the results obtained by different characterisation methods (Grisedale et al, 2011). Nevertheless from the data, two general observations can be summarized.…”
Section: Discussionmentioning
confidence: 93%
“…In mDSC analysis, the positive overall periodic minimum heating rate ensures proper deconvolution of crystallization exotherm. Grisedale et al (2010) studied crystallization kinetics of amorphous salbutamol sulfate using mDSC and found that the spray-dried product had the higher T C and E C compared to that of the milled ones and for the latter these values increased with milling time.…”
Section: Crystallization Melting Crystallinity and Mixing Interactmentioning
confidence: 98%
“…These two events occurring at different temperature need correction for the temperature-dependent enthalpy. Equation 14.6 determines the initial crystallinity including the correction for the possible noncrystallizing fraction (α NC ; Grisedale et al 2010):…”
Section: Crystallization Melting Crystallinity and Mixing Interactmentioning
confidence: 99%